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Product Name: Dyclonine Hydrochloride
Chemical Name: 4-(Butylamino)-alpha-(2,4-xylyloxy)propiophenone hydrochloride
Synonyms: Dyclone HCl, Dyclonine HCl
Recommended Use: Topical anesthetic, pharmaceutical ingredient
CAS Number: 536-43-6
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Classification: Harmful if swallowed, causes serious eye irritation, may cause respiratory tract irritation
GHS Label Elements: Warning, exclamation mark symbol
Hazard Statements: Harmful to aquatic life, irritating to eyes, skin, and mucous membranes
Precautionary Statements: Wear gloves and eye protection, avoid inhalation, avoid release to the environment
Potential Health Effects: Short-term exposure causes numbness, burning sensation; long-term exposure could lead to CNS effects, headache, nausea
Chemical Identity: Dyclonine Hydrochloride
Concentration: Greater than 98% pure
Molecular Formula: C18H28ClNO2
Impurities: Trace organic solvents, water
Other Components: No additional hazardous substances present in concentrations >1%
Inhalation: Move to fresh air. If breathing difficulties occur, seek medical attention immediately.
Skin Contact: Remove contaminated clothing, rinse affected area with plenty of water and mild soap. Get medical advice if irritation remains.
Eye Contact: Rinse eyes cautiously with clean water for at least 15 minutes. Remove contact lenses if present and easy to do.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting unless directed by medical personnel. Call poison center or physician.
Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Unsuitable Extinguishing Media: High volume water jets may spread powder
Specific Hazards: May evolve hydrogen chloride gas or nitrogen oxides in a fire; powders may form explosive dust-air mixtures
Firefighter Protection: Wear self-contained breathing apparatus and full protective gear
Advice: Remove material from fire zone if safe; otherwise, cool containers with water spray
Personal Precautions: Avoid breathing dust, ensure adequate ventilation, use personal protective equipment
Environmental Precautions: Stop spill from entering drains, sewers, or natural waterways
Spill Cleanup Methods: Collect spill using shovel or other suitable equipment, avoid producing dust, place in appropriate chemical waste containers
Decontamination: Wash spill site with water and detergent after material pickup
Safe Handling: Use only outdoors or in well-ventilated areas, avoid contact with skin, eyes, and clothing
Hygiene Measures: Wash thoroughly with soap and water after handling, do not eat, drink, or smoke during handling
Storage Conditions: Keep container tightly closed in a dry, cool, well-ventilated place, protect from light, store away from strong acids and oxidizers
Other Recommendations: Ensure access to emergency eyewash station and safety shower
Engineering Controls: Use fume hood or equivalent ventilation system, minimize dust generation
Respiratory Protection: Use NIOSH-approved dust mask or respirator when exposure limits are exceeded
Eye Protection: Safety goggles or face shield
Hand Protection: Nitrile or butyl rubber gloves
Skin Protection: Long-sleeve lab coat or protective clothing
Work Hygiene: Do not reuse contaminated clothing, regularly check PPE for signs of damage
Physical State: Crystalline powder
Color: White or nearly white
Odor: Mild, aromatic
Melting Point: 179–183°C
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water and alcohol
pH (1% Solution): Approximately 5 - 7
Partition Coefficient (log Kow): Not specified
Vapor Pressure: Negligible
Density: 1.1–1.2 g/cm3
Flash Point: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactions if used as intended
Conditions to Avoid: Excess heat, direct sunlight, moisture, incompatible materials
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Hazardous Decomposition Products: Hydrogen chloride fumes, nitrogen oxides, carbon oxides when heated to decomposition
Acute Toxicity: Oral LD50 (rat): Approximately 500–800 mg/kg
Skin Corrosion/Irritation: Causes mild to moderate irritation
Serious Eye Damage/Irritation: Can cause severe eye irritation and transient damage
Respiratory Sensitization: Dust inhalation can irritate respiratory tract
Chronic Effects: Prolonged exposure may cause central nervous system depression, dizziness, confusion
Carcinogenicity: No data to suggest carcinogenic risk in humans
Mutagenicity and Reproductive Toxicity: Data insufficient for conclusive statement; handle with care to avoid unnecessary exposure
Aquatic Toxicity: Harmful to fish and other aquatic organisms
Persistence and Degradability: May persist in the environment if released in large quantities
Mobility in Soil: Moderately mobile; can leach into groundwater under certain conditions
Bioaccumulation Potential: Not expected to significantly bioaccumulate
Other Adverse Effects: Avoid introduction into natural water bodies due to risk for aquatic habitats
Waste Treatment Methods: Dispose of this material and its container at hazardous or special waste collection point
Unused Material: Incinerate following federal, state, and local regulations
Contaminated Packaging: Clean thoroughly before recycling or dispose of as hazardous waste
Environmental Precautions: Prevent release into sewers and waterways
Other Information: Comply with legislation regarding disposal of hazardous chemicals; contact local authorities for details
UN Number: Not classified as dangerous goods for transport
UN Proper Shipping Name: Dyclonine Hydrochloride
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions: Protect from physical damage, moisture, follow procedures for pharmaceutical chemicals
Environmental Hazards: Not regarded as environmentally hazardous for transport conditions
Labeling: Comply with national and international chemical safety and labeling guidelines
Safety, Health and Environmental Regulations: Subject to local workplace, chemical, and environmental safety rules
SARA Title III: Not listed as a hazardous substance in sections 302, 304, 313
OSHA: Not regulated as a hazardous chemical under OSHA Hazard Communication Standard
TSCA : Dyclonine and its salts are listed
REACH Status: Check for reporting requirements under REACH if handling in Europe
Other References: Consult national inventories for any restrictions or requirements
