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Product Name: Emetine Hydrochloride
Chemical Formula: C29H40Cl2N2O4
CAS Number: 316-42-7
Synonyms: Emetine HCl, Methylcephaeline hydrochloride
Recommended Use: For laboratory, research, and pharmaceutical applications only
Supplier Information: Refer to product container or trusted supplier for emergency contact details and address
Emergency Phone Number: Refer to national or local poison control authorities for rapid response
Classification (GHS): Acute Toxicity—Oral (Category 2), Acute Toxicity—Dermal (Category 2), Acute Toxicity—Inhalation (Category 2), Eye Irritation (Category 2A)
Signal Word: Danger
Hazard Statements: Fatal if swallowed, in contact with skin, or inhaled; causes serious eye irritation; toxic to aquatic life
Pictograms: Skull and crossbones, exclamation mark, environment
Precautionary Statements: Avoid breathing dust, wear protective gloves, eye protection, wash hands thoroughly after handling, avoid release to environment
Routes of Exposure: Ingestion, inhalation, dermal contact, ocular contact
Potential Health Effects: Severe gastrointestinal issues, nausea, vomiting, muscle weakness, cardiotoxicity, respiratory distress
Chemical Name: Emetine Hydrochloride
Concentration: ≥98% (as supplied for laboratory use)
Impurities: Trace levels may include related alkaloids or residual solvents depending on manufacturer
Molecular Weight: 545.55 g/mol
Chemical Family: Isoquinoline alkaloids
EC Number: 206-228-8
Inhalation: Remove casualty to fresh air, keep at rest, support breathing if necessary, seek immediate medical help
Ingestion: Rinse mouth thoroughly, never give liquid to an unconscious person, call poison center or physician at once
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water for at least 15 minutes, get medical attention
Eye Contact: Rinse eyes immediately with clean water for at least 15 minutes while keeping eyelids open, remove contact lenses if present and easy, urgent medical care needed
Most Important Symptoms: Nausea, vomiting, muscle weakness, arrhythmia, possible cardiac arrest; prompt attention required
Notes for Physicians: Treat symptoms, monitor cardiac and respiratory status, consider gastric lavage or activated charcoal only with secured airway
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, or foam
Unsuitable Extinguishing Media: Direct water jet may spread the material
Specific Hazards: Emits toxic fumes of hydrochloric acid, carbon oxides, nitrogen oxides under fire
Protective Equipment: Self-contained breathing apparatus, full protective gear
Precautions: Keep away from sources of ignition, move containers from fire zone if safe, cool unopened containers with water mist
Combustion Products: Hydrogen chloride, carbon monoxide, carbon dioxide, nitrogen oxides
Personal Precautions: Evacuate non-essential personnel, use personal protective equipment including gloves, protective clothing, respirator
Environmental Precautions: Prevent release to waterways, soil, and drains, use absorbent materials for containment
Methods for Cleaning Up: Minimize dust, collect with a vacuum equipped with HEPA filter or wet methods, place in closed containers for proper disposal
Decontamination: Wash spill site with soap and water after material pickup is complete
Safe Handling: Use in well-ventilated area with appropriate PPE, avoid inhalation, ingestion, and skin or eye exposure, do not eat or drink while working
Storage Conditions: Keep container tightly closed in cool, dry, and well-ventilated place, protect from direct sunlight and incompatible materials
Storage Temperature: Typically store at 2–8°C (refrigerated), away from incompatible substances such as oxidizing agents
Special Requirements: Label all containers, keep away from children and unauthorized persons, maintain inventory control
Occupational Exposure Limits: No specific regulatory limits established, minimize exposure as much as possible
Engineering Controls: Use fume hood, general room ventilation, safety shower, and eyewash stations
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat, respiratory protection if dust or aerosols generated
Hygiene Measures: Wash hands thoroughly after handling, change contaminated clothing, clean work surfaces
Appearance: White to pale yellow crystalline powder
Odor: Odorless or slight characteristic odor
pH: Slightly acidic (aqueous solution)
Boiling Point: Decomposes before boiling
Melting Point: 277–278°C (decomposes)
Solubility: Soluble in water, slightly soluble in ethanol
Density: Approximately 1.15 g/cm³
Vapor Pressure: Not applicable
Partition Coefficient (log Kow): Not readily available
Flammability: Not classified as flammable but may burn at high temperature
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Can react with strong oxidizing agents, acids, and bases
Possibility of Hazardous Reactions: No dangerous reactions known under normal use; avoid mixing with incompatible materials
Decomposition Products: Toxic fumes of hydrochloric acid, nitrogen oxides, carbon oxides on combustion or thermal decomposition
Conditions to Avoid: Excessive heat, moisture, direct light, incompatible substances
Acute Toxicity: Oral LD50 (rat): ~5–10 mg/kg; highly toxic by ingestion, inhalation, skin absorption
Chronic Effects: May cause cumulative heart and muscle toxicity, liver and kidney damage with prolonged exposure
Symptoms of Overexposure: Severe nausea, vomiting, diarrhea, hypotension, cardiac arrhythmias, convulsions, respiratory failure
Target Organs: Heart, liver, gastrointestinal tract, nervous system
Carcinogenicity: Not listed by IARC, NTP, or OSHA as carcinogen
Mutagenicity/Teratogenicity: No strong data, but handle with caution due to toxicity profile
Ecotoxicity: Very toxic to aquatic organisms, potential for long-term adverse effects in aquatic environments
Persistence and Degradability: Limited data, not expected to degrade rapidly in environment
Bioaccumulative Potential: May accumulate in aquatic organisms due to high toxicity
Mobility in Soil: Not highly volatile, but can leach if spilled on ground
Other Adverse Effects: Release to environment should be avoided due to ecosystem risk
Waste Disposal Methods: Treat as hazardous waste; use licensed chemical disposal contractors
Contaminated Packaging: Dispose of as chemical waste following local, state, and national regulations
Environmental Precautions: Do not discharge to drains, waterways, or soil
Recommended Controls: Incinerate in controlled facility equipped for toxic waste, ensure complete destruction of hazardous components
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Emetine Hydrochloride)
Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Transport Labels Required: Toxic, Marine Pollutant
Special Precautions: Keep container tightly sealed, prevent spills during transit, ensure documentation is complete
Land, Sea, Air Transport: Consistent with IATA, IMDG, and DOT requirements
TSCA Status: Not listed for unrestricted commercial use
DSL Status: Check Canadian DSL/NDSL for current status
U.S. Regulatory: Subject to OSHA Hazard Communication Standard, SARA Title III Sections 302/313 reporting may apply
EU Classification: Hazardous, requires CLP/GHS labeling and risk statements
Other Regulatory Info: Handle according to national and local safety, workplace, and environmental regulations where used
