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Product Name: Estrone
Chemical Name: Estra-1,3,5(10)-trien-17-one, 3-hydroxy-
CAS Number: 53-16-7
Synonyms: Oestrone, Folliculin
Recommended Use: Laboratory research, reference standard, pharmaceutical manufacture
Manufacturer: Listed on product label
Emergency Contact: Local poison control center or emergency service
Classification: Reproductive toxicity, Eye irritation, Skin irritation, Endocrine disruptor
Signal Word: Danger
Hazard Statements: May impair fertility. May cause harm to unborn child. Causes skin and eye irritation. May cause allergic skin reaction. Suspected of causing cancer.
Pictograms: Health hazard, Exclamation mark
Precautionary Statements: Avoid breathing dust. Wear protective gloves, clothing, and eye protection. Use only outdoors or in well-ventilated area. Wash thoroughly after handling. Do not eat, drink, or smoke when using this product. Store locked up away from children.
Chemical Name: Estrone
Concentration: ≥99%
Impurities: Trace organic solvents (<0.1%), moisture
Molecular Formula: C18H22O2
Molecular Weight: 270.37 g/mol
Inhalation: Move to fresh air. Provide artificial respiration if necessary, seek medical attention.
Skin Contact: Wash affected area with soap and water for at least 15 minutes. Remove contaminated clothing and wash before reuse.
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes, lifting eyelids occasionally. Seek immediate medical attention.
Ingestion: Do not induce vomiting. Rinse mouth with water. Seek immediate medical advice.
Acute Symptoms: Skin rash, eye redness, respiratory irritation, nausea, dizziness, hormonal effects
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: High-pressure water jet
Special Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Fire Hazards: Combustible, emits toxic fumes including carbon monoxide and carbon dioxide upon decomposition
Firefighting Instructions: Keep containers cool with water. Ventilate area. Remove all sources of ignition. Avoid inhaling gases or vapors.
Personal Precautions: Use personal protective equipment such as gloves, goggles, and face mask. Evacuate unprotected personnel.
Environmental Precautions: Prevent run-off into sewers, watercourses, or soil. Notify authorities about large spills.
Spill Containment: Avoid dust formation. Cover with inert absorbent material and collect for disposal. Place in suitable, labeled waste container.
Cleanup Procedures: Ventilate area, wash spill site after removal. Decontaminate tools and surfaces involved in cleanup.
Handling: Handle in a chemical fume hood. Avoid breathing dust or fumes. Use proper protective equipment at all stages. Wash hands and exposed skin thoroughly after handling.
Storage: Store in a tightly closed container in a cool, dry, well-ventilated area. Protect from light and incompatible substances such as strong oxidizers. Keep out of reach of untrained persons.
Incompatibilities: Strong acids, bases, oxidizing agents
Occupational Exposure Limits: Not established for estrone, minimize exposure to as low as reasonably achievable
Engineering Controls: Use process enclosures, local exhaust ventilation, and other engineering controls to maintain airborne levels below recommended exposure limits
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, laboratory coat, suitable respirator for powders or dust
Hygiene Measures: Wash thoroughly after handling, do not eat, drink, or smoke in laboratory areas
Appearance: White to off-white crystalline powder
Odor: None detectable
Melting Point: 254–257 °C
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water, soluble in ethanol, methanol, acetone, chloroform
pH: Not applicable
Vapor Pressure: Negligible at room temperature
Density: 1.21 g/cm3
Partition Coefficient (log Kow): 3.13
Flash Point: Not available
Auto-Ignition Temperature: Not available
Chemical Stability: Stable under recommended storage conditions
Possible Reactions: May react with strong oxidizing agents, acids, or bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, other toxic fumes under fire
Conditions to Avoid: Moisture, heat, sunlight, open flames, incompatible substances
Acute Toxicity: Oral LD50 (rat): >2,000 mg/kg
Routes of Exposure: Inhalation, ingestion, dermal, eye contact
Potential Health Effects: Irritation to skin, eyes, respiratory tract. Systemic absorption may disrupt normal hormonal balance, cause reproductive and developmental effects, or tumorigenic changes in animal studies.
Symptoms: Headache, dizziness, nausea, skin sensitization, menstrual irregularities, endocrine disturbance
Carcinogenicity: Classified as Group 2B (possibly carcinogenic to humans) by IARC.
Mutagenicity and Reproductive Effects: Evidence from animal models, limited human data
Chronic Exposure: Risk of endocrine disruption through repeated or prolonged contact
Target Organs: Endocrine system, liver, reproductive organs
Ecotoxicity: Highly toxic to aquatic organisms, potential for bioaccumulation in aquatic species. Disrupts normal endocrine function in fish and amphibians.
Persistence: Poorly biodegradable under typical environmental conditions
Bioaccumulation: Tendency to accumulate in aquatic life; log Kow indicates high mobility in fats
Mobility in Soil: Moderate, may leach into groundwater
Other Adverse Effects: No further relevant information available; reduce emissions to water systems.
Waste Disposal Methods: Dispose through licensed chemical waste disposal contractor. Do not incinerate in open flames.
Contaminated Packaging: Triple rinse containers before disposal. Dispose as hazardous waste.
Precautions: Do not release into the environment, sewer, or public water system. Comply with local, regional, and national regulations.
Recommended Recovery or Recycling: Whenever possible, minimize waste generation.
UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No, but avoid bulk transport near waterways
Special Precautions: Prevent spillage during transit, transport in sealed, labeled container out of direct sunlight
OSHA Status: Hazardous chemical according to OSHA Hazard Communication Standard
TSCA Status: Listed on TSCA Inventory
REACH Status: Registered, substances of very high concern due to endocrine-disrupting effects
SARA Title III: Not regulated under Sections 302, 304, or 313
California Proposition 65: Listed as chemical known to the State of California to cause cancer and reproductive toxicity
Other Applicable Regulations: Subject to IARC, ACGIH, federal and state regulations governing use, handling, and disposal
Safety, Health, and Environmental Regulations: Comply with all local, regional, and national S.H.E. requirements
