© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Norepinephrine Hydrochloride
Synonyms: Levonorepinephrine hydrochloride, Noradrenaline hydrochloride
CAS Number: 329-63-5
Molecular Formula: C8H11NO3·HCl
Molecular Weight: 209.64 g/mol
Intended Use: Laboratory research, pharmaceutical manufacturing
Manufacturer: Pharmaceutical manufacturers and chemical suppliers distribute it globally
Emergency Contact: Refer to local Poison Control Center or emergency medical services
GHS Classification: Acute toxicity (oral), Category 3; Skin sensitizer, Category 1; Eye irritation, Category 2A
Signal Word: Danger
Hazard Statements: Toxic if swallowed, may cause an allergic skin reaction, causes serious eye irritation
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves, clothing, and eye protection
Pictograms: Skull and crossbones, exclamation mark
Physical Hazards: Not combustible, but may decompose at high temperatures
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Target Organs: Cardiovascular system, nervous system, skin, eyes
Chemical Name: Norepinephrine Hydrochloride
Concentration: >98% (typical pure substance)
Impurities and Stabilizing Additives: Trace amounts of related catecholamines possible depending on synthesis
CAS Number: 329-63-5
EC Number: 206-350-2
General Advice: Remove from exposure source immediately; seek prompt medical attention
Inhalation: Move to fresh air, keep victim at rest, consult a physician if symptoms persist
Skin Contact: Remove contaminated clothing, wash exposed area with soap and water for at least 15 minutes. Seek medical advice if irritation develops or persists
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids. Remove contacts if present and easy to do. Get medical care
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, seek medical attention immediately
Symptoms/Effects: Palpitations, headache, hypertension, local skin or eye irritation, possible allergic reactions
Advice for Physicians: Treat symptomatically, monitor vital signs, consider catecholamine toxicity
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Direct water jets can spread dust
Fire Hazards: Decomposition may release toxic fumes of nitrogen oxides, hydrogen chloride, carbon monoxide
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Special Precautions: Evacuate area, contain runoff water to prevent entry into sewers
Explosion Data: Not sensitive to mechanical impact, not prone to static discharge
Personal Precautions: Avoid inhalation of dust, avoid skin and eye contact, use personal protective equipment like gloves, goggles, masks
Environmental Precautions: Prevent material from entering drains, surface or ground water; inform authorities if large amounts spill
Methods for Cleanup: Carefully sweep or scoop up without generating dust, place in suitable container for disposal, ventilate area, wash spill site with water and detergent after material pickup
Decontamination: Use water and mild detergent for effective cleanup of contaminated surfaces
Disposal: Waste collected should be managed as hazardous chemical waste, handled by trained professionals, labeled accordingly
Precautions for Safe Handling: Prevent dust formation, use recommended personal protective equipment, avoid contact with skin, eyes, and clothing
Safe Storage Conditions: Store in tightly closed container, in a cool, dry, well-ventilated area, away from incompatible substances (strong oxidizers and acids)
Protection from Light and Moisture: Protect from light and humid air to maintain stability
Handling Notes: Only trained personnel should handle concentrated forms, follow lab safety protocols, keep away from food and drink
Incompatibilities: Reacts with strong acids, oxidizing agents
Occupational Exposure Limits: No specific limits assigned in OSHA, ACGIH, or NIOSH, but exposure should be kept as low as possible
Engineering Controls: Use chemical fume hood, local exhaust ventilation
Personal Protective Equipment: Impervious gloves, lab coat or gown, chemical safety goggles, face shield if potential for splashing, NIOSH-approved dust mask or respirator if airborne concentrations may be generated
Hygiene Measures: Wash hands before breaks and at end of work shift, remove contaminated clothing immediately, avoid eating or drinking in work area
Environmental Controls: Prevent workplace release to environment by using closed handling systems and spill protection
Physical State: Solid, crystalline powder
Color: White to off-white
Odor: Odorless
Melting Point: 147-151°C
Boiling Point: Decomposes before boiling
Solubility: Freely soluble in water
pH: Typically acidic in solution
Vapor Pressure: Negligible at ambient temperature
Density: Not specified in open literature, typical for similar hydrochloride salts
Partition Coefficient (log Kow): Not expected to bioaccumulate due to hydrophilicity
Stability to Light: Degrades under direct light exposure, store away from light
Chemical Stability: Stable at recommended handling and storage conditions
Conditions to Avoid: Excessive heat, direct sunlight, exposure to moisture
Materials to Avoid: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride gas, carbon monoxide, carbon dioxide
Polymerization: Not known to occur under standard conditions
Reactivity: Not considered highly reactive, but unstable with incompatible materials
Acute Toxicity: Oral LD50 (rat) estimated below 100 mg/kg; toxic and potentially fatal at high doses
Routes of Exposure: Inhalation, skin, eye, ingestion
Symptoms: May cause hypertension, tachycardia, cardiac arrhythmias, local irritation, allergic responses, headache, sweating
Chronic Effects: Prolonged or repeated exposure can lead to sensitization, cardiovascular disturbances, and possible organ toxicity
Carcinogenicity: Not listed by OSHA, IARC, NTP as carcinogen
Mutagenicity: Data limited; in vitro studies suggest possible DNA effects at high doses
Reproductive Toxicity: No evidence in available documentation, but use caution during pregnancy or lactation
Additional Information: Pharmaceutical-grade norepinephrine is used therapeutically under strict clinical supervision; toxic for unregulated experimental use
Ecotoxicity: Limited data available; expected to have low acute aquatic toxicity as catecholamines degrade rapidly
Persistence and Degradability: Biodegradable under normal environmental conditions, unstable in outflow or sunlight
Bioaccumulation Potential: Very low due to high water solubility and rapid metabolism
Mobility in Soil: Moves readily in water systems
Other Adverse Effects: At high concentrations, can disrupt aquatic microbial activity
Precautions: Prevent release to surface waters and sewer systems
Waste Treatment Methods: Incinerate in approved chemical incinerator with afterburner and scrubber, or manage as hazardous chemical waste according to local, regional, and national regulations
Contaminated Packaging: Rinse thoroughly before recycling or disposal; handle as hazardous waste
Special Precautions: Do not discharge into waterways, storm drains, or soil
Disposal Guidance: Use fully licensed chemical waste disposal contractor; document and label waste stream accurately
UN Number: Not assigned a specific UN number
UN Proper Shipping Name: Chemical, not otherwise specified
Transport Hazard Class: Not regulated as dangerous goods under ADR, IMDG, IATA in small quantities
Packing Group: Not applicable
Environmental Hazards: Prevent uncontrolled release during shipping; packed to protect from water or light exposure
Special Precautions for Users: Follow state and federal requirements for laboratory chemicals in transit
TSCA Inventory: Not listed for general commercial use
EU REACH Status: Exempt as medicinal product active ingredient
OSHA Status: Not specifically regulated by OSHA as hazardous chemical, but handled under lab safety standard
WHMIS Classification (Canada): Classified as Toxic, Skin Sensitizer
California Proposition 65: Not listed
Other Regulations: Controlled substance in some jurisdictions due to pharmaceutical application; trade and use subject to various national and international drug regulations
Label Requirements: Apply hazard pictograms, precautionary statements, and emergency contacts as dictated by region
