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Product Name: Echinocandin B0
Synonyms: Caspofungin precursor, Semi-synthetic antifungal intermediate
CAS Number: 72716-60-6
Recommended Use: Active pharmaceutical ingredient intermediate, antifungal research applications
Supplier: [To be filled by end user’s organization]
Emergency Contact: Contact local emergency services or poison control for immediate guidance
GHS Classification: Acute Toxicity (Oral), Skin Irritation, Eye Irritation, May cause respiratory irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed; may cause irritation to eyes, skin, mucous membranes, and respiratory system
Precautionary Statements: Avoid breathing dust or vapors; wear protective gloves; wash hands thoroughly after handling; use only in a well-ventilated area
Hazard Pictograms: Exclamation mark, Health hazard
Chemical Identity: Echinocandin B0
Purity: ≥ 95%
Chemical Composition: C51H85N7O17
Impurities: Trace solvent residues, related echinocandin analogs (collectively < 1%)
Molecular Weight: 1076.25 g/mol
Inhalation: Remove person to fresh air; keep at rest in a comfortable position; seek medical attention if symptoms develop
Skin Contact: Wash with soap and plenty of water for at least 15 minutes; remove contaminated clothing; seek medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; seek medical advice if irritation occurs
Ingestion: Rinse mouth with water; do not induce vomiting; give water to dilute if the person is conscious; seek immediate medical attention
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Specific Hazards: May emit toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides during combustion
Protective Equipment: Self-contained breathing apparatus, full protective suit
Additional Recommendations: Move containers from fire area if possible; cool exposed containers with water spray; prevent runoff from entering drains or waterways
Personal Precautions: Evacuate area; avoid formation of dust; wear appropriate protective equipment including gloves, goggles, and dust mask
Environmental Precautions: Prevent further leakage or spillage; avoid discharge into drains, water courses, or soil
Methods for Cleanup: Sweep up and place in suitable, closed container for disposal; ventilate area and wash spill site after material pickup is complete
Safe Handling: Wear protective gloves, eye protection, and clothing; avoid inhalation and contact with skin or eyes; use only in well-ventilated surroundings
Storage Requirements: Store in a tightly closed container in a dry, cool, well-ventilated area; protect from moisture and direct sunlight; keep away from incompatible substances including oxidizing agents
Engineering Controls: Use chemical fume hood and effective ventilation to minimize airborne exposure
Personal Protective Equipment: Safety goggles, protective gloves, lab coat or coveralls; use a NIOSH-approved respirator for airborne dust or vapors
Hygiene Measures: Wash hands and face after handling; do not eat, drink, or smoke during use; keep work clothing separate from other laundry
Appearance: White to off-white powder
Odor: Odorless
pH (aqueous solution): Not applicable
Melting Point/Range: Decomposes above 200°C
Boiling Point: Not determined
Solubility: Slightly soluble in water and DMSO; insoluble in ethanol and chloroform
Vapor Pressure: Not available
Relative Density: Not determined
Partition Coefficient (n-octanol/water): Not available
Chemical Stability: Stable under recommended storage conditions
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition: Carbon oxides, nitrogen oxides if burned
Conditions to Avoid: Exposure to moisture, excessive heat, direct sunlight
Acute Toxicity: Data limited; expected to be harmful if swallowed or inhaled
Skin Sensitization: May cause allergic reactions in sensitive individuals
Eye Effects: Irritation possible upon exposure
Mutagenicity/Carcinogenicity: Studies lacking; no classification as carcinogenic
Target Organs: No long-term studies identified; potential impacts to liver and kidneys based on related compounds
Exposure Route: Dermal, inhalation, ingestion
Ecotoxicity: Data lacking; should be treated as potentially hazardous to aquatic life; avoid release to environment
Mobility in Soil: Poorly mobile due to limited solubility
Persistence and Degradability: Not readily biodegradable
Bioaccumulative Potential: Not established; precaution is best approach
Other Adverse Effects: Possible risk of groundwater contamination if not disposed as regulated
Waste Disposal Methods: Dispose of in accordance with local, regional, national, and international regulations; chemical incineration or approved waste disposal facility
Container Disposal: Triple rinse and manage the empty container as hazardous waste
Precautions: Do not flush into surface water or sanitary sewer system
Special Considerations: Consult environmental authority for specific guidance on waste handling
UN Number: Not assigned (research chemical, not regulated)
Transport Hazard Class: Not classified
Packing Group: Not classified
Labeling Requirements: Handle as non-hazardous but include chemical name and handling instructions
Special Transport Precautions: Protect from moisture and temperature extremes; secure containers to prevent breakage during transit
Inventory Status: Not listed under US TSCA, EU REACH, or other major chemical inventories (research use only)
Regulatory Classification: Echinocandin B0 is not specifically regulated, but general chemical safety and pharmaceutical intermediate laws apply
Workplace Requirements: Occupational exposure limits have not been established; default to local chemical handling regulations and safety standards
Other International Regulations: Handle according to Good Laboratory Practice guidelines, and report any accidental release or exposure per national legislation
