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Product Name: Doxycycline Hyclate
Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate
Chemical Family: Tetracycline antibiotic
CAS Number: 24390-14-5
Manufacturer: Contact supplier for details
Recommended Use: Antimicrobial for bacterial infections in humans and animals
Emergency Contact: National Poison Control Center or local medical emergency provider
Hazard Classification: Eye damage/irritation (Category 2A), May cause allergic skin reaction (Category 1), Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, can trigger sensitization in skin, harmful if swallowed
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Wear protective gloves, avoid inhaling dust, wash thoroughly after handling, avoid contact with eyes or skin
Potential Health Effects: Irritation to eyes, skin, and respiratory tract, possible allergic reactions, long-term effects on liver and gastrointestinal system reported in some cases
Chemical Name: Doxycycline Hyclate
Common Name: Doxycycline
Concentration: 98–102% (main active ingredient)
CAS Number: 24390-14-5
Inactive Components: May include stabilizers, fillers, trace ethanol from manufacturing process
General Advice: Remove contaminated clothing and shoes
Eye Contact: Rinse cautiously with water for several minutes, lift eyelids to ensure thorough cleaning, seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing, seek medical advice if irritation develops
Inhalation: Move individual to fresh air, medical attention if breathing becomes difficult
Ingestion: Rinse mouth, seek immediate medical help, do not induce vomiting unless instructed by a health professional
Most Important Symptoms/Effects: Severe irritation, allergic reactions, nausea, vomiting, possible hepatic injury on long-term or accidental overdose
Notes to Physician: Treat symptomatically and supportively
Suitable Extinguishing Agents: Water spray, foam, dry chemical, carbon dioxide
Specific Hazards: Emits toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide under fire conditions
Firefighting Instructions: Wear self-contained breathing apparatus, use protective gear, avoid inhaling fumes
Unusual Fire/Explosion Hazards: Fine powder may form explosive mixture with air in rare cases
Protective Equipment: Full firefighting turn-out gear and self-contained breathing apparatus for significant fire
Personal Precautions: Ventilate area, use dust mask or respirator, avoid dust formation
Environmental Precautions: Prevent further leakage if safe, avoid discharge into sewers and waterways
Cleanup Methods: Sweep up and place in approved containers for disposal, wash area with plenty of water, avoid generating airborne dust
Disposal: Collect spilled material in tightly sealed containers, dispose of in accordance with regional and national regulations
Safe Handling Advice: Use in well-ventilated areas, minimize dust generation, avoid contact with skin, eyes, and clothing
Technical Measures: Use local exhaust ventilation, have eyewash stations and showers readily available in the work area
Storage Conditions: Store in tightly-closed containers away from light, moisture, and incompatible substances
Temperature Requirements: Keep at controlled room temperature, protect from excessive heat
Storage Compatibility: Keep separate from strong acids, strong oxidizers, and reducing agents
Engineering Controls: Use mechanical ventilation, fume hood for weighing or transfer operations, use with adequate exhaust
Personal Protective Equipment: Chemical-resistant gloves, safety glasses with side shields or goggles, lab coat
Respiratory Protection: Dust mask or approved respirator when handling powders
Hygiene Measures: Wash hands after handling, do not eat or drink in work area, avoid touching face during material handling
Appearance: Yellow to lime green crystalline powder
Odor: Odorless or faint medicinal smell
pH: Typically 2.0–3.0 (1% aqueous solution)
Melting Point: Decomposes before melting
Solubility: Soluble in water, ethanol to a limited degree
Molecular Formula: C22H24N2O8·HCl·½C2H6O·½H2O
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not determined
Density: Around 1.5 g/cm³
Partition coefficient (n-octanol/water): Not available
Chemical Stability: Stable under normal conditions, sensitive to heat and light
Reactivity: May react with strong acids, strong oxidizers, and reducing agents
Hazardous Reactions: May decompose on exposure to strong heat, forming hazardous gases
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Acute Toxicity: Signs include nausea, vomiting, gastrointestinal distress, dermal irritation
Chronic Toxicity: Long-term occupational exposure may affect liver or cause allergic responses
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Skin Sensitization: Documented cases of allergic contact dermatitis
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Reproductive Effects: May be harmful to fetus, risk acknowledged in pregnancy and lactation
Symptoms: Headache, rash, skin photosensitivity, gastrointestinal discomfort
Ecotoxicity: Harmful to aquatic life with long lasting effects
Biodegradability: Low to moderate, persistence in the environment possible
Bioaccumulation Potential: Unlikely to bioaccumulate significantly
Mobility in Soil: May migrate to groundwater in significant quantities under favorable conditions
Other Adverse Effects: Antibiotic may promote microbial resistance in environmental settings
Waste Disposal Methods: Do not discharge into drains or waterways, place in tightly sealed, labeled containers
Disposal of Contaminated Packaging: Rinse thoroughly or dispose as hazardous waste
Regulatory Requirements: Follow local, state, and federal environmental and hazardous waste regulations
Precautions: Personnel handling waste should wear protective gear, prevent environmental contamination
UN Number: Not regulated under major international transport codes
Packaging Requirements: Sealed, sturdy, leak-proof packaging
Transport Hazard Class: Not classified as dangerous goods
Special Transport Precautions: Avoid excessive vibration, high temperatures, direct sunlight; keep dry
Proper Shipping Name: Doxycycline Hyclate, non-hazardous for transport
OSHA: Not regulated as a specific hazardous chemical
EPA: Considered a pharmaceutical waste; certain disposal restrictions apply
TSCA: Doxycycline Hyclate appears on inventory
EU: Not classified as a dangerous substance under current directives
WHMIS (Canada): Caution, may cause sensitization; not otherwise specified
Other Regulations: Always reference and comply with latest national, state, and local legislation, as drug and substance regulations change
