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Name: Erythromycin Estolate
Chemical Class: Macrolide antibiotic, ester form of erythromycin
Common Use: Treatment of specific bacterial infections
Appearance: White to off-white powder or crystalline solid
Odor: Faint or no distinct odor
Molecular Formula: C52H97NO18S
CAS Number: 3521-62-8
Health effects: Ingestion sometimes causes stomach pain, nausea, diarrhea, or allergic skin reactions. Sensitive groups, especially those with liver issues, may react more severely.
Inhalation risk: Dust can cause irritation to the nose and throat.
Eye contact: Dust may sting or burn the eyes.
Skin contact: Direct exposure may cause mild irritation or rash.
GHS Classification: Not classified as a carcinogen or mutagen, but can provoke allergies in some cases.
Labeling: Avoid direct contact, particularly if sensitive to macrolide antibiotics.
Active Ingredient: Erythromycin Estolate, typically over 95 percent purity in pharmaceutical preparations
Impurities: Trace amounts of related macrolide compounds
Excipients: May contain binders or fillers if presented as a tablet or capsule
Inhalation: Move person to fresh air, keep at rest, and seek medical advice if signs of distress appear.
Skin contact: Remove contaminated clothing, wash affected area with soap and water. Call medical help if irritation persists.
Eye contact: Rinse carefully with water, holding eyelids open. Seek attention if discomfort continues.
Ingestion: Rinse mouth if conscious. Medical evaluation is a smart call if symptoms occur.
Extinguishing media: Use water spray, dry chemical, foam, or carbon dioxide.
Hazards from combustion: Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides.
Protective clothing: Firefighters use full protective gear and self-contained breathing apparatus to avoid inhaling smoke.
Special procedures: Evacuate area and prevent runoff from contaminating water supplies.
Personal protection: Gloves, dust masks, and eye protection reduce risk from exposure.
Spill cleanup: Scoop or sweep material into a sealable container, minimize dust, and ventilate work area.
Disposal: Dispose of according to local environmental requirements for pharmaceutical waste.
Environmental precautions: Avoid waste release into waterways or drains.
Handling: Work in well-ventilated areas and avoid generating dust. Good hygiene includes regular handwashing.
Storage: Store in a cool, dry spot away from sunlight and moisture. Closed containers keep the powder stable longer.
Incompatibilities: Avoid contact with strong acids, bases, and oxidizing agents.
Precautions: Keep out of reach of children and those with allergies to macrolides.
Engineering controls: Use local exhaust ventilation or work inside a fume hood when handling powders.
Personal protection: Protective non-permeable gloves, safety goggles, and dust mask recommended, especially for those with chemical sensitivities.
Hygiene: Wash hands before meals and after handling the material. Remove and wash contaminated clothing.
Workplace monitoring: Keep airborne dust to a minimum for the comfort and safety of staff.
Form: Solid, powder or crystalline
Color: White to faintly yellow
Solubility: Slightly soluble in water, soluble in alcohol and organic solvents
Melting Point: Decomposes without melting at high temperatures
Odor: No strong odor
Chemical stability: Stable under normal conditions, dry and cool storage maintains potency.
Conditions to avoid: Direct sunlight, extreme heat, and moisture degrade the compound.
Materials to avoid: Strong oxidizers, acids, and bases
Decomposition products: Heating may yield toxic vapors like CO, CO2, and nitrogen or sulfur oxides.
Acute toxicity: Low for most healthy adults, but children and sensitive groups may experience gastrointestinal upset or allergy.
Chronic effects: Prolonged or repeated contact sometimes triggers skin sensitization. Reported rare cases of liver toxicity, especially for those with pre-existing conditions.
Allergenic potential: Allergic reactions such as rash or breathing difficulty. Known cross-sensitivity with other macrolide antibiotics.
Inhalation: Dust inhalation may lead to coughing or throat irritation over time.
Aquatic toxicity: Known to impact algae and aquatic organisms even in small amounts
Persistence: Environmental breakdown may be slow; antibiotics risk disrupting wastewater treatment and aquatic soil bacteria
Bioaccumulation: Unlikely to build up in food chains but should not be treated as harmless
Precaution: Limit environmental release as many municipal plants cannot fully degrade antibiotics.
Preferred disposal: Treat as pharmaceutical waste with incineration for bulk quantities.
Household amounts: Return unused or expired drugs to pharmacy take-back programs; avoid flushing or landfill.
Regulatory guidance: Follow local environmental laws and best practices to prevent unwanted antibiotic in water or soil.
Transport classification: Not considered hazardous for land, air, or sea shipment under most international rules
Packaging: Keep in sealed, labeled containers away from food, feed, and children
Precautions: Secure loads to avoid spills and accidental release
Pharmaceutical regulations: Falling under rules for controlled antibiotics in many countries, subject to prescription status for medical use
Occupational rules: Covered by workplace chemical safety regulations; local workplace authorities may set limits on occupational exposure
Environmental standards: Limits on antibiotic discharge in wastewater required in places with advanced environmental laws
Consumer safety: Clear labeling and safety instructions are important for public confidence and safety
