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Product Name: Estriol
Chemical Formula: C18H24O3
Chemical Family: Estrogen, Steroid
SYNONYMS: Oestriol, 16α-Hydroxyestradiol
CAS Number: 50-27-1
Manufacturer: Pharmaceutical laboratories and chemical suppliers globally
Intended Use: Hormone therapy, research, pharmaceutical synthesis
Emergency Phone: Local poison control or emergency response number
Product Code: Internal designation provided by supplier or manufacturer
GHS Classification: Reproductive toxicity, Specific target organ toxicity, Acute toxicity (oral, inhalation, skin exposure)
Signal Word: Warning
Hazard Statements: May cause reproductive harm, harmful if inhaled, ingested, or absorbed through the skin, can interfere with hormonal balance
Pictogram(s): Exclamation Mark, Health Hazard
Precautionary Statements: Avoid breathing dust, avoid contact with skin and eyes, do not eat, drink, or smoke when using this product
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
CHRONIC EFFECTS: Prolonged exposure may disrupt endocrine function, possible links to tumorigenicity noted in some studies
Chemical Name: Estriol
CAS Number: 50-27-1
Content: >97% pure (research or pharmaceutical grade)
Impurities: Trace levels of other estrogens and related steroids
Additive Components: None unless specified by formulation (for tablets or topical products, see product-specific sheets)
Inhalation: Move to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, rinse skin with water for at least 15 minutes
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, seek ophthalmologic review if irritation or abnormalities persist
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, get medical help promptly
Most Important Symptoms: Endocrine effects include nausea, headache, changes in mood, menstrual irregularities; acute irritation to eyes, skin, airways may occur
Suitable Extinguishing Media: Dry powder, carbon dioxide, foam, water mist
Unsuitable Media: Direct water jet
Hazardous Combustion Products: Carbon oxides, possibly acrid fumes and smoke
Special Protective Equipment: Self-contained breathing apparatus and full protective gear for firefighters
Advice for Firefighters: Keep upwind of fire, avoid inhalation of smoke or chemicals, control run-off to prevent contamination of water sources
Flammability: Estriol as a solid powder is combustible, though not highly flammable, should be kept away from open flames and ignition sources
Personal Precaution: Use appropriate personal protective equipment, ventilate area, avoid creating dust, avoid contact with skin, eyes, and clothing
Environmental Precaution: Prevent entry into sewers, surface water, or soil; notify relevant authorities in cases of significant release
Cleanup Methods: Absorb spill with suitable inert material, collect into closed containers for proper disposal, clean affected area with water and detergent, avoid dispersal
Decontamination: Wash exposed area with soap and water after cleanup, dispose of cleaning water as hazardous waste
Safe Handling: Handle in well-ventilated area, use local exhaust, reduce dust generation, avoid unnecessary exposure, prevent ingestion and inhalation
Storage Conditions: Store in tightly sealed containers, out of direct sunlight, in dry, temperature-controlled environment (recommended 2-8°C for long-term stability)
Segregation: Keep away from incompatible substances like strong oxidizers
Incompatible Materials: Strong acids, strong bases, strong oxidizing agents
Specific PPE During Handling: Nitrile gloves, lab coat, eye protection, and if powder form, a dust mask or respirator
Engineering Controls: Use chemical fume hood, local exhaust ventilation, containment enclosure for powder handling
Occupational Exposure Limits: No common threshold limit value listed (consult occupational health guidance for estrogenic compounds)
Personal Protection: Chemical-resistant gloves, safety goggles, laboratory coat. Respirator recommended for dust or aerosol exposure
Environmental Controls: Prevent release into the environment, use appropriate filters and waste disposal for lab effluents
Hygiene Measures: Wash hands after handling, do not eat, drink, or smoke during use, remove contaminated clothing and equipment promptly
Appearance: White to off-white crystalline powder
Odor: Odorless
Molecular Weight: 288.38 g/mol
Melting Point: 280–282°C (decomposes)
Solubility: Insoluble in water, soluble in ethanol, methanol, chloroform, slightly soluble in acetone
pH: Not applicable (neutral solid)
Boiling Point: Not available (decomposes before boiling)
Vapor Pressure: Negligible at ambient conditions
Partition Coefficient (log Kow): Approximately 2.5–3.0 reflective of moderate lipophilicity
Other Data: Non-volatile under ambient conditions
Chemical Stability: Stable under normal laboratory and storage conditions
Sensitivity: Sensitive to light, moisture, and air (prolonged exposure reduces potency)
Conditions to Avoid: Exposure to heat, direct sunlight, strong oxidizing environments
Incompatible Substances: Strong acids, strong bases, oxidizers
Hazardous Decomposition: Emits toxic fumes of carbon monoxide and carbon dioxide under fire conditions
Polymerization: Not reported to occur under normal use
Routes of Exposure: Skin, eyes, inhalation, ingestion
Acute Toxicity: No acute LD50 values widely available; assumed toxic based on related estrogens
Chronic Toxicity: Prolonged exposure may result in endocrine disruption, possible alteration of reproductive system
Carcinogenicity: No classification by IARC; high doses over long periods increase tumor risk in animal studies
Mutagenicity: No data suggesting mutagenicity at therapeutic or experimental concentrations
Teratogenicity: Possible teratogenic effects; restrict exposure in pregnancy
Local Effects: Skin and eye irritation, respiratory tract irritation at high concentrations
Aquatic Toxicity: Estriol enters aquatic systems from pharmaceutical runoff, disrupts hormonal systems in fish and amphibians
Persistence: Moderate persistence in aquatic environments, not readily biodegradable
Bioaccumulation: Potential for moderate bioaccumulation in aquatic organisms
Soil Impact: Low mobility in soil, possible impact on soil organisms if concentration is high
Other Effects: Contributes to eco-toxicological concerns related to hormone-active substances outside of intended use
Product Waste: Treat as hazardous pharmaceutical waste; utilize licensed chemical disposal contractor
Container Disposal: Rinse containers (if feasible), triple rinse recommended, dispose of in accordance with local regulations
Prohibited Methods: Do not discharge into drains or water bodies, avoid landfill disposal without validation
Best Practices: Incinerate under controlled conditions, retain disposal records
Local Regulatory Compliance: Adhere to national/regional waste disposal frameworks for controlled pharmaceuticals
UN Number: Not assigned unless specific bulk quantities
Transport Hazard Class: Not regulated as dangerous goods under ADR, RID, IMDG, IATA (came into play in specific formulations)
Packing Group: Not applicable for small laboratory/research shipments
Special Precautions: Protect from mechanical shock, moisture, and excessive heat
Transportation Label: Not required for basic laboratory packing, may require marking as pharmaceutical product
National Inventories: Listed under major chemical inventories (TSCA, EINECS/ELINCS as permitted pharmaceutical, not general industrial chemical)
REACH Status: Registered for specific pharmaceutical and research use across Europe
OSHA Hazard Classification: Considered hazardous under OSHA regulatory definitions for laboratory chemicals
Other Restrictions: Subject to prescription-only and controlled-use status in many jurisdictions
Labeling Requirements: Pharmaceutical labeling rules apply; additional hazard communication mandated in workplace context
