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Chemical Name: 17α-Estradiol
Synonyms: 17-Alpha-Estradiol, Estra-1,3,5(10)-triene-3,17α-diol
Molecular Formula: C18H24O2
CAS Number: 57-91-0
Application: Used in laboratory research, pharmaceutical synthesis, investigation of estrogenic activity in biological experiments
Supplier Details: Manufacturer and distributor details are usually provided on commercial packaging; maintain direct contact with responsible safety staff
GHS Classification: Reproductive toxicity (Category 1B), Skin sensitization (Category 1), Hazardous to the aquatic environment (Chronic Category 2)
Signal Word: Danger
Hazard Statements: May damage fertility or the unborn child; may cause an allergic skin reaction; harmful to aquatic life with long-lasting effects
Pictograms: Health hazard, Exclamation mark, Environment
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Possible Health Effects: Symptoms may include endocrine disruption, reproductive effects, skin sensitization reactions such as irritation or rashes
Precautionary Statements: Avoid breathing dust, prevent skin and eye contact, avoid release to the environment, use personal protection as described
Chemical Identity: 17α-Estradiol (100%)
Impurities and Stabilizing Additives: No significant impurities reported by most suppliers; refer to accompanying documentation for specific batch information
Concentration Range: Pure substance, no significant mixture with other chemicals intended
Molecular Weight: 272.38 g/mol
General: Move individual from exposure area into fresh air, assure comfort and seek professional attention if symptoms develop
Inhalation: Remove individual to uncontaminated air, loosen tight clothing, seek guidance from health personnel
Skin Contact: Remove any contaminated clothing, wash skin thoroughly with soap and water, monitor for persistent irritation, consult a dermatologist if redness or sensitivity occurs
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, remove contact lenses if present, consult an ophthalmologist
Ingestion: Rinse mouth, encourage drinking of water if person is conscious, do not induce vomiting, seek prompt medical care
Advice for Medical Personnel: Symptomatic treatment with special attention to possible hormone or reproductive effects
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: Full water jet could spread product residue
Hazardous Combustion Products: May emit carbon monoxide, carbon dioxide, and other unidentified organic compounds
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Fire and Explosion Hazards: Dust can potentially form explosive mixtures with air, avoid stirring up dust clouds
Advice for Firefighters: Evacuate room if necessary, use water spray to cool fire-exposed containers, contain water runoff to avoid environmental exposure
Personal Precautions: Use appropriate respiratory protection, gloves, and eye shield, contain spill to avoid dust formation, restrict access to site
Environmental Precautions: Prevent discharge to drains, surface or ground water, minimize environmental exposure by quick containment
Spill Cleanup Methods: Sweep or scoop up spilled product while avoiding dust, place material into sealed and labeled container for disposal, ventilate affected area
Decontamination: Thoroughly wash spill site with water and soap after removal of bulk material
Waste Disposal: Treat as hazardous waste with respect to reproductive toxicity, consult local disposal guidelines
Handling: Manipulate under an efficient local exhaust system or in a designated fume hood, minimize dust generation, avoid all direct physical contact with skin and mucous membranes
Personal Hygiene: Wash hands before eating, drinking, or smoking, change contaminated clothing
Storage Conditions: Store in tightly sealed containers, in cool, dry, well-ventilated location away from incompatible materials like strong oxidizers or acids
Temperature Recommendations: Preferred storage at 2-8°C, avoid exposure to direct sunlight or humidity
Segregation: Store separately from food, beverages, and animal feed
Control Parameters: Occupational exposure limits not established in most jurisdictions, use good industrial hygiene practices
Engineering Controls: Laboratory-grade ventilation such as chemical fume hoods, avoid recirculating air
Personal Protection: Certified particulate respirator if dusting occurs, nitrile or neoprene gloves, chemical splash goggles, laboratory coat
Skin Protection: Use chemically resistant gloves and protective sleeves if risk of skin contact
Eye/Face Protection: Wear appropriately rated safety goggles
Environmental Exposure Controls: Strict control of wastes and washings, limit drains and effluent discharge
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (practically insoluble in water)
Melting Point: 173-176°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, more soluble in ethanol, acetone, and chloroform
Vapor Pressure: Not significant at ambient conditions
Density: Approx. 1.2 g/cm³
Partition Coefficient (log Kow): Estimated at 3.94
Flash Point: Not available, product is not considered highly flammable
Chemical Stability: Stable under normal temperature and pressure when properly stored, may degrade under exposure to light or heat
Reactivity: Generally not reactive with standard laboratory materials
Conditions to Avoid: Prolonged exposure to elevated temperature, direct sunlight, and humidity
Incompatible Materials: Strong oxidizers, acids, alkalis
Hazardous Decomposition Products: Degradation can yield carbon oxides and various volatile organic fragments
Polymerization: No risk of hazardous polymerization identified
Acute Toxicity: Limited acute toxicity data; expected moderate toxicity by ingestion and injection based on studies in lab animals
Skin Corrosion/Irritation: Can sensitize skin, especially after repeated or prolonged exposure
Serious Eye Damage/Irritation: Direct contact may produce irritation
Respiratory Sensitization: Dust inhalation can irritate respiratory tract
Germ Cell Mutagenicity: Not identified as mutagenic by most standard test procedures
Carcinogenicity: Not classified as carcinogenic but related estrogens have shown tumorigenic effects in chronic exposure studies
Reproductive Toxicity: Clear evidence for reproductive toxicity; endocrine-disrupting potential seen in a range of vertebrate models
Specific Target Organ Toxicity: Estrogenic effects may impact hormone-regulated organs
Other Information: Potential effects on gender-specific tissues and functions; handle with special attention to vulnerable individuals
Aquatic Toxicity: Demonstrates moderate toxicity to aquatic organisms both acutely and on reproductive endpoints
Persistence and Degradability: Estimated to be partially persistent under typical environmental conditions, slow rate of natural degradation
Bioaccumulative Potential: Possesses a high partition coefficient, bioaccumulation can occur in aquatic species
Mobility in Soil: Low mobility in soil expected due to hydrophobic nature
Additional Hazards: Sensitive ecosystems, such as those involving amphibians or fish, may show developmental and reproductive disturbances on chronic exposure
Disposal Impact: Uncontrolled releases pose ecological risks, particularly to watercourses and wetlands
Waste Disposal: Treat as hazardous waste; incineration in a chemical incinerator with afterburner and scrubber usually preferred method
Container Disposal: Rinse empty containers with compatible solvent followed by extensive water washing, submit as hazardous material
Legal Considerations: Comply with regional, national, and local regulations for substances identified as toxic or endocrine-disrupting
Environmental Release: Never flush product or significant residues to natural waterways, sewers, or general refuse
Recycling: Not suitable for chemical recycling due to toxicity and persistence
UN Number: Not assigned by UN for most jurisdictions
Transportation Hazard Class: Not classified as dangerous goods under most international transport regulations; check for updates
Packing Group: Not assigned
Marine Pollutant: Considered a potential marine pollutant due to aquatic toxicity; handle with care during bulk shipments
Special Precautions: Secure containers tightly, label with reproductive toxicity warning, maintain records of transfer
Other Regulatory Schemes: Local rules on transferring laboratory chemicals may impose additional notification or packaging requirements
EU Regulations: Listed in REACH Regulation – substances of very high concern under evaluation for reproductive toxicity
US TSCA: Subject to reporting in some research settings, not broadly regulated for industrial use
OSHA Status: Not specifically regulated, general lab safety standards apply
Canada DSL/NDSL: Not listed in some regions, refer to local schedules
Additional Country-Specific Laws: Some regions restrict or track use due to concern over environmental or worker health; confirm with local competent authority
Worker Protection: Limit workplace exposure via procedural and engineering controls, maintain Material Safety Data Sheet availability at point of use
Labeling Requirements: Product labels must reflect reproductive toxicity classification, risk and safety advisories
