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Product Name: Etilefrine Hydrochloride
Chemical Formula: C10H15NO3·HCl
CAS Number: 429-97-4
Synonyms: (RS)-ethyl[3-(1-hydroxy-2-(methylamino)ethyl)phenyl]acetate hydrochloride
Recommended Use: Used as a pharmaceutical agent for hypotension
Supplier Details: Pharmaceutical manufacturers, lab supply companies
Emergency Phone Number: Available from local health and poison control centers
GHS Classification: Harmful if swallowed. May cause eye, skin, and respiratory irritation. Hazardous in case of eye or skin contact, ingestion, or inhalation.
Signal Word: Warning
Hazard Statements: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)
Precautionary Statements: Avoid breathing dust or fumes. Use protective equipment. Wash hands thoroughly after handling. Do not eat, drink, or smoke during use.
Symptoms of Overexposure: Headache, nausea, increased heart rate, dizziness, excessive sweating, agitation, palpitations, hypertension
Chemical Name: Etilefrine Hydrochloride
EC Number: 207-097-0
Purity: 98% and above (pharmaceutical grade)
Impurities: Less than 1%, mainly related organic compounds
Mixture: Single substance
Inhalation: Move person to fresh air. Provide oxygen if breathing is difficult. Get medical attention.
Skin Contact: Remove contaminated clothing. Wash affected area with soap and water. Seek medical advice if irritation develops.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Medical attention recommended.
Ingestion: Rinse mouth. Seek immediate medical attention. Do not induce vomiting unless directed by medical personnel.
Most Important Symptoms and Effects: Excessive stimulation of the heart, sweating, restlessness, and potential nervous system effects
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide.
Specific Hazards: May emit toxic fumes under fire conditions including nitrogen oxides, hydrogen chloride, and carbon monoxide.
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear.
Fire Fighting Instructions: Evacuate area, avoid inhalation of smoke, keep containers cool with water spray, prevent run-off.
Personal Precautions: Use respiratory and skin protection. Ventilate area. Remove sources of ignition.
Environmental Precautions: Prevent material from entering drains, surface and groundwater. Notify authorities if large spill occurs.
Cleaning Methods: Collect residual material with inert absorbent (sand, diatomaceous earth). Dispose in tightly sealed containers. Wash area thoroughly with water.
Handling: Use appropriate PPE including gloves, lab coat, safety goggles, and mask. Avoid creating dust. Handle only in areas with adequate ventilation. Practice good hygiene.
Storage: Store in tightly closed container at room temperature in dry, cool, and well-ventilated place away from heat, moisture, and incompatible substances (acids, oxidizers).
Incompatible Materials: Strong acids, strong bases, strong oxidizers. Separate from food and feed.
Exposure Limits: No occupational exposure limits established for etilefrine hydrochloride.
Engineering Controls: Work in fume hood or with local exhaust. Use safety showers and eyewash stations.
Personal Protection: Safety goggles, chemical-resistant gloves, lab coat, adequate respiratory protection if dust forms.
General Hygiene: Do not eat, drink, or smoke during use. Wash hands before breaks and at end of work.
Appearance: White or almost white crystalline powder
Odor: Odorless or slight characteristic odor
Melting Point: 150°C – 160°C
Solubility: Soluble in water, slightly soluble in ethanol, practically insoluble in ether
pH (1% Solution): 4.5–6.0
Boiling Point: Data not available (decomposes before boiling)
Vapor Pressure: Not expected to be significant at room temperature
Density: Approximately 1.2 g/cm³
Flash Point: Not applicable
Partition Coefficient (log Kow): Not determined
Chemical Stability: Stable under recommended storage conditions and normal temperatures.
Reactivity: Not especially reactive. Avoid contact with strong oxidizing agents and acids.
Hazardous Reactions: May produce toxic gases if heated to decomposition.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride gas.
Routes of Exposure: Inhalation, ingestion, eye, and skin contact
Acute Toxicity: Oral LD50 (rat): 270 mg/kg (estimate)
Potential Health Effects: Rapid pulse, high blood pressure, tremors, sweating, headaches, nervousness, restlessness, possible arrhythmias
Chronic Effects: No long-term toxicity data available in humans
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity: Data is limited; no significant evidence of genetic mutagenicity documented
Other Information: Prescription medication, avoid uncontrolled exposure
Ecotoxicity: Limited data indicate low toxicity to aquatic life (based on structural characteristics).
Persistence and Degradability: Expected to degrade via biological action under environmental conditions, but data is not extensive.
Bioaccumulative Potential: Low potential for bioaccumulation appears likely due to water solubility.
Mobility in Soil: High mobility expected in soil based on water solubility.
Other Adverse Effects: Avoid release to waterways, as pharmaceutical residues can disrupt aquatic ecosystems.
Waste Disposal Methods: Follow local, regional, and national regulations for disposal of pharmaceutical substances. Incineration in a chemical incinerator with afterburner and scrubber recommended.
Contaminated Packaging: Dispose of as unused product. Containers should be triple rinsed and offered for recycling or disposal via specialized waste contractor.
Precautions: Do not dispose of with household waste or into the environment.
UN Number: Not assigned for transport; handle as non-hazardous for transport under most jurisdictions.
Transport Hazard Class: Not classified as hazardous for transport.
Packing Group: Not assigned
Environmental Hazards: None identified, but avoid bulk accidental release.
Special Precautions: Handle with standard laboratory and pharmaceutical safety procedures during movement.
OSHA Status: Not classified as hazardous under OSHA Hazard Communication Standard.
TSCA Status: Not listed.
WHMIS Classification: Not controlled under WHMIS.
EU Regulations: Not classified under EU CLP Regulation for typical use as a pharmaceutical agent; prescription drug status applies.
Inventory Listings: May not appear on major chemical inventories; subject to pharmaceutical regulations.
Other Regulatory Information: Prescription use only under supervision of licensed practitioner. National poison control and workplace safety standards apply.
