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Product Name: Estra-4,9-Diene-3,17-Dione
Synonyms: Trenavar, Trenbolone Precursor
Chemical Formula: C18H20O2
Molecular Weight: 268.35 g/mol
CAS Number: 4642-95-9
Recommended Use: Research and laboratory use
Supplier: Chemical suppliers for research or academic use
Emergency Number: Refer to local poison control and emergency medical services
GHS Classification: Acute Toxicity (Oral) Category 4, Eye Irritation Category 2, Reproductive Toxicity Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes serious eye irritation; suspected of damaging fertility or the unborn child
Precautionary Statements: Do not breathe dust; wash hands thoroughly after handling; wear protective gloves, clothing, and eye protection; avoid release to the environment
Pictogram: Exclamation mark, Health hazard
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Irritation of eyes and mucous membranes, abdominal discomfort, possible reproductive toxicity
Chemical Name: Estra-4,9-Diene-3,17-Dione
Concentration: >98% (pure form)
Impurities: Trace organic and inorganic residues, typically below 2%
Stabilizers or Additives: None present in pure reagent
Formulation: Solid powder, yellow or off-white in color
Inhalation: Remove person to fresh air; seek medical attention for difficulty breathing or persistent symptoms
Ingestion: Rinse mouth with water, do not induce vomiting; consult medical provider if symptoms appear
Skin Contact: Remove contaminated clothing, wash skin with soap and water; seek care if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses; obtain medical help if pain persists
Most Important Symptoms: Eye redness, burning sensation, gastric irritation, skin dryness or rashes
Notes to Physician: Treat symptomatically, monitor for endocrine disruption
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Unsuitable Extinguishing Media: Water jet can spread powder
Specific Hazards: Fine powder may form combustible dust-air mixtures
Hazardous Combustion Products: Carbon oxides, irritating organic vapors
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus; isolate hazard area
Personal Precautions: Avoid dust inhalation, provide adequate ventilation, wear suitable PPE
Environmental Precautions: Prevent entry into drains, sewers, or surface water
Cleanup Methods: Carefully sweep up or vacuum spillage, place in sealed container for safe disposal
Decontamination: Wash affected area with water and detergent; ventilate the site
Disposal of Contaminated Materials: Handle as hazardous chemical waste; comply with local regulations
Safe Handling: Use in well-ventilated area, avoid generation of dust; prevent skin and eye contact
Hygiene Measures: Wash hands after handling, avoid eating or drinking during use
Storage Conditions: Store tightly closed, away from heat and direct sunlight, in dry well-ventilated place
Incompatible Materials: Strong oxidizers, reducing agents
Packaging Materials: Resealable containers made of glass or high-density polyethylene
Occupational Exposure Limits: Not established for this specific compound
Engineering Controls: Local exhaust ventilation, laboratory fume hood
Personal Protective Equipment: Nitrile gloves, safety goggles, lab coat
Respiratory Protection: NIOSH-approved respirator if dust or aerosols are generated
Environmental Control: Prevent release to natural waterways and public sewers
Hygiene Practices: Avoid contact with skin, eyes; remove contaminated clothing after use
Appearance: Yellow or off-white crystalline powder
Odor: Odorless or faint chemical smell
Odor Threshold: Not determined
pH: Not applicable (insoluble in water)
Melting Point: 183 - 185°C
Boiling Point: Not available (decomposes before boiling)
Flash Point: Not determined for solid
Flammability: May form combustible dust clouds
Vapor Pressure: Negligible
Solubility: Practically insoluble in water; soluble in organic solvents (chloroform, ethanol)
Partition Coefficient (log Kow): Not available
Decomposition Temperature: Above melting point
Viscosity: Not applicable
Reactivity: Stable under recommended storage conditions
Chemical Stability: No significant decomposition at ambient temperature
Potentially Hazardous Reactions: Reacts with strong oxidizing agents
Conditions to Avoid: Excessive heat, moisture, direct sunlight, and static discharge
Incompatible Materials: Oxidizing and reducing substances, acids
Decomposition Products: Carbon monoxide, carbon dioxide, other toxic gases
Acute Toxicity: Oral LD50 (rat): not established; harmful if swallowed and may pose toxic risk at higher doses
Skin Corrosion/Irritation: May cause irritation after prolonged or repeated contact
Serious Eye Damage/Irritation: Causes irritation with redness and tearing
Respiratory Sensitization: Dust may irritate respiratory tract
Germ Cell Mutagenicity: No reliable studies available
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: Suspected risk based on structure-activity, related compounds affect fertility
Specific Target Organ Toxicity: Possible risk to endocrine organs
Chronic Effects: Repeated exposure may lead to reproductive hormone impact, changes in mood or behavior
Ecotoxicity: No specific data available; compounds with endocrine-modulating effects may disrupt aquatic life
Persistence and Degradability: Expected to be poorly biodegradable; may persist in soil or sediment
Bioaccumulative Potential: Potential for bioaccumulation due to lipophilicity
Mobility in Soil: Low mobility, significant absorption to particulate matter
Other Adverse Effects: Unknown effects on higher organisms and ecosystems
Avoid Release: Best practice keeps this compound out of wastewater streams and natural bodies of water
Waste Treatment Methods: Chemical must be disposed of as hazardous organic waste
Packaging Disposal: Decontaminate and dispose of in accordance with official regulations
Disposal Precautions: Avoid incinerating without proper control; prevent release to environment
Local Regulation Compliance: Consult local and national hazardous waste rules
Preferred Disposal Route: High-temperature incineration in permitted facility
UN Number: Not regulated for ground, sea, or air freight
UN Proper Shipping Name: Not established
Transport Hazard Class: Not assigned
Packing Group: Not established
Environmental Hazards: Not marine pollutant, though not recommended for bulk transportation
Special Precautions: Store and transport in leak-proof, inert containers; avoid rough handling
US Federal Regulations: Not listed on EPA TSCA; not classified as a controlled substance, but subject to specific state and research regulations
EU Regulation (REACH): Not registered; intended for research use only
OSHA/WHMIS: Not specifically regulated, treat as hazardous chemical
Safety Assessment: Requires risk assessment and control measures for occupational exposure
Label Requirements: Hazard warnings and safety information visible on all containers
Restrictions: Not for use in food, drug, cosmetic, or household applications
