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Product Name: Doramectin
Chemical Family: Avermectin
Synonyms: Dectomax, N-{(4''S)-5-O-Demethyl-25-de(1-methylpropyl)-25-(1,3-dihydroxypropan-2-yl)-22,23-dihydro-5,6,6a,11,13,23-hexahydro-14,16,20,22,24-pentaoxoavermectin}
CAS Number: 117704-25-3
Intended Use: Veterinary antiparasitic agent
Manufacturer Details: Provided by supplier and distributor on product packaging and technical sheets
Emergency Contact: Refer to local emergency number associated with workplace requirements and chemical handling
GHS Classification: Acute Toxicity (Oral) Category 4, Acute Toxicity (Inhalation) Category 4, Eye Irritation Category 2
Warning Symbols: Exclamation Mark (Harmful), Environmental Hazard
Hazard Statements: Harmful if swallowed, causes eye irritation, toxic to aquatic life with long-lasting effects
Precautionary Statements: Avoid release to environment, wear protective gloves and eye protection, seek medical advice if inhaled or swallowed
Possible Effects of Exposure: Headache, nausea, dizziness, mild skin and eye irritation, severe toxicity after significant oral intake, possible neurotoxicity at high doses in mammals
Doramectin: Concentration ranges 0.1% to 10% depending on formulation
Inert Constituents: Polyethylene glycol, propylene glycol, alcohols, stabilizers, buffers found in solution carriers; trace impurities from synthesis
Formulation Type: Generally found in injectable or topical solutions along with other medicinal or inert pharmaceutical excipients
Inhalation: Remove from exposure site; seek fresh air and medical attention if symptoms persist; monitor for respiratory distress
Skin Contact: Wash affected area thoroughly with soap and water; remove contaminated clothing; seek medical attention with irritation
Eye Contact: Rinse cautiously with water for 15 minutes; remove contact lenses if easy to do; do not rub eyes; get medical help
Ingestion: Rinse mouth with water; do not induce vomiting; drink a small quantity of water if conscious; call poison center or doctor
Most Important Symptoms: Gastrointestinal upset, lethargy, confusion, mild or severe irritant effects depending on exposure type
General Advice: Provide product label, MSDS, or description to attending medical personnel
Suitable Extinguishing Media: Foam, dry chemical, carbon dioxide, water spray for large fires
Unsuitable Extinguishing Media: Direct high-pressure water which can spread contamination
Fire Hazards: May produce fumes of carbon monoxide, nitrogen oxides, other hazardous decomposition products
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, chemical-resistant suit
Special Procedures: Approach upwind, isolate hazard area, cool containers with water spray if safe, prevent runoff into drains or watercourses
Personal Precautions: Use chemical-resistant gloves, goggles, suitable respiratory protection in confined areas
Environmental Precautions: Avoid discharges into soil, water systems, sewage; alert relevant authorities
Clean-up Methods: Absorb spill with inert material (sand, earth); collect in sealable containers for disposal; ventilate area
Decontamination: Wash surfaces with water and detergent; prevent further contamination
Reference to Other Sections: Consult fire response and exposure protection guidelines
Handling: Ensure all containers remain tightly closed during use; avoid breathing vapors; avoid eye and skin contact; do not eat, drink or smoke during handling
Technical Measures: Use in a well-ventilated area; avoid formation of aerosols; maintain adequate local exhaust
Storage Conditions: Store away from sunlight, incompatible substances, food or animal feed; temperature recommended between 2°C and 30°C
Packaging Materials: Use original manufacturer container or compatible chemical-resistant packaging
Exposure Limits: No occupational exposure limits set by OSHA or ACGIH; minimize exposure through engineering controls
Engineering Controls: Use fume hoods, exhaust ventilation at points of emission, adequate general ventilation
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile recommended), safety goggles, lab coat, suitable face shield for splash risk
Respiratory Protection: NIOSH-approved respirator if dust, mist or vapor may be airborne
Hygiene Measures: Wash thoroughly after handling; do not eat, drink, or smoke during work
Appearance: Viscous, colorless to slightly yellow liquid in formulated products; crystalline solid as pure compound
Odor: Faint, phenolic or alcoholic
pH: Not applicable to pure material; typical formulated solution ranges pH 4-7
Boiling Point/Range: Not determined (decomposes before boiling)
Melting Point: 162-164°C (pure)
Solubility: Moderately soluble in organic solvents, limited solubility in water
Density: 1.2-1.3 g/cm³ (approximate for formulations)
Vapor Pressure: Extremely low, negligible at ambient temperature
Partition Coefficient (log Kow): Above 4 (lipophilic)
Stability: Stable under recommended storage conditions; sensitive to strong light and oxidants
Chemical Stability: Remains stable under typical ambient conditions if protected from light and heat
Reactivity: No dangerous reactions under normal use
Hazardous Reactions: Strong oxidizing agents may trigger dangerous decomposition
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, possibly toxic fumes
Incompatible Materials: Strong acids, bases, oxidizers
Acute Toxicity: LD50 (oral, rat): 2-3 mg/kg; LD50 (dermal, rat): >2000 mg/kg
Chronic Exposure: Repeat exposure may affect nervous system; depressant effects observed in high-dose animal studies
Skin and Eye Contact: Mild to moderate irritant, symptoms improve with removal
Sensitization: Not a known skin sensitizer; rare allergic responses
Mutagenicity: No clear evidence of genotoxic effect
Carcinogenicity: Not classified as carcinogen under IARC, NTP or OSHA
Reproductive/Developmental Effects: No remarkable teratogenicity in animal tests within therapeutic dose, risk rises at higher exposure
Aquatic Toxicity: Highly toxic to fish, crustaceans, daphnids with LC50 under 1 μg/L
Environmental Fate: Lipophilic, binds strongly to soil, persistent in sediment; breaks down slowly under natural light
Degradation: Limited biodegradation in water; risk of bioaccumulation
Ecotoxicological Impacts: Major hazard for aquatic and sediment-dwelling invertebrates; not safe for untreated runoff
Persistence: Semi-persistent in environment, especially aquatic habitats; should not enter sewers, surface water, or groundwater systems
Waste Disposal Methods: Collect product residues and contaminated materials; dispose through licensed chemical waste contractor
Avoid: Draining to surface water, pasture land, public water systems
Container Disposal: Triple rinse then puncture containers, deliver to approved municipal collection or hazardous waste facility
Legal Framework: Follow all applicable local, state, federal, and national hazardous waste regulations
UN Number: 3077
Transport Name: Environmentally hazardous substance, solid, n.o.s (Doramectin)
Transport Class: 9 (Miscellaneous dangerous substances)
Packing Group: III (minor hazard)
Environmental Risks: Marine pollutant, keep separate from food and feedstuffs during transport
Transport Precautions: Secure packaging, label as hazardous; notify carrier of nature of contents
Regulatory Agencies: IMDG, IATA, ADR compliance required for international transport
OSHA Status: Not specifically regulated under OSHA hazardous chemical standards; recommended precautions according to general industry safety
EPA Registration: Registered as veterinary product with strict disposal and runoff guidelines
TSCA/DSL: Not listed for general industrial use
EU Classification: N (Dangerous for Environment), Xn (Harmful)
Risk Phrases: R22 (harmful if swallowed), R50/53 (very toxic to aquatic organisms, may cause long-term effects)
SARA/California Proposition 65: Not listed as carcinogen or reproductive toxicant
Other Regulations: Packaging, labeling, and reporting requirements found in relevant animal health, chemical transportation and workplace safety standards by FDA, EMA, and comparable authorities
