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Product Name: Ethyl Diazoacetate
Synonyms: EDA, Ethyl diazoethanoate, Diazoacetic acid ethyl ester
Chemical Formula: C4H6N2O2
CAS Number: 623-73-4
Recommended Use: Laboratory chemical, used in organic synthesis, pharmaceutical research
Supplier: Chemical suppliers, laboratory distributors
Emergency Phone: Local emergency services, supplier emergency response numbers
GHS Classification: Explosive (Unstable), Acute Toxicity (Oral and Inhalation: Category 3), Skin Irritation (Category 2), Eye Irritation (Category 2A)
GHS Label Elements: Danger—explosion, toxic, irritant pictograms
Hazard Statements: Unstable explosive, toxic if swallowed or inhaled, causes skin and serious eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid all sources of ignition, keep away from heat, wear protective gear, use only with adequate ventilation, avoid breathing dust, fumes, mist, or vapors
Chemical Identity: Ethyl diazoacetate
Concentration: >98% (for reagent grade)
Impurities: Traces of acetic acid, ethanol possible (<2%)
Molecular Weight: 114.10 g/mol
Inhalation: Move the person to fresh air, keep at rest, provide oxygen if breathing is difficult, seek medical attention immediately
Skin Contact: Remove contaminated clothing, rinse skin quickly and thoroughly with water for at least 15 minutes, seek medical attention if redness or irritation develops
Eye Contact: Rinse continuously with water for several minutes, hold eyelids apart, consult a doctor immediately
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide, avoid strong water jets
Hazards from Combustion: Produces toxic fumes, including nitrogen oxides, carbon monoxide, carbon dioxide, possible explosions if confined
Protective Equipment: Self-contained breathing apparatus, full protective gear, evacuate area, stay upwind, use explosion-proof equipment
Personal Precautions: Evacuate personnel, ventilate area, wear chemical-resistant gloves, goggles, lab coat, avoid breathing mist or vapors
Environmental Precautions: Prevent entry into drains, water courses, soil
Clean-Up Methods: Absorb with inert material (vermiculite, sand), place in explosion-proof container, decontaminate area with dilute sodium thiosulfate solution, dispose of as hazardous waste
Safe Handling: Handle away from ignition sources and incompatible materials, ground all containers, avoid friction, don’t allow to dry or concentrate
Storage Conditions: Store in tightly closed original containers in cool, well-ventilated, explosion-proof area, segregate from acids, bases, oxidizing, and reducing agents, refrigerate below 4°C, protect from direct sunlight, monitor for pressure build-up
Incompatible Materials: Strong acids, strong bases, reducing agents, oxidizers, heat, direct sunlight
Engineering Controls: Work in chemical fume hood with non-sparking tools, use explosion-proof electrical and ventilation systems
Personal Protection: Wear nitrile gloves, chemical splash goggles, flame-retardant lab coat, appropriate respirator for volatile vapors
Exposure Limit Values: No official threshold limits known, minimize exposure as much as possible
Hygiene Measures: Wash hands thoroughly after handling, remove soiled clothing, prohibit eating or drinking in the work area
Appearance: Yellow to orange oily liquid
Odor: Faint, sweet or ether-like
Boiling Point: 80–82°C at 20 mmHg
Melting Point: Not applicable (liquid at room temp)
Flash Point: Decomposes
Vapor Pressure: 2 mmHg at 20°C
Density: 1.16 g/cm³ at 20°C
Solubility: Slightly soluble in water, soluble in alcohol, ether, chloroform
pH: Not available;
Partition Coefficient (n-octanol/water): Not available
Chemical Stability: Unstable, sensitive to shock, heat, and light
Hazardous Reactions: Explosive decomposition possible, especially under heating or when subjected to pressure
Incompatible Materials: Avoid contact with acids, bases, oxidizers, reducing agents
Decomposition Products: Nitrogen gas, carbon dioxide, carbon monoxide, irritating and toxic fumes
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Health Hazards: Highly toxic by ingestion and inhalation, severe eye and skin irritant
Acute Effects: Headache, dizziness, nausea, unconsciousness, burns to eyes or skin
Chronic Effects: No definitive long-term data for chronic toxicity; repeated exposure may damage organs
LD50 (oral, rat): Estimated 40–50 mg/kg
Carcinogenicity: Not classified as a known carcinogen
Mutagenicity/Teratogenicity: Data insufficient for classification
Toxicity to Aquatic Life: Likely toxic, avoid environmental release, limited data for specific aquatic toxicity
Persistence and Degradability: Expected to degrade slowly, breaks down to nitrogen-containing compounds
Bioaccumulation Potential: Low; not expected to bioaccumulate significantly
Other Adverse Effects: Risk of oxygen depletion in water due to nitrogen gas release, not classified as a major environmental hazard, but accidental spills can cause acute local effects
Disposal Methods: Treat as hazardous chemical waste, use licensed chemical waste contractor, consult local and national regulations
Container Disposal: Triple rinse, destroy container; do not reuse, label clearly
Decontamination: Avoid drains, neutralize with sodium thiosulfate or other recommended agent, dispose of residues by incineration in specialized facility
UN Number: UN 3357
Proper Shipping Name: Diazo compounds, explosive, n.o.s. (Ethyl diazoacetate)
Transport Hazard Class: 3 (Flammable liquid), 1.1 (Explosive, if not stabilized)
Packing Group: I (Highest danger)
Label Required: Explosive, toxic, flammable liquid
Special Precautions: Transport only in temperature-controlled, shock-resistant containers, notify authorities of movement, emergency response required during accidental release or fire events
Global Inventories: Not widely listed on chemical inventories; subject to special restrictions in many countries
Workplace Classification: Recognized as hazardous, explosive, and toxic
Regulatory Status: OSHA hazardous chemical, requires written hazard communication program
Labeling Requirements: Complies with GHS, OSHA, UN transport
Restrictions: Procurement and use often restricted to licensed laboratories with trained personnel
Other Regulations: Comply with all applicable national and international laws regarding explosives, toxic chemical handling, and storage
