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Etamsylate Material Safety Data Sheet (MSDS)

Identification

Product Name: Etamsylate
Chemical Name: 2,5-dihydroxybenzene sulfonate ethanolamine
Synonyms: Dicynene, Ethamsylatum
CAS Number: 2624-44-4
Recommended Use: Hemostatic agent in pharmaceutical applications
Manufacturer: Contact information available through local supplier
Emergency Contact: Refer to local toxicology center or healthcare authority
Product Code: Varies by supplier and region

Hazard Identification

Classification: Not classified as hazardous under GHS for normal laboratory uses
Physical Hazards: Presents as a dust hazard if particles become airborne
Health Hazards: May cause irritation to eyes, skin, and respiratory tract if exposed in pure form
Label Elements: No standardized hazard pictograms for typical low-volume pharmaceutical contexts
Signal Word: None applicable for general handling, but prudent practices advised
Hazard Statements: Avoid inhalation, ingestion, and prolonged skin contact

Composition / Information on Ingredients

Chemical Name: Etamsylate
Purity: More than 99% (by pharmaceutical grade standard)
Molecular Formula: C10H17NO5S
Molecular Weight: 263.3 g/mol
Impurities: Trace levels of synthesis byproducts possible, determined by supplier quality statements
Other Components: May include excipients if supplied as tablet or injectable solution, refer to product label for details

First Aid Measures

Inhalation: Move exposed person to fresh air and monitor for symptoms such as coughing or shortness of breath; seek medical advice if symptoms persist
Skin Contact: Wash area with mild soap and generous amounts of water; medical advice recommended if irritation continues
Eye Contact: Rinse cautiously with clean water for several minutes; remove contact lenses if present and easy to do so
Ingestion: Rinse mouth, administer water if the individual is conscious; medical consultation preferred in all accidental ingestion scenarios
Most Important Symptoms: Redness, irritation, shortness of breath in rare cases
Notes to Physician: Treat symptomatically, consult product label for recommended interventions

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, water spray can be used safely
Unsuitable Extinguishing Media: Direct, high-pressure water streams could spread powder if large quantities stored
Special Fire Hazards: Decomposition in fire may produce sulfur oxides, nitrogen oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and standard personal protective equipment
Combustion Products: Irritating gases and smoke may result under fire conditions

Accidental Release Measures

Personal Precautions: Don protective gloves, safety goggles, and dust mask/respirator to limit inhalation and contact
Environmental Precautions: Prevent large spills from entering drains, sewers, and waterways
Containment Methods: Sweep up powder using industrial vacuum or dampen slightly to avoid dust formation
Cleaning Up: Dispose collected material in sealed containers labeled hazardous pharmaceutical waste

Handling and Storage

Safe Handling Advice: Avoid creating or inhaling dust, use mechanical ventilation or local extraction if handling powders
Storage Requirements: Store in cool, dry, and well-ventilated place; keep away from strong oxidizers, open flame, sources of heat
Incompatibilities: Strong acids, strong bases, and oxidizing agents may react with compound, avoid proximate storage
Shelf-Life Information: Check expiry date as indicated by manufacturer; segregation from food and incompatible chemicals essential

Exposure Controls and Personal Protection

Control Parameters: No occupational exposure limits designated for Etamsylate
Engineering Controls: Laboratory fume hood or localized exhaust recommended during bulk handling
Personal Protective Equipment (PPE): Nitrile gloves, safety goggles, lab coat; dust mask or respirator for airborne powder
Hygiene Measures: Wash hands thoroughly following laboratory work; remove contaminated clothing before leaving work area

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not established
pH: Typically neutral aqueous solutions, value depends on form and concentration
Melting Point: About 134°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Solubility: Readily soluble in water
Partition Coefficient: Not established
Vapor Pressure: Negligible
Density: Around 1.4 g/cm³
Viscosity: Not applicable to solid form
Other Properties: Non-explosive, non-volatile under ambient conditions

Stability and Reactivity

Chemical Stability: Stable under standard laboratory and storage conditions
Conditions to Avoid: Humidity, strong heat sources, direct sunlight, incompatible chemicals
Incompatible Materials: Strong oxidizers, mineral acids, bases
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides may be released in case of burning or decomposition
Polymerization: Does not occur under normal circumstances

Toxicological Information

Routes of Exposure: Oral, dermal, inhalation
Acute Toxicity: Low by oral route, LD50 (rat, oral) reported around 5 g/kg
Skin Corrosion/Irritation: May cause mild skin irritation on repeated or prolonged contact
Eye Damage/Irritation: Short-term exposures can produce mild eye discomfort
Respiratory Sensitization: Rare reports of hypersensitivity; avoid inhaling dust
Carcinogenicity: Not classified as carcinogenic by ACGIH, IARC, NTP, or OSHA
Mutagenicity: Negative in standard tests
Reproductive Effects: No evidence of teratogenic effects in animals at typical doses
Other Effects: Possible rare allergic response in predisposed individuals

Ecological Information

Ecotoxicity: Low toxicity to aquatic life at predicted environmental concentrations
Persistence and Degradability: Compound undergoes slow degradation in natural environments
Bioaccumulative Potential: Low mobility and low bioaccumulation observed in studies
Mobility in Soil: Readily water soluble, moderate mobility possible before breakdown
Other Adverse Effects: Not identified at typical environmental levels; pharmaceutical stewardship remains a priority

Disposal Considerations

Safe Disposal Method: Collect and place waste in sealed, labeled containers for incineration at licensed facility for pharmaceutical waste
Contaminated Packaging: Dispose of used containers as hazardous waste, following local regulations for pharmaceuticals
Disposal Precautions: Do not release to drains or environment; keep separated from non-hazardous waste streams

Transport Information

UN Number: Not regulated under most international transport rules for standard package sizes
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Non-hazardous for air, road, and sea
Packing Group: Not assigned
Special Precautions: Protect from moisture and physical damage during transit
Regulatory Notes: Mark and document shipments according to local law for pharmaceuticals, if required

Regulatory Information

Labelling: Compliant with regional regulations for pharmaceutical substances
Inventory Status: Listed in major chemical substance inventories (e.g., EINECS/ELINCS, TSCA, AICS)
Other Regulations: Subject to pharmaceutical handling and distribution controls in most regions
Restrictions: Clinical use restricted to prescription and medical supervision in many countries; laboratory use typically unregulated but best practices advised
SARA/Title III: Not listed as extremely hazardous by US EPA
REACH Status: Registration required for manufacture/import over threshold volumes into EU