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Product Name: Ethacridine Lactate / Ethacridine Lactate Monohydrate
Chemical Formula: C18H21N3O4.C3H6O3 (anhydrous); C18H21N3O4.C3H6O3.H2O (monohydrate)
CAS Number: 14897-39-3 (Ethacridine Lactate), 6402-23-9 (Monohydrate)
Common Synonyms: Rivanol, Acrinol lactate
Recommended Uses: Antiseptic, topical disinfectant, pharmaceutical ingredient
Supplier Information: Pharmaceutical chemical suppliers, hospital supply chains
Emergency Contact: Poison Control Centers, corporate safety departments, emergency medical services
Hazard Classification: Irritant, may cause eye and skin irritation, may be harmful if swallowed
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause respiratory tract irritation, prolonged contact leads to skin sensitization
Pictograms: Exclamation mark (for irritation)
Precautionary Statements: Avoid breathing dust or fumes, wash thoroughly after handling, wear protective gloves/eye protection
Health Effects: Inhalation may trigger cough or sore throat, ingestion causes gastrointestinal upset, skin contact leads to rashes in sensitive individuals
Symptoms of Exposure: Redness, itching, watering of eyes, mild nausea if swallowed
Chemical Name: Ethacridine Lactate Monohydrate
CAS Number: 6402-23-9
Concentration: 98-100%
Impurities: Small quantities of acridine derivatives, trace unreacted starting material
Molecular Weight: 473.5 g/mol (monohydrate)
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing until irritation subsides
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing and launder before reuse, seek medical attention for persistent irritation
Inhalation: Move person to fresh air, loosen tight clothing, seek medical advice if respiratory discomfort continues
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek immediate medical help and give water if victim is conscious
Most Important Symptoms: Irritation to eyes and skin, coughing, sore throat, nausea
Suitable Extinguishing Media: Water spray, CO2, dry powder, foam
Unsuitable Extinguishing Media: Strong water jets may spread chemical
Special Hazards: May generate toxic fumes (nitrogen oxides, carbon oxides) in a fire
Advice for Firefighters: Wear self-contained breathing apparatus, avoid inhaling smoke, use chemical-resistant gloves and protective gear
Combustion Products: Carbon monoxide, carbon dioxide, oxides of nitrogen, acridine fumes
Personal Precautions: Wear chemical-resistant gloves, safety goggles, lab coat, avoid breathing dust, work in well-ventilated area
Environmental Precautions: Prevent from entering drains, sewers, surface waters, notify authorities if significant quantities escape
Methods for Clean-up: Sweep up and place in suitable closed container for disposal, wash area with plenty of water, ventilate affected area
Decontamination: Clean with mild detergent and copious water, bag contaminated materials for approved disposal
Safe Handling Advice: Avoid contact with eyes, skin, and clothing, wash hands thoroughly after handling, minimize dust generation, use with local exhaust ventilation
Storage Conditions: Keep in tightly sealed container, store in cool, dry, well-ventilated place away from sunlight, incompatible chemicals, store at controlled room temperature (15–25°C)
Storage Incompatibilities: Strong oxidizers, acids, reducing agents
Special Handling Considerations: Do not eat, drink, or smoke when using, label container clearly
Occupational Exposure Limits: No established limits, use best practice industrial hygiene controls
Engineering Controls: Use local exhaust ventilation, handle inside chemical fume hood when possible
Personal Protective Equipment: Safety goggles, chemical-resistant gloves (nitrile, neoprene), lab coat, dust mask or particulate respirator for high dust situations
Hygiene Measures: Avoid eating or drinking in work area, wash hands and face after handling, launder clothing regularly
Appearance: Yellow crystalline powder
Odor: Odorless to faint medicinal smell
pH (1% solution): 4.5–6.5
Melting Point: 225–230°C (monohydrate)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water, sparingly soluble in ethanol
Density: ~1.3 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Not determined
Flash Point: Not flammable under typical conditions
Chemical Stability: Stable under normal conditions, sensitive to strong light
Reactivity: May react with strong oxidizing agents, acids
Conditions to Avoid: Excessive heat, direct sunlight, strong oxidizers
Hazardous Decomposition: Acridine fumes, nitrogen oxides, carbon monoxide, carbon dioxide
Polymerization: Not expected to occur
Routes of Exposure: Absorption possible through skin and eyes, inhalation, ingestion
Acute Toxicity: Oral LD50 in rats: >5000 mg/kg (low acute toxicity)
Chronic Effects: Prolonged skin contact may cause dermatitis, no evidence of carcinogenicity in supplied documentation
Symptoms: Gastrointestinal distress, headache, allergic skin reactions, conjunctivitis
Target Organs: Skin, eyes, respiratory tract, digestive tract
Mutagenicity/Carcinogenicity: No classified mutagenic or carcinogenic hazards
Ecotoxicity: Low water hazard in small quantities, avoid large-scale release
Aquatic Toxicity: Data not fully established but chemical belongs to a class that can be harmful to fish and other aquatic organisms at high concentration
Persistence and Degradability: Not persistent, will degrade slowly in the environment by microbial activity
Bioaccumulation: Low potential for bioaccumulation (based on solubility and molecular size)
Mobility in Soil: Expected to be moderately mobile due to water solubility
Other Adverse Effects: Discoloration of water possible
Waste Disposal Methods: Incinerate or dispose of in accordance with local, regional, national, and international regulations, do not allow to reach sewage or watercourses
Container Disposal: Rinse and dispose of containers as hazardous waste, follow environmental protection legislation
Special Precautions: Avoid generating dust, segregate chemical waste from other materials
UN Number: Not classified as hazardous for transport under most regulations
Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: No special labeling required unless large quantities shipped near waterways
Special Transport Precautions: Avoid rough handling, secure containers during transit
Chemical Regulatory Status: Not listed as controlled, subject to workplace safety and health regulations
OSHA: General duty to protect against chemical hazards, no specific listing
REACH/EU: Manufactured, imported, and used according to EU safety requirements
TSCA: Listed
WHMIS (Canada): D2B (Toxic, Irritant Substances)
Other Requirements: Maintain safety data sheets accessible to employees, provide appropriate labeling and training, comply with national chemical use and storage guidelines
