© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Diphenhydramine Hydrochloride
Chemical Name: 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride
CAS Number: 147-24-0
Recommended Use: Antihistamine for the relief of allergy symptoms
Manufacturer Information: Available from leading chemical and pharmaceutical suppliers
Synonyms: Benadryl Hydrochloride, DPH HCl
Emergency Phone: Chemtrec +1-800-424-9300 (for spills and emergencies)
GHS Classification: Acute Toxicity—Oral, Category 4; Eye Irritation, Category 2A; Specific Target Organ Toxicity—Single Exposure, Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes serious eye irritation; May cause drowsiness or dizziness
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust; Wash hands thoroughly after handling; Use only outdoors or in a well-ventilated area; If in eyes, rinse cautiously with water for several minutes
Routes of Exposure: Oral, inhalation, dermal, ocular
Target Organs: Central nervous system, eyes
Chemical: Diphenhydramine Hydrochloride
Concentration: 99% and above (pharmaceutical grade)
CAS Number: 147-24-0
EINECS Number: 205-687-2
Impurities: Trace organic compounds & moisture may be present at negligible levels
Stabilizing Additives: None reported
Inhalation: Move to fresh air immediately, get medical help if symptoms persist—monitor for difficulty in breathing or drowsiness
Skin Contact: Wash with soap and plenty of water—remove contaminated clothing, seek medical attention if skin irritation occurs
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, if present and easy, continue rinsing—seek medical help for persistent irritation
Ingestion: Do not induce vomiting unless directed by medical personnel; rinse mouth with water, seek immediate medical advice due to risk of central nervous system effects
Symptoms: Nausea, vomiting, confusion, agitation, blurred vision, dry mouth, dizziness
Extinguishing Media: Dry chemical, water spray, carbon dioxide, or foam extinguishers
Special Hazards: During fire, releases toxic fumes like carbon monoxide, carbon dioxide, hydrogen chloride
Protective Equipment: Firefighters need full protective gear including self-contained breathing apparatus
Fire/Explosion Risks: Product is not flammable, but can decompose at high temperatures leading to hazardous gases
Advice for Firefighters: Contain run-off, avoid inhalation of combustion byproducts, cool containers with water spray from a safe distance
Personal Precautions: Put on personal protective equipment—dust mask, gloves, goggles
Environmental Precautions: Prevent entry into sewers or waterways—contain spill with inert absorbent
Cleanup Methods: Sweep up and place in a suitable container for disposal, ventilate area and wash spill site after material pickup
Large Spills: Use non-sparking tools, avoid raising dust
Decontamination: Flush area with plenty of water—dispose cleaning materials securely
Handling: Wear protective clothing, avoid contact with skin and eyes, minimize dust generation and accumulation
Hygiene Practices: Wash thoroughly after handling, do not eat or drink in work area
Storage Conditions: Keep in tightly closed containers in a cool, dry, well-ventilated place—protect from light and moisture
Incompatible Materials: Strong oxidizers, acids, strong bases
Special Precautions: Segregate from foodstuffs, check containers regularly for leaks or degradation
Permissible Exposure Limits: Not established by OSHA or ACGIH for this compound
Engineering Controls: Work under local exhaust or fume hood, keep containers closed
Personal Protection—Eyes: Safety glasses with side shields or chemical goggles
Personal Protection—Skin: Chemical-resistant gloves and lab coat or protective suit
Personal Protection—Respiratory: Use NIOSH-approved dust respirator for dusty conditions
Other Protection: Wash hands before breaks and at end of workshift—remove contaminated clothing immediately
Appearance: White, crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
Melting Point: 166–170°C
Boiling Point: Decomposes
Solubility: Freely soluble in water, soluble in alcohol
pH (1% solution): 4.0 to 6.0
Vapor Pressure: Not available
Vapor Density: Not available
Relative Density: Not available
Partition Coefficient: log Pow = 3.3 (octanol/water)
Flash Point: Not applicable
Evaporation Rate: Not available
Decomposition Temperature: Decomposes before boiling
Flammability: Not flammable
Chemical Stability: Stable under normal conditions of use and storage
Conditions to Avoid: Heat, moisture, direct sunlight, sources of ignition
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Hydrogen chloride gas, nitrogen oxides, carbon monoxide, and carbon dioxide
Polymerization: Will not occur under normal handling
Acute Toxicity: Oral rat LD50 = 500–1000 mg/kg
Chronic Effects: Possible impacts from prolonged exposure include central nervous system depression, anticholinergic symptoms, dry mouth, blurred vision, constipation
Skin Corrosion/Irritation: Mild irritant
Serious Eye Damage/Irritation: Causes irritation, possible redness
Respiratory/Skin Sensitization: Not identified as a sensitizer
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity: Data insufficient
Reproductive Toxicity: Evidence of risk to fetus in animal studies, not fully established in humans
Target Organs: Central nervous system, eyes, gastrointestinal tract
Ecotoxicity: Not well-studied; avoid uncontrolled release to the environment—may be hazardous to aquatic life
Persistence/Degradability: Expected to have limited biodegradability—breakdown in wastewater depends on specific bacteria
Bioaccumulation Potential: Moderate, due to log Pow above 3
Mobility in Soil: Likely to be mobile in aqueous environments
Other Adverse Effects: Pharmaceutical waste in water systems linked to subtle impacts on aquatic organisms, further study needed
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations—do not discharge into waterways
Incineration: Suitable method by licensed chemical waste contractor
Contaminated Packaging: Must be disposed as chemical waste—triple rinse and puncture before disposal
Precautions: Handle according to safety guidelines to prevent accidental exposure
UN Number: Not regulated for transport
Proper Shipping Name: Not classified as dangerous good
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Special Precautions: Keep away from incompatible materials, secure to prevent shifting during transport
OSHA Status: Not hazardous under OSHA Hazard Communication Standard
TSCA Status: Listed
SARA Title III Section 311/312: Acute health hazard
SARA Title III Section 313: Not listed
California Proposition 65: Not listed
WHMIS (Canada): Class D-2B (Toxic Material Causing Other Effects)
EINECS/ELINCS: Listed
Other International Regulations: Complies with relevant local and international chemical safety regulations and reporting requirements
