© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Chemical Name: Estradiol Acetate
Other Names: 17β-Estradiol 3-acetate
Chemical Formula: C20H26O3
Common Use: Medication for hormone therapy, active pharmaceutical ingredient in various estrogen products
Form: Usually appears as a white or off-white crystalline powder
CAS Number: 701-49-5
GHS Classification: Reproductive toxicity, potential carcinogen, endocrine disruptor
Hazard Statements: May interfere with fertility and fetal development, causes irritation to skin and eyes, may cause allergic skin reaction, suspected of causing cancer
Skin Contact Risk: Risk of absorption and irritation
Inhalation Risk: Can cause respiratory irritation if dust is inhaled
Main Ingredient: Estradiol Acetate (purity typically exceeds 98%)
Impurities: Trace quantities of related steroids and residual solvents
Mixtures: Sometimes found blended in excipients for pharmaceutical formulations
Inhalation: Move to fresh air, ensure clear airway, seek medical attention for persistent symptoms
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, seek care for redness or irritation
Eye Contact: Rinse with gentle stream of water for at least 15 minutes, seek medical check-up if discomfort continues
Ingestion: Rinse mouth, never induce vomiting, get urgent medical evaluation
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam
Hazardous Combustion Products: May generate toxic fumes like carbon monoxide and carbon dioxide
Protective Equipment: Full protective clothing and self-contained breathing apparatus, limit exposure to smoke
Specific Dangers: Dust can form explosive mixtures with air under extreme conditions
Personal Precautions: Use gloves and protective clothing, avoid dust generation, ventilate area
Spill Cleanup: Sweep or vacuum up into a container with care to prevent powder dispersal, wash spill site after cleanup
Environmental Precautions: Keep away from drains, sewers, and soil to prevent hormone contamination
Handling Practices: Reduce dust, avoid skin and eye contact, wash hands after use
Storage Methods: Closed containers, cool dry area, away from light and incompatible substances like strong oxidizers
Segregation: Separate from food, beverages, and animal feed
Engineering Controls: Use local exhaust ventilation, fume hoods for large volumes
Personal Protective Equipment: Chemically resistant gloves, lab coats, safety goggles, respirators for dusty environments
Hygiene Measures: No eating or drinking near the material, wash thoroughly after handling
Appearance: White or almost white crystalline solid
Odor: Odorless
Melting Point: Approximately 173-175°C
Solubility: Slightly soluble in water, better solubility in alcohol, chloroform, and other organic solvents
Stability: Stable under recommended storage conditions, sensitive to excessive heat and light
Chemical Stability: Stable at standard temperature and pressure
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Decomposition Products: Burning produces carbon oxides and possibly other toxic fumes
Hazardous Reactions: Unlikely under normal handling, but hazardous reactions may occur if mixed with incompatible substances
Acute Toxicity: Toxic in large doses by ingestion, inhalation, or skin absorption
Health Effects: Estrogenic effects on human reproductive system, endocrine disruptions, increased risk of certain cancers after chronic exposure
Allergic Reactions: Some individuals may develop skin sensitization or allergic dermatitis
Long-term Consequences: Prolonged exposure linked with hormone imbalance and possible tumor development
Aquatic Toxicity: Harmful to aquatic organisms, causes hormonal disruption in fish and amphibians
Persistence: May not degrade rapidly in environment, risk of bioaccumulation in water bodies
Precaution: Avoid release to natural waters to limit ecosystem risks
Waste Handling: Gather material in sealed container for chemical waste disposal
Method: Send to authorized facility capable of safe destruction of pharmaceuticals, do not landfill or pour down drains
Precaution: Incinerate in accordance with local, state, and national regulations for hazardous medical waste
UN Number: Typically not regulated as a hazardous material for transport in small quantities, but always verify with local authorities
Packaging: Use secondary containment, keep separated from incompatible substances during shipping
Precautions: Prevent container rupture, label packages clearly to indicate medical compound
OSHA Status: Regulated for laboratory safety in the United States
TSCA: May not be listed for general industrial use, check specific guidelines
Other Regulations: Estradiol is regulated as a prescription drug in most regions, restricted for use outside of medical applications, included on lists of hazardous pharmaceuticals in water management regulatory bodies
