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Product Name: Ectoine
Chemical Name: 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid
CAS Number: 96702-03-3
EC Number: 619-230-9
Recommended Use: Skin care formulations, pharmaceutical intermediate, research applications, biotechnology processes
Supplier Details: Consistent supplier address and emergency contact information should be linked to the facility and supporting documentation for traceability in case of exposure concerns or transportation incidents.
GHS Classification: Ectoine does not meet the criteria for classification as hazardous according to Regulation (EC) No. 1272/2008 (CLP), OSHA Hazard Communication Standard
Hazard Statements: No significant physical or health hazards have been observed under normal handling and use conditions. Dust may cause minor mechanical eye and respiratory tract irritation. Not expected to sensitize skin or respiratory system.
Signal Word: Non-hazardous
Pictograms: Not required
Precautionary Statements: Avoid breathing dust, practice normal industrial hygiene including hand washing after handling, ensure adequate ventilation in handling areas, avoid eye contact.
Chemical Name: Ectoine
Synonyms: (S)-2-Methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid, Ectoin
Chemical Formula: C6H10N2O2
Concentration: ≥98% pure
Impurities: Typical minor impurities include water (<2%), residual amino acids (<1%), no classified hazardous impurities present
Molecular Weight: 142.16 g/mol
Eye Contact: Rinse cautiously with clean water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and obtain medical attention if irritation persists.
Skin Contact: Wash with mild soap and water. Remove contaminated clothing, which can be laundered for reuse. Seek medical attention if skin irritation occurs or persists.
Inhalation: Move exposed person to fresh air and keep comfortable for breathing. Get medical advice if symptoms like coughing or irritation develop.
Ingestion: Rinse mouth with water. Seek medical advice in case of discomfort, persistent symptoms, or large ingestion.
Important Note: No delayed or immediate acute effects expected under normal conditions.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide (CO₂), foam, or water spray to extinguish. Use water spray to cool containers if exposed to fire.
Unsuitable Extinguishing Media: Avoid direct jet of water which can spread dust.
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and nitrogen oxides can form under fire conditions.
Special Protective Equipment for Fire-Fighters: Use self-contained breathing apparatus (SCBA) and suitable protective clothing to prevent skin and eye contact.
Advice for Fire-Fighters: Approach fire from upwind, prevent runoff from entering drains or water courses, and isolate area if safe to do so.
Personal Precautions: Wear appropriate protective equipment, including gloves and safety goggles. Avoid breathing dust. Evacuate unnecessary personnel from area.
Environmental Precautions: Prevent product from entering drains, surface water, or soil. Use containment methods to stop spread.
Methods for Clean-Up: Collect spilled powder with suitable tools (brush, shovel) and transfer to suitable labeled container for disposal or re-use. Use industrial vacuum if available to minimize dust formation. Wash the area with water after removal.
Reference to Other Sections: See Exposure Controls / Personal Protection and Disposal Considerations for more details.
Precautions for Safe Handling: Handle in well-ventilated area. Minimize dust generation and accumulation. Use safe material transfer practices to avoid release. Avoid contact with eyes and prolonged skin contact.
Conditions for Safe Storage: Keep in tightly sealed container in cool, dry, and well-ventilated space. Store away from incompatible substances such as oxidizers. Protect from moisture and direct sunlight. Maintain clear labelling and access control.
Specific Uses: Follow established protocols and good industrial hygiene standards for chemical handling within manufacturing, laboratory, or production environments.
Occupational Exposure Limits: No specific national or international exposure limits set for ectoine.
Engineering Controls: Apply local exhaust ventilation in dusty areas. Maintain good general ventilation wherever handling bulk product.
Personal Protective Equipment: Wear safety goggles for eye protection, nitrile or latex gloves for hand protection, and dust mask (P2 or N95) for respiratory protection when excessive dust is present.
Hygiene Measures: Wash hands thoroughly after handling. Remove contaminated clothing before entering eating areas. Do not eat, drink, or smoke while using the chemical.
Environmental Exposure Controls: Implement proper spill prevention/sediment retention to reduce environmental release.
Appearance: White crystalline powder
Odor: Odorless or almost odorless
pH (1% Solution in Water): 6.5-8.5
Melting Point: 280-282°C
Boiling Point: Decomposes before boiling
Solubility in Water: Easily soluble (>100 g/L at 20°C)
Solubility in Other Solvents: Slight solubility in ethanol, methanol; insoluble in ether
Density: Approx. 1.3 g/cm³
Particle Size: Variable, as supplied; typically ranges from fine powder to small crystals
Other Properties: Stable under normal temperature and pressure, non-volatile.
Chemical Stability: Stable under suggested storage and handling conditions.
Reactivity: Not known to react violently with water, air, or common laboratory chemicals.
Conditions to Avoid: Excessive heat, moisture, and direct sunlight.
Incompatible Materials: Strong oxidizing agents may cause reactions.
Hazardous Decomposition Products: Thermal decomposition can give rise to carbon monoxide, carbon dioxide, nitrogen oxides.
Polymerization: No dangerous polymerization expected.
Acute Toxicity: Oral LD50 (rat) > 2000 mg/kg (practically non-toxic). Not acutely hazardous by inhalation or skin contact based on available animal studies and known use cases.
Skin Corrosion/Irritation: Non-irritant to skin in typical use concentrations; mild temporary dryness possible with prolonged, repeated exposure.
Serious Eye Damage/Irritation: May cause mild mechanical irritation on direct contact with dust.
Respiratory Sensitization: Non-sensitizing based on currently available information.
Carcinogenicity/Mutagenicity/Reproductive Toxicity: No evidence of carcinogenic, mutagenic, or reproductive hazards reported for ectoine.
Other Effects: Not classified as hazardous by major regulatory bodies; no significant cumulative, target organ, or systemic toxicity observed at anticipated exposure levels.
Ecotoxicity: Tests have shown very low toxicity to aquatic life (EC50/LC50 values above 100 mg/L for Daphnia magna, algae, and fish). Limited risk for aquatic environments when reasonable containment practices observed.
Persistence and Degradability: Substantially biodegradable under both aerobic and anaerobic conditions. Soil and water microbes rapidly metabolize ectoine.
Bioaccumulation Potential: No bioaccumulation expected due to high water solubility and rapid biodegradation profile.
Mobility in Soil: Highly mobile in water; unlikely to bind to soil particles.
Other Adverse Effects: No known effects on terrestrial or aquatic ecosystems under normal conditions of use and accidental release contained with proper cleanup.
Waste Treatment Methods: Dispose of waste in accordance with local, regional, national, and international regulations. Collect in sealed containers for disposal by licensed waste contractor.
Additional Notes: Flush small residual amounts with water into drains connected to wastewater treatment plants. Avoid disposal where material could enter watercourses untreated.
Packaging Disposal: Empty containers and packaging can be recycled or disposed of as non-hazardous waste following thorough cleaning and removal of residual substance.
UN Number: Not classified as dangerous for transport.
Proper Shipping Name: Not regulated as hazardous material.
Transport Hazard Class: No special classification required.
Packing Group: No restriction for ground, air, or sea transport.
Special Precautions: Keep container tightly closed, protected from moisture, and stored upright in transport vehicles. Prevent breakage to avoid dust generation.
Environmental Hazards: Product does not pose significant environmental risk if shipped according to standard practices.
International Regulations: Ectoine does not appear on major lists of hazardous substances such as the US TSCA, European REACH Substances of Very High Concern, or the IARC list of carcinogens.
Label Elements: No mandatory hazard labelling required according to EU and US regulations.
Other Regulatory Notes: Ensure compliance with workplace safety, quality, and environmental management systems required for chemicals in industrial or laboratory use. National and local chemical safety laws may require record-keeping and supplier notification for quantities handled above certain thresholds.
Workplace Exposure Standards: No occupational exposure limits set in US, EU, or most other jurisdictions, reflecting low hazard profile.
