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Product Name: Maytansinoid DM4
Chemical Name: N2'-Deacetyl-N2'-(4-mercapto-1-methybutyl)-maytansine
CAS Number: 150838-09-6
Molecular Formula: C44H62ClN4O10S
Molecular Weight: 857.51 g/mol
Synonyms: DM4, Mertansine
Product Use: Research and pharmaceutical intermediate, antibody-drug conjugate payload
Manufacturer: [Manufacturer Information]
Contact Details: [Contact Details for Manufacturer or Supplier]
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Hazard Classification: Acute Toxicity (Oral, Dermal, Inhalation) – Category 2; Germ Cell Mutagenicity – Category 2; Carcinogenicity – Category 2; Reproductive Toxicity – Category 1B; Specific Target Organ Toxicity – Repeated Exposure – Category 2
Signal Word: Danger
Hazard Statements: Fatal if inhaled, absorbed through skin, or swallowed; May cause cancer and genetic defects; May impair fertility or harm the unborn child; May cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid contact with skin and eyes, avoid breathing dust or vapors, use only with adequate ventilation, do not eat, drink or smoke during use, wash thoroughly after handling
Pictograms: Skull and Crossbones, Health Hazard, Exclamation Mark
Chemical Name: Maytansinoid DM4
Concentration: ≥98%
CAS Number: 150838-09-6
Impurities: Minor related substances below 2%; no known significant additives
Additives: None
Stabilizers: None required under recommended conditions of storage
General Measures: Seek medical attention right away for any signs of exposure
Inhalation: Move person to fresh air, keep individual warm, artificial respiration if breathing stops, immediate medical attention required
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and soap for at least 15 minutes, medical attention needed for exposure or doubt
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, hold eyelids open, seek ophthalmological evaluation
Ingestion: Rinse mouth with water, do not induce vomiting, do not give anything by mouth to unconscious person, seek urgent medical help
Indication of Immediate Medical Attention Needed: Any exposure is considered potentially serious, due to potent cytotoxic mechanism
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray
Unsuitable Extinguishing Media: Avoid direct water jet
Special Hazards: Thermal decomposition may produce hazardous gases including nitrogen oxides, sulfur oxides, hydrochloric acid, carbon monoxide
Protective Equipment and Precautions: Use self-contained breathing apparatus, full protective suit, chemical-resistant gloves and boots
Fire & Explosion Hazards: Not highly flammable, but potentially hazardous residue may remain
Firefighting Instructions: Prevent run-off from entering drains, contain firefighting water for later disposal
Personal Precautions: Use full protective clothing, including respiratory protection, chemical goggles, and gloves
Environmental Precautions: Prevent spill from entering drains, soil, surface water or groundwater
Containment: Avoid dust formation, sweep up material using methods minimizing dust, soak up with inert absorbent (vermiculite, sand), place in a tightly closed container for disposal
Decontamination: Clean affected area with detergent and excess water, collect waste in suitable containers
Reporting: Notify authorities if large release occurs or if exposure affects environment or public health
Handling: Use containment systems and engineering controls, minimize aerosol generation, wear suitable PPE (gloves, lab coat, goggles)
General Hygiene: Prohibit eating, drinking, and smoking in work area; wash hands and face before breaks and at end of workday
Storage Conditions: Store at -20°C, protected from light and moisture, in tightly closed, labeled containers
Incompatibilities: Strong oxidizers, acids, alkalis
Storage Area Requirements: Secure, ventilated, restricted access to authorized personnel
Other Recommendations: Regularly check containers for wear, label all containers clearly, maintain inventory logs
Occupational Exposure Limits: No established limits; minimize exposure by following best practices
Engineering Controls: Work in approved fume hood, use local exhaust ventilation
Respiratory Protection: Wear NIOSH-approved respirator in absence of adequate ventilation or if dust generated
Eye Protection: Use safety goggles or face shield
Skin and Body Protection: Chemical-resistant gloves (nitrile or neoprene), lab coat or protective gown, closed shoes
Environmental Controls: Use spill trays, minimize waste; dispose of contaminated material as hazardous waste
Other Protective Measures: Have safety shower and eyewash station close by, maintain strict access controls
Physical State: Solid
Form: Crystalline or powder
Color: White to off-white
Odor: Odorless
Melting Point: 220–230°C (decomposition)
Boiling Point: Not applicable (decomposes)
Flash Point: Not determined
Solubility: Soluble in DMSO, methanol; practically insoluble in water
pH: Not applicable (insoluble in water)
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log P): Not available
Other Properties: Stable under recommended storage, may degrade in presence of strong acids/bases or light
Chemical Stability: Stable under specified storage and handling conditions (dry, cool, protected from light)
Reaction Risk: Incompatible with strong oxidizing or reducing agents, acids, bases
Conditions to Avoid: Heat, moisture, direct sunlight, physical shock
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride, sulfur compounds under fire or thermal decomposition
Polymerization: No data on hazardous polymerization
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity: Extremely toxic at microgram doses; LD50 (oral, rodent): 0.3–1.0 mg/kg
Chronic Toxicity: Possible carcinogen, mutagen, reproductive toxin
Symptoms of Overexposure: Nausea, headache, vomiting, bone marrow suppression, neuropathy, teratogenic effects, organ damage
Sensitization: No established sensitization record in humans, but risk exists
Additional Health Effects: Hematopoietic, hepatic, renal, nervous system impairment possible with repeated exposure
Other Information: Potent microtubule inhibitor, cytoxic mechanism; use strict containment and exposure controls
Aquatic Toxicity: Highly toxic to aquatic life due to potent biological activity
Persistence and Degradability: Not readily biodegradable, environmental half-life unknown
Bioaccumulation Potential: Data unavailable, assume potential for bioaccumulation due to lipophilicity
Mobility in Soil: Not soluble in water, low mobility anticipated
Other Adverse Effects: May disrupt aquatic and terrestrial organisms at low concentrations; do not release to the environment
Recommendations: Prevent entry into sewage, waterways, or soil; collect and dispose of all waste as hazardous
Waste Treatment Methods: Dispose of product, solution, and contaminated materials as hazardous waste via licensed contractor
Product Disposal: Incinerate in approved facility; do not landfill or pour into drains
Packaging Disposal: Decontaminate or triple rinse and dispose as hazardous material
Contaminated PPE: Treat as clinical cytotoxic waste and incinerate in designated containers
Precautions: Label all material clearly, follow local, regional, and national regulations for cytotoxic agents
UN Number: Not assigned for this substance
UN Proper Shipping Name: Cytotoxic compound, n.o.s.
Transport Hazard Class: Class 6.1 (toxic substances), if regulated
Packing Group: II or III, subject to jurisdiction
Environmental Hazards: Strongly advised as marine pollutant
Special Transport Precautions: Secure secondary containment, restrict access, accompanied by documentation
Transport Labels: Toxic substance, keep away from food and feedstuffs
TSCA Status: Not listed for commercial distribution in the U.S.
OSHA Hazard: Cytotoxic, acute toxin, reproductive hazard
IARC Classification: Not classified, but related compounds are Group 2A/B (possible/probable carcinogen)
GHS: Complies with classification as acute, chronic toxic, carcinogenic, reproductive toxin
Other International Regulations: Subject to strict handling, licensing, and waste rules in the EU, Canada, and Asia
Workplace Labelling: Label containers "Potent Cytotoxic – For Research Use Only"
Other Requirements: Training for personnel, annual review of exposure controls, keep records of use and disposal
