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Product Name: Ethambutol Hydrochloride
Synonyms: Myambutol, EMB
Chemical Formula: C10H24N2O2∙2HCl
CAS Number: 1070-11-7
Intended Use: Pharmaceutical raw material, tuberculosis medication
Company Name: Major pharmaceutical manufacturers and laboratory suppliers
Contact (Emergency): Local Poison Control Center, company emergency numbers, national emergency contact
Classification: Eye irritation, specific organ toxicity, irritation to skin and mucous membranes
Routes of Exposure: Inhalation, ingestion, dermal contact, eye contact
Health Hazards: May cause blindness over long exposure, particularly optic neuritis, gastrointestinal upset, allergic skin reaction
Physical Hazards: Dust may irritate respiratory tract
Label Pictograms: Health hazard, exclamation mark
GHS Signal Word: Warning
Chemical Name: Ethambutol Hydrochloride
Concentration: >98% by weight
Additives: None
Impurities: Trace organic impurities related to synthesis, residual solvents within accepted pharmaceutical limits
Molecular Weight: 277.22 g/mol
Inhalation: Move outside, support breathing as needed, seek medical care
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water
Eye Contact: Rinse eyes gently with water for at least 15 minutes, lift lids occasionally
Ingestion: Rinse mouth, do not induce vomiting, medical attention required
Advice for Physicians: Treat symptomatically, monitor visual function; consider possible delayed effects on optic nerve
Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray
Specific Hazards: Emits toxic fumes, including nitrogen oxides and hydrogen chloride, under fire
Protective Equipment: Full firefighting gear, self-contained breathing apparatus
Firefighting Procedures: Approach from upwind, control runoff, avoid inhalation of dusts and gases
Personal Precautions: Wear gloves, laboratory coat, dust mask or respirator, safety goggles
Containment: Avoid raising dust, use HEPA filter vacuum for clean-up
Clean Up: Place in closed containers for disposal, ventilate area, wash spill area with water and detergent
Environmental Precautions: Prevent substance from entering drains or watercourses by sequestering powder promptly
Handling: Use only in well-ventilated locations, minimize dust generation, avoid skin and eye contact, avoid ingestion
Storage: Keep container tightly closed in a dry, cool, and well-ventilated place, store away from strong oxidizing agents, acids, and moisture
Incompatibilities: Strong oxidizers, acids, and bases
Packaging: Use moisture-tight, light-resistant containers
Engineering Controls: Local exhaust or fume hood, negative pressure in storage areas
Respiratory Protection: NIOSH-approved respirator if exposure limits are exceeded or dust is generated
Eye Protection: Chemical splash goggles
Skin Protection: Nitrile gloves, long sleeves, lab coat
Other Protection: Avoid eating, drinking, or smoking during handling; wash hands thoroughly after use
Exposure Limits: No specific exposure limits established; minimize exposure to dust as a precaution
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: 3-5 (1% solution)
Melting Point: 205-210°C (decomposes)
Boiling Point: Not applicable
Solubility: Freely soluble in water, slight in ethanol, insoluble in ether
Vapor Pressure: Not measurable at ambient temperature
Partition Coefficient (log Pow): Not available
Density: Approx. 1.28 g/cm3
Chemical Stability: Stable in dry conditions and at room temperature
Reactivity: May react with strong oxidizers, acids, bases
Hazardous Polymerization: Will not occur
Decomposition Products: May emit toxic fumes of nitrogen oxides, hydrogen chloride, and carbon monoxide if heated to decomposition
Conditions to Avoid: Extreme humidity, heat, sources of ignition, and exposure to strong chemicals
Acute Toxicity: LD50 (oral, rat): ~3.3 g/kg
Chronic Toxicity: Repeated exposure affects vision, especially optic neuritis
Carcinogenicity: No confirmed evidence in humans
Sensitization: Possible allergic skin or respiratory reactions
Mutagenicity: None known from available data
Symptoms of Exposure: Visual disturbances, skin rash, stomach upset, cough, shortness of breath
Ecotoxicity: Limited data for specific effect on aquatic life
Persistence and Degradability: Expected to persist in soil and water, not readily biodegradable
Bioaccumulative Potential: Low, based on physical properties
Mobility in Soil: Water-soluble so likely to move through soil to groundwater
Other Adverse Effects: Not known to cause significant harm at therapeutic concentrations, still avoid large releases
Waste Disposal Methods: Handle as hazardous pharmaceutical waste, incinerate in approved facility
Unused Product: Send to a licensed disposal company
Contaminated Packaging: Triple rinse containers, dispose of in line with local regulations
Special Considerations: Container waste and material waste both need proper documentation and secure transport to disposal sites
UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Ethambutol Hydrochloride
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Special Precautions: Secure packaging to avoid spills, avoid exposure to moisture and rough handling during transport
Environmental Hazards: Not classed as marine pollutant
Transport in Bulk: Not applicable
Regulatory Status: Prescription medication, controlled under pharmaceutical regulations
Risk Phrases: R36/37/38: Irritating to eyes, respiratory system, and skin
Safety Phrases: S22: Do not breathe dust; S24/25: Avoid contact with skin and eyes
US Regulations: Not listed as hazardous by OSHA; handled under FDA requirements as an active pharmaceutical ingredient
European Union: Regulated under REACH and pharmaceutical directives
Other Regulations: Check local, state, and national requirements for handling, worker protection, and waste management
