© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Epothilone A
Chemical Family: Macrolide lactone
Synonyms: Natural cytotoxic macrolide, NSC 706257
CAS Number: 153491-84-6
Molecular Formula: C27H41NO6S
Recommended Use: Research and laboratory applications
Supplier: Contact the manufacturing or distribution company listed on the product label
Emergency Contact: Refer to local poison control center or hazardous material response team
Classification: Acute toxicity (oral), skin and eye irritant, specific target organ toxicity
Signal Word: Warning
Hazard Statements: May cause eye, skin, and respiratory irritation. Possible damage to health by inhalation, ingestion, or skin exposure. May affect nervous and immune systems.
Pictograms: GHS07 (exclamation mark), GHS08 (health hazard)
Precautionary Statements: Avoid breathing dust or vapors. Wear protective gloves and eye protection. Wash hands thoroughly after handling. If exposed, seek medical advice.
Chemical Name: Epothilone A
CAS Number: 153491-84-6
Concentration: 98-100% (pure solid form)
Impurities: Potential trace amounts of structurally related macrolides as byproducts
Inhalation: Move person to fresh air. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing and rinse skin thoroughly with soap and water. Consult a physician if irritation occurs.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids. Remove contact lenses if present and easy to do. Get immediate medical help.
Ingestion: Rinse mouth with water. Never give anything by mouth to an unconscious person. Contact physician or poison center immediately.
Symptoms and Effects: Irritation, dizziness, difficulty breathing, allergic response, nausea.
Suitable Extinguishing Media: Dry powder, carbon dioxide, alcohol-resistant foam. Avoid large volumes of water.
Special Hazards Arising: Emits toxic fumes including carbon oxides, nitrogen oxides, and sulfur oxides on combustion.
Protection for Firefighters: Full protective equipment with self-contained breathing apparatus.
Thermal Decomposition: Hazardous decomposition, especially in confined areas.
Personal Precautions: Evacuate unnecessary personnel. Wear gloves, safety goggles, and a laboratory coat.
Environmental Precautions: Prevent further leakage or spillage if safe. Avoid runoff into surface waterways.
Clean-up Methods: Carefully collect spilled solid without generating dust. Place in a secure waste container for proper disposal. Ventilate area and wash site after material pickup is complete.
Precautions: Use only in a chemical fume hood or well-ventilated area. Avoid contact with skin, eyes, and clothing. Prohibit eating, drinking, and smoking in working area.
Storage Conditions: Store in tightly closed container, away from light, moisture, and incompatible substances. Maintain at -20°C or below if possible. Label containers clearly.
Technical Measures: Install safety showers and eyewash stations in immediate work area.
Engineering Controls: Use fume hoods or local exhaust ventilation. Maintain low exposure concentrations.
Personal Protection: Chemical resistant gloves (nitrile recommended). Protective lab coat. Safety goggles or face shield. Respirator recommended if dust or aerosol generation likely.
Hygiene: Wash hands and forearms thoroughly after handling. Remove contaminated clothing and wash before reuse.
Control Parameters: No occupational exposure limits provided specifically for this substance. Use general duty limits for laboratory chemicals.
Physical Form: White to off-white crystalline powder
Odor: Odorless
Melting Point: 165–168°C
Boiling Point: Decomposes prior to boiling
Solubility: Soluble in organic solvents such as methanol, ethanol, DMSO; low solubility in water
pH: Not applicable (not water soluble)
Vapor Pressure: Negligible at room temperature
Flash Point: Data not available
Partition Coefficient: No data provided
Molecular Weight: 487.68 g/mol
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with acids, strong oxidizing agents, alkali metals
Hazardous Decomposition Products: Produces toxic gases and fumes including carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides during thermal decomposition
Conditions to Avoid: Moisture, high temperature, direct sunlight, incompatible chemicals
Polymerization: Not expected to occur
Acute Toxicity: Limited animal data; ingestion, inhalation, or skin exposure may cause harmful effects.
Routes of Exposure: Ingestion, inhalation, skin, and eye contact
Symptoms: Drowsiness, difficulty breathing, nausea, headache, dermatitis, eye irritation
Chronic Effects: Repeated exposure may lead to nervous system effects, immune response alterations.
Carcinogenicity: No classification available from NTP, IARC, or OSHA.
Mutagenicity: Laboratory studies suggest possible mutagenic potential.
Sensitization: May cause allergic reactions after repeated contact.
Further Information: Handle as a chemical with unknown toxicity; not for drug or food use outside of research settings.
Ecotoxicity: Data lacking on aquatic and soil environments. Possibility of bioaccumulation and toxicity to aquatic organisms based on mechanism of action.
Mobility in Soil: Variable; lipid-soluble properties may increase persistence.
Persistence and Degradability: Not readily biodegradable; significant risk if released into environment.
Bioaccumulation: Potential for accumulation in organisms.
Additional Notes: Limit environmental release. Collect and dispose of contents using licensed hazardous waste contractor.
Waste Treatment Methods: Collect and label as hazardous chemical waste.
Product Disposal: Use incineration at licensed facility, according to local and national regulations.
Contaminated Packaging: Triple rinse, puncture, and dispose of as hazardous waste.
Precautions: Never dispose in sink or general refuse. Consult hazardous waste disposal company for compliance with local control laws.
UN Number: Not assigned for this substance
UN Proper Shipping Name: Not regulated for transport under global transport rules
Transport Hazard Class: No specific classification
Packing Group: Not applicable
Environmental Hazards: Handle with caution to avoid environmental contamination
Special Precautions for User: Keep packaging intact, sealed, and protected from rough handling and moisture
US TSCA: Substance not listed for commercial applications
OSHA Hazard Communication: Classified as hazardous
SARA Title III (Sections 311/312): Acute health hazard
REACH Registration: Not registered for commercial or industrial applications in Europe
Disposal Regulations: Must follow all state, federal, and local hazardous waste requirements
WHMIS Classification (Canada): D2B toxic material causing other toxic effects
Other Regulations: Product for laboratory use only; not authorized for medical, diagnostic, or household purposes outside controlled protocols
