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Product Name: Docetaxel Intermediate
Chemical Formula: C43H53NO14
CAS Number: 114977-28-5
Synonyms: Taxotere Intermediate, Docetaxel Precursor
Manufacturer: Details available from supplier
Use: Pharmaceutical synthesis
Emergency Contact: Refer to the company safety coordinator
GHS Classification: Acute toxicity (oral, dermal, inhalation), Eye irritant, Skin sensitizer
Signal Word: Danger
Hazard Statements: Causes serious eye irritation, harmful if swallowed or inhaled, suspected of causing genetic defects, may damage fertility or the unborn child
Pictogram(s): Skull and crossbones, Health hazard
Precautionary Statements: Avoid breathing dust or vapors, wear protective gloves and eye protection, wash hands thoroughly after handling, do not eat, drink, or smoke during use
Chemical Identity: Docetaxel Intermediate
Purity: Over 98%
Impurities: Related synthetic intermediates (below 2%)
Ingredient Disclosure: None of the impurities are, to the current knowledge, classified as hazardous at relevant concentrations
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lift eyelids occasionally, remove contact lenses if present and easy to do, seek medical attention
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, get medical advice if symptoms develop
Inhalation: Move the person to fresh air, keep at rest in a position comfortable for breathing, obtain medical attention if any symptoms occur
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, seek immediate medical advice
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Hazards from Combustion Products: Emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, and possibly other irritating or toxic gases
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Advice for Responders: Move containers from fire area if possible without risk, stay upwind, prevent run-off from entering drains
Personal Precautions: Wear protective gloves, safety goggles, and appropriate protective clothing
Environmental Precautions: Prevent entry into drains, soil, or waterways
Cleanup Methods: Absorb spill with inert material such as sand, place in a labeled container for disposal, ventilate area, clean surface thoroughly after material removal
Special Procedures: Avoid dust generation, wash spill site after material pickup is complete
Handling: Use in a well-ventilated area, avoid contact with eyes, skin, and clothing, avoid breathing dust, wash hands before eating or drinking
Storage: Store in a tightly closed container, keep away from incompatible substances such as acids, bases, and oxidizing agents, keep in a dry, cool, well-ventilated place, protect from light
Occupational Exposure Limits: No specific limits established, take precautionary measures based on exposure control banding
Engineering Controls: Use chemical fume hood or local exhaust ventilation to limit airborne exposure
Personal Protection: Protective gloves (nitrile, neoprene), safety goggles, lab coat, respiratory protection if ventilation is inadequate
Hygiene Measures: Remove contaminated clothing and wash before reuse, wash hands thoroughly after handling
Appearance: White to off-white powder
Odor: Odorless
Melting Point: Not established specifically for intermediate; reference full Docetaxel above 170°C
Boiling Point: Not available
Solubility: Insoluble in water, soluble in organic solvents (methanol, dichloromethane)
pH: Not applicable
Vapor Pressure: Negligible at room temperature
Partition Coefficient: Not determined
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: No hazardous polymerization expected
Conditions to Avoid: Exposure to moisture, excessive heat, incompatible materials
Incompatible Materials: Oxidizing agents, strong acids or bases
Decomposition Products: Carbon oxides, nitrogen oxides, and potentially toxic fumes under fire conditions
Acute Toxicity: Harmful if swallowed or inhaled, may cause respiratory and gastrointestinal irritation
Skin Corrosion/Irritation: Causes mild to moderate irritation
Serious Eye Damage/Eye Irritation: Causes eye irritation
Respiratory Sensitization: Dust inhalation can provoke sensitization
Carcinogenicity: No conclusive data for the intermediate; Docetaxel itself is not listed as a carcinogen by NTP, IARC, or OSHA
Germ Cell Mutagenicity: Suspected based on parent compound data
Reproductive Toxicity: Can impair fertility, based on data from Docetaxel
Information on Possible Routes of Exposure: Inhalation, skin, eye, ingestion; symptoms include irritation, drowsiness, nausea
Toxicity: Toxic to aquatic life, based on data for structurally similar compounds
Persistence and Degradability: Not readily biodegradable, may persist in the environment
Bioaccumulative Potential: Low potential for bioaccumulation suggested
Mobility in Soil: Limited mobility expected
Other Adverse Effects: Avoid environmental release due to potential long-term effects
Waste Treatment Methods: Dispose of in compliance with local, regional, and national regulations, incineration in a chemical incinerator with afterburner and scrubber recommended
Contaminated Packaging: Dispose of as hazardous waste, thoroughly clean before recycling or disposal
Precautions: Do not release untreated waste into the environment
UN Number: Not classified as a dangerous good for transport under current regulations
Proper Shipping Name: Chemical, Non-Hazardous (for Docetaxel Intermediates)
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: May be hazardous to aquatic environments, avoid accidental spills during handling and transport
Safety, Health and Environmental Regulations: Product not specifically regulated under U.S. TSCA, EU REACH or other global chemical inventories due to its status as an intermediate
Label Requirements: Follow occupational safety and health guidelines for pharmaceutical chemicals
Chemical Safety Assessment: Not conducted on intermediates; use best industrial hygiene practices
Other Applicable Regulations: Observe all applicable local and international rules regarding pharmaceutical chemical handling, worker protection, and environmental discharge
