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Product Name: Dodecyltrichlorosilane
Chemical Formula: C12H25Cl3Si
Synonyms: Trichlorododecylsilane; Dodecyltrichlorosilane, 97%
Manufacturer: Provided by specialty chemical suppliers, typical industrial sources
Recommended Use: Used in the surface treatment of glass and silica-based materials, coatings, and laboratory research
Emergency Phone Number: Refer to supplier contact; in many regions, local Poison Control Center or emergency response service applies
CAS Number: 4484-72-4
GHS Classification: Corrosive to metals, Skin corrosion/irritation, Serious eye damage, Acute toxicity - oral and inhalation
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage. Harmful if swallowed, inhaled, or absorbed through skin. Reacts violently with water. Causes respiratory tract irritation.
Precautionary Statements: Wear protective gloves, eye/face protection, and protective clothing. Avoid breathing dust, vapor, or mist. Use only outdoors or in well-ventilated area. Wash thoroughly after handling.
Pictograms: Corrosive, Health Hazard, Exclamation Mark
Potential Health Effects: Contact leads to burns on skin, eyes, throat, and lungs; inhalation develops coughing or pulmonary edema in severe cases. May affect central nervous system with high exposure.
Chemical Name: Dodecyltrichlorosilane
Concentration: ≥97%
CAS Number: 4484-72-4
Impurities: Typically contains trace amounts of related organosilane species and residual solvents from synthesis, but primarily presented in pure commercial form.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting eyelids. Call a physician without any delay.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Apply burn ointment if available. Get medical attention promptly.
Inhalation: Move individual to fresh air. If breathing becomes difficult, qualified personnel should give oxygen. Seek medical help.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly. Give water if the person is conscious. Get immediate medical care.
Notes for Physician: Treat as corrosive chemical exposure. Watch for delayed pulmonary edema, chemical burns. Provide symptomatic and supportive care.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide (CO2), or alcohol-resistant foam. Do not use water as product reacts to form corrosive hydrogen chloride and flammable gases.
Specific Hazards: Releases toxic and corrosive fumes such as hydrogen chloride, silicon oxides, and possibly flammable dodecane byproducts on thermal decomposition.
Fire-Fighter Protection: Wear full protective gear, including self-contained breathing apparatus. Evacuate area and fight fire from safe distance. Maintain upwind direction.
Thermal Hazards: Containers may rupture or explode in fire due to heat and pressure buildup. Prevent water from coming into contact with material.
Personal Precautions: Evacuate unprotected personnel. Wear acid-resistant gloves, chemical splash goggles, full-body protection, and suitable respirator.
Environmental Precautions: Avoid runoff into drains, surface water, or groundwater. Notify authorities if large spillage could threaten the environment.
Methods for Containment: Contain spill with dikes. Do not allow water to contact spilled material.
Methods for Cleanup: Absorb with dry sand, earth, or non-combustible absorbent. Scoop into appropriate, corrosion-proof labeled containers for disposal. Ventilate area and wash spill site after material pickup.
Handling: Use only with adequate ventilation. Prevent skin and eye contact. Open containers carefully. Use proper tools to handle product. Manage potential vapors or mists with fume hoods or local exhaust. Do not breathe vapor or mist.
Hygiene Measures: Wash hands thoroughly after handling. Do not eat, drink, or smoke when working with chemical. Remove contaminated clothing.
Storage: Store in cool, dry, well-ventilated areas. Keep container tightly closed. Avoid moisture and water ingress. Use corrosion-resistant containers. Segregate from incompatible materials, especially oxidizers and bases.
Engineering Controls: Provide local exhaust ventilation and/or general dilution ventilation to limit vapor and mist exposure. Emergency eyewash and safety shower stations required.
Respiratory Protection: Use NIOSH- or EN-approved respirator suitable for acidic gases if vapor concentration increases.
Skin Protection: Wear acid-resistant gloves and chemical-resistant clothing.
Eye Protection: Wear safety goggles and face shield.
Occupational Exposure Limits: There are no definitive ACGIH, OSHA, or EU workplace exposure limits for dodecyltrichlorosilane. Control exposure as for strong acid vapors, maintaining airborne concentrations as low as possible.
Other Protection: Work in approved chemical fume hood; avoid direct contact.
Appearance: Clear to pale yellow liquid
Odor: Pungent, sharp, irritating (similar to hydrochloric acid and alkyl silanes)
Melting Point: −5 °C to 0 °C (estimates may vary by purity and actual source)
Boiling Point: 315–320 °C
Flash Point: 156 °C (closed cup)
Flammability: Combustible liquid
Vapor Pressure: Very low at room temperature
Solubility: Reacts vigorously with water
Density: Approximately 0.95–1.0 g/cm3 at 20 °C
pH: Not applicable (hydrolysis product is strongly acidic)
Partition Coefficient: Not readily available; hydrophobic; expected to partition into organic phase.
Chemical Stability: Stable in moisture-free, tightly sealed containers under recommended storage conditions. Decomposes on contact with water.
Incompatible Materials: Water, moisture, alcohols, strong oxidizers, acids, and bases.
Hazardous Decomposition Products: Hydrogen chloride gas, silicon oxides, dodecane, and other organosilicon compounds.
Polymerization: Does not undergo hazardous polymerization, but uncontrolled reactions with water produce heat and gases.
Acute Toxicity: Harmful by inhalation, ingestion, or skin absorption. Produces severe burns on contact.
Skin Corrosion/Irritation: Severe irritant and can cause deep tissue burns.
Eye Damage/Irritation: Causes irreversible eye damage, risk of blindness.
Inhalation Risk: Irritation to mucous membranes, coughing, shortness of breath, potential for chemical pneumonitis.
Chronic Effects: Repeated exposure may cause dermatitis, respiratory issues.
Carcinogenicity: Not classified as carcinogen by IARC, NTP or OSHA.
Other Risks: No substantial evidence for mutagenicity or reproductive toxicity, though hydrolysis byproducts should be considered for their own hazards.
Toxicity: Harmful to aquatic life due to release of hydrochloric acid and hydrophobic organic compounds. Silane hydrolysis forms persistent byproducts.
Persistence and Degradability: Degrades in the presence of water into silicic acid derivatives and dodecane. Hydrolysis is rapid in moist environments.
Bioaccumulation Potential: Bioaccumulation is expected to be low due to hydrolysis, but long-chain hydrocarbon byproducts could persist.
Mobility in Soil: Product binds to soil particles and reacts with water quickly, minimizing migration but risking local hotspots for ecotoxicity.
Other Effects: Avoid any release to water sources. Precise data on long-term ecological effects remains limited.
Waste Disposal: Treat as hazardous waste under local, regional, and national regulations. Incinerate in a chemical incinerator equipped with afterburner and scrubber, if allowed.
Container Disposal: Rinse thoroughly with compatible solvent before discarding containers. Do not introduce any rinsate to sewer. Follow regulatory requirements.
Precautions: Never dispose with household waste. Do not pour to drains, watercourses, or the environment.
Advice: Seek professional hazardous waste handler for collection and treatment.
UN Number: UN 2987
Proper Shipping Name: Trichlorosilane, organosilicon compound
Hazard Class: 8 (Corrosive)
Packing Group: II
Label Required: Corrosive, Environmental Hazard
Transport Precautions: Ship in tightly sealed, corrosion-resistant containers. Segregate from incompatible chemicals. Protect from moisture.
Special Transport Hazards: Be alert for leaks and fumes during transport or storage; notify local authorities in case of major spill.
OSHA: Classified as hazardous chemical under OSHA Hazard Communication Standard.
TSCA Status: Listed in the TSCA Chemical Inventory in the United States.
REACH Regulation (EU): Pre-registered, may require additional data for full compliance.
Inventory Listings: Present in major international chemical inventories, including Canada (DSL/NDSL), Japan (ENCS), and Australia (AICS).
Other Regulations: Subject to workplace, environmental, and transport safety regulations. Follow all federal, state, and local laws regarding storage, handling, and disposal.
Risk Phrases: Contains corrosive material; specialist advice may be needed before using the product.
