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Product Name: Econazole Nitrate
Chemical Name: 1-[2-(4-Chlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
CAS Number: 24169-02-6
Synonyms: Pevaryl, Spectrazole, Ecostatin
Recommended Use: Antifungal agent for topical formulations and research
Manufacturer: Contact information varies by brand and distributor
Emergency Phone Number: Provided by product supplier
GHS Classification: Acute toxicity (oral, category 4), Eye irritation (category 2A), Skin irritation (category 2), Specific target organ toxicity (single exposure, category 3)
Hazard Statements: Harmful if swallowed, causes skin and serious eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark symbol
Precautionary Statements: Avoid inhalation and contact with eyes or skin; wash hands thoroughly after handling; use only outdoors or in well-ventilated areas
Other Hazards: Powder or dust may form combustible mixture with air
Chemical Name: Econazole Nitrate
Percent: >98% purity, varies by manufacturer
Impurities/Other Ingredients: Trace solvents or processing aids
Molecular Formula: C18H15Cl3N2O•HNO3
Inhalation: Move affected person into fresh air, support breathing, seek medical help for persistent symptoms
Skin Contact: Remove contaminated clothing, rinse skin with soap and water, get medical attention for irritation
Eye Contact: Rinse cautiously with water for minimum 15 minutes, remove contact lenses if possible, continue rinsing, get immediate medical assistance
Ingestion: Do not induce vomiting, rinse mouth, drink water if conscious, seek prompt medical advice
Symptoms: Coughing, shortness of breath, redness or rash, eye watering or burning, stomach upset
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Extinguishing Media: High pressure water jet
Specific Hazards: May emit toxic fumes including hydrogen chloride, nitrogen oxides, carbon monoxide, and carbon dioxide
Protective Equipment: Wear self-contained breathing apparatus and protective gear
Special Precautions: Keep containers cool with water spray, avoid inhalation of combustion gases
Personal Precautions: Use personal protective equipment, avoid dust formation, ventilate area
Environmental Precautions: Prevent spills from entering drains or waterways
Cleanup Methods: Sweep or vacuum spillage, place in closed containers for disposal, clean area thoroughly after collection
Avoidance: Prevent dispersal of dust and accidental contact with skin or eyes
Handling: Use in well-ventilated spaces, avoid generating dust, prevent contact with eyes, skin, and clothing, wash hands after use
Storage: Keep container tightly closed in cool, dry, and well-ventilated place away from direct sunlight and incompatible substances
Incompatibles: Strong oxidizers, acids, bases
Other Precautions: Store away from food and beverages, prevent access by unauthorized personnel
Exposure Limits: No official occupational exposure limits set; handle as hazardous chemical
Engineering Controls: Work in chemical fume hood or well-ventilated area
Personal Protective Equipment: Nitrile or other chemical-resistant gloves, safety goggles or face shield, lab coat or protective clothing, approved respiratory protection for dust
Hygiene Measures: Wash hands and face after handling, do not eat/drink/smoke while working with the product
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not available
Melting Point: Approximately 162°C–165°C
Boiling Point: Decomposes before boiling
Solubility: Practically insoluble in water, soluble in alcohol and chloroform
pH Value: Not determined
Vapor Pressure: Very low (data not available)
Partition Coefficient (log Kow): About 2.4 (Econazole base)
Density: Approximately 1.4 g/cm³ (calculated)
Flash Point: Not relevant (non-flammable solid)
Explosion Limits: Not established for the product
Reactivity: Stable under normal storage and handling conditions
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: Does not undergo hazardous polymerization
Conditions to Avoid: Heat, flames, sources of ignition, moisture
Incompatible Materials: Strong oxidizers, strong acids and bases
Decomposition Products: Carbon oxides, nitrogen oxides, hydrogen chloride gas
Acute Toxicity: LD50 (oral, rat): Approximately 438 mg/kg
Skin Corrosion/Irritation: Causes irritation in animal models, may cause redness and irritation on contact
Serious Eye Damage/Irritation: Severe irritation confirmed in animal testing, avoid all eye contact
Respiratory Sensitization: May cause respiratory system irritation if inhaled
Skin Sensitization: Sensitization possible, especially with prolonged or repeated exposure
Carcinogenicity: No indication of carcinogenic effects in available studies
Mutagenicity: Negative in standard genotoxicity assays
Reproductive Toxicity: No significant hazard in animal studies
Target Organ Effects: Reported to affect gastrointestinal and respiratory systems with high exposures
Ecotoxicity: Hazardous to aquatic life, especially in higher concentrations, chronic aquatic toxicity data limited
Persistence and Degradability: Expected to degrade slowly in the environment
Bioaccumulation Potential: Moderate risk for bioaccumulation (log Kow value approximately 2.4)
Mobility in Soil: Low water solubility limits leaching; product may adhere to soil particles
Other Adverse Effects: No data on ozone depletion, global warming, or photochemical ozone creation potential
Disposal Methods: Collect in tightly sealed containers, send to authorized chemical waste disposal facility
Disposal of Packaging: Rinse and dispose as regulated hazardous waste, ensure containers are empty before disposal
Environmental Precautions: Avoid release into environment, do not flush into sewers or waterways
Regulatory Compliance: Disposal must align with local, regional, and national regulations
UN Number: Not classified as dangerous goods for transport
UN Proper Shipping Name: Econazole Nitrate, not hazardous for air, sea or land shipment in small amounts
Transport Hazard Class: Not regulated
Packing Group: Not designated
Environmental Hazards: Not a marine pollutant
Precautions: Transport in well-sealed containers, protect from heat and rough handling
International Inventories: Listed in some chemical inventories (check local law)
SDS Compliance: Prepared according to Globally Harmonized System (GHS) and OSHA Hazard Communication Standard
Labeling Requirements: Signal word “Warning”, hazard pictograms, precautionary statements
Other Regulations: Considered pharmaceutical product in finished form, subject to prescription-only status in many regions
Workplace Controls: Detailed under occupational safety agencies such as OSHA (US), HSE (UK), ECHA (EU)
Restrictions: Use restricted to trained personnel, typically in labs or pharmaceutical manufacturing
