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Product Name: Methyl N-Butyrate
Chemical Formula: C5H10O2
CAS Number: 623-42-7
Synonyms: Methyl butanoate, Butyric acid methyl ester
Recommended Use: Industrial solvent, chemical intermediate, flavor and fragrance applications
Manufacturer’s Details: Name and address available on request from local supplier
Emergency Contact Number: National Poison Control Center or local emergency response
GHS Classification: Flammable Liquid (Category 3), Eye Irritant (Category 2A), Acute Toxicity Oral (Category 5)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. May cause eye irritation. May be harmful if swallowed.
Pictograms: Flame, Exclamation Mark
Precautionary Statements: Keep away from heat/sparks/open flames/hot surfaces. Wear protective gloves and eye protection. Avoid breathing vapors.
Chemical Name: Methyl N-Butyrate
Concentration: ≥99%
Impurities: Trace water, residual acids, trace alcohols
Molecular Weight: 102.13 g/mol
Other Ingredients: No significant hazardous impurities present above concentration limits
Inhalation: Move person to fresh air, keep comfortable, get medical help if symptoms persist. Remove contaminated clothing.
Skin Contact: Rinse skin thoroughly with water for at least 15 minutes. Remove contaminated clothing and wash before reuse.
Eye Contact: Flush eyes gently with water for several minutes, hold eyelids apart, remove contact lenses if present and easy. Seek medical advice if irritation continues.
Ingestion: Rinse mouth with water. Do not induce vomiting. Get medical attention if you feel unwell.
Most Important Symptoms/Effects: May cause burning sensation in eyes, mild respiratory or gastrointestinal irritation.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam. Water spray can cool containers but may not disperse vapor clouds effectively.
Specific Hazards: Vapor forms explosive mixtures with air. Containers exposed to heat may burst. Combustion produces carbon monoxide, carbon dioxide, irritating fumes.
Special Protective Equipment: Use self-contained breathing apparatus and full protective gear. Stay upwind, keep fire-exposed containers cool, and evacuate area if large spills or fire.
Personal Precautions: Evacuate personnel from the affected area. Keep sources of ignition away. Provide ventilation.
Environmental Precautions: Prevent chemical from entering drains, sewers, or water bodies. Alert authorities if there is significant contamination.
Spill Cleanup Methods: Absorb spill with inert material like sand, soil, or commercial absorbent. Scoop residue into suitable chemical waste container. Clean area with plenty of water.
Handling: Use only with adequate ventilation or fume extraction. Avoid breathing vapor or mist. Do not handle near ignition sources, heated surfaces, or in confined spaces without safeguards.
Storage: Store in tightly closed approved containers. Keep in a dry, cool, well-ventilated place with ground-level storage preferred. Segregate from oxidizing agents, acids, and foodstuffs. Protect containers from physical damage.
Occupational Exposure Limits: No official limit established, but observe general nuisance limits; typical threshold limit value (TLV) not available; reduce exposure to lowest feasible
Engineering Controls: Ensure sufficient ventilation, local exhaust at points of emission. Use explosion-proof electrical fixtures.
Personal Protective Equipment: Wear splash goggles or face shield, chemical-resistant gloves (like nitrile or neoprene), protective clothing as needed. If vapor or mist is generated, use respiratory protection approved for organic vapors.
Hygiene Practices: Wash hands thoroughly after handling and before eating or drinking. Remove soiled clothing and clean before reuse.
Appearance: Colorless liquid
Odor: Fruity, pleasant
Melting Point: -85 °C
Boiling Point: 102–104 °C
Flash Point: 19 °C (closed cup)
Vapor Pressure: 28 mm Hg at 25 °C
Solubility: Slightly soluble in water, miscible with alcohol and ether
Specific Gravity: 0.88 at 20 °C
Auto-ignition Temperature: 464 °C
Explosive Limits: 1.7% to 7.7% (by volume in air)
Chemical Stability: Stable under recommended storage conditions.
Conditions to Avoid: Heat, open flames, static discharge, ignition sources, prolonged exposure to air.
Incompatible Materials: Strong acids, strong bases, oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possible volatile organic compounds.
Polymerization: Does not occur under normal conditions.
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity: LD50 (oral, rat): ~ 4,000 mg/kg; LD50 (dermal, rabbit): >5,000 mg/kg. High vapor may cause mild central nervous system depression including dizziness and nausea.
Chronic Effects: Repeated or prolonged skin contact may cause dermatitis. No sufficient evidence for reproductive toxicity or carcinogenicity.
Symptoms: Eye or skin irritation, headache, dizziness; larger doses via ingestion may cause gastrointestinal discomfort or mild narcosis.
Sensitization: Not expected to cause sensitization.
Environmental Fate: Readily biodegradable. Volatilizes rapidly from water and soil.
Aquatic Toxicity: LC50 (fish, 96h): ~ 120 mg/L; EC50 (daphnia, 48h): ~ 230 mg/L. Low to moderate toxicity to aquatic organisms.
Persistence and Degradability: Substance expected to degrade in environment over days to weeks.
Bioaccumulation: Does not significantly bioaccumulate.
Other Adverse Effects: Large releases may lead to oxygen depletion and harm aquatic life.
Waste Disposal Methods: Dispose in accordance with local, regional, and national regulations regarding chemical waste.
Product Disposal: Incinerate under controlled conditions if available. Do not dump into sewers, on the ground, or into water bodies.
Container Disposal: Rinse with suitable solvent, puncture and send for recycling or disposal at approved facility.
Precautions: Wear suitable protection during disposal procedures, prevent inhalation or contact with skin.
UN Number: 1239
UN Proper Shipping Name: Methyl n-butyrate
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Marine Pollutant: No
Special Precautions for Transport: Package tightly, keep away from sparks, handle with care during loading and unloading, follow applicable hazardous material regulations.
Safety, Health, and Environmental Regulations: Component listed in TSCA (Toxic Substances Control Act), EINECS/ELINCS, and other major inventories.
OSHA: Not regulated as a specific hazardous material, but good management practices advised.
SARA Title III: Not listed under Section 302, 304, or 313.
REACH Status: Substance registered, proper use should follow SDS recommendations.
Labeling Requirements: Use GHS-compliant hazard and precaution labeling.
Worker Protection: Employers expected to train personnel about handling, risks, and personal protective measures.
International Use: Follow international carriage guidelines for dangerous goods under IATA, IMDG, ADR as applicable.
