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Product Name: Diosmin
Chemical Formula: C28H32O15
CAS Number: 520-27-4
Synonyms: 3’,5,7-Trihydroxy-4’-methoxyflavone, 7-rutinoside
Recommended Use: Pharmaceutical ingredient, dietary supplement
Supplier Details: Manufacturer and emergency contact info may come from specific provider. Use certified supplier contact for emergencies involving diosmin transport or lab handling.
GHS Classification: Not classified as hazardous under GHS guidelines
Physical Hazards: Mild dust hazard when handling powder; no explosive or flammable risk at room temperature
Health Hazards: Repeated inhalation of dust can cause slight respiratory irritation; direct contact with eyes or unprotected skin may create minor discomfort
Environmental Hazards: Large spills into water can disturb aquatic environments over time
Main Component: Diosmin 98%-100%
Impurities: May include hesperidin (<1%)
Formulation: Crystalline solid powder, light yellow in appearance
Excipients: None typically present in raw material
Inhalation: Remove exposed individuals to fresh air; seek medical advice if irritation persists
Skin Contact: Rinse skin with soap and water; remove contaminated clothing
Eye Contact: Flush eyes gently using water for at least 15 minutes; seek advice from a healthcare provider if discomfort continues
Ingestion: Rinse mouth, consult physician for persistent symptoms or accidental overdose; diosmin lacks acute oral toxicity but medical oversight supports safety
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or foam
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Fire Hazards: Combustion might release irritating gases (carbon oxides); diosmin does not strongly fuel fires
Advice for Firefighters: Control run-off water for environmental protection; diosmin residue creates slippery surfaces
Spill Response: Remove ignition sources, avoid dust creation; ventilate area before entering
Personal Precautions: Wear gloves, mask, and protective eyewear
Environmental Protection: Keep powder away from drains, water sources, and soils
Cleanup Methods: Sweep up, collect in secure container for disposal, use wet sweeping if needed for fine dust
Handling: Avoid inhaling dust or direct skin/eye contact; only process diosmin in well-ventilated settings
Safe Storage: Store in tightly closed container, away from moisture, light, strong acids, or oxidizing agents
Conditions to Avoid: High humidity, direct sunlight, prolonged air exposure may introduce degradation
Special Requirements: Use desiccator or similar moisture control method where long-term storage is needed
Engineering Controls: Local exhaust ventilation, safety hoods for large-scale handling
Personal Protective Equipment: Laboratory gloves, dust mask/respirator, safety goggles
Skin Protection: Wear laboratory coat; wash hands after use
Protection for Eyes/Face: Use splash-proof goggles or face shield
Occupational Exposure Limits: No established occupational exposure limits for diosmin; follow good industrial hygiene practices
Appearance: Light yellow fine powder or crystalline solid
Odor: Odorless or faintly sweet aroma
Melting Point: 270 – 275°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Slightly soluble in water, freely soluble in methanol and ethanol
Molecular Weight: 608.55 g/mol
pH: Not applicable in solid form
Auto-Ignition Temperature: Not determined
Partition Coefficient (log P): Approximately -0.91 (low fat solubility)
Vapor Pressure: Negligible at standard conditions
Flash Point: Not easily flammable
Chemical Stability: Stable under normal dry storage conditions
Reactivity: Reacts with strong acids, strong oxidizing agents
Decomposition: Thermal decomposition may release carbon monoxide, carbon dioxide
Hazardous Polymerization: Not known to occur
Incompatible Materials: Avoid strong oxidizers, moisture, sources of extreme heat
Acute Toxicity: Low toxicity by oral and dermal routes in animal studies
Chronic Effects: Long-term use as a supplement or medicine does not appear to trigger organ dysfunction; rare allergic reactions reported
Inhalation Effects: Dust can irritate respiratory tract
Skin/Eye Contact: May cause transient irritation
Carcinogenicity: Not classified by IARC, NTP, OSHA
Mutagenicity: No evidence of genetic damage in standard assays
Reproductive Toxicity: No effects observed in animal models
Aquatic Toxicity: No data on direct aquatic toxicity; likely to pose minimal risk in small quantities
Persistence/Degradability: Biodegradable under most natural conditions; breakdown occurs via microbial action
Bioaccumulation Potential: Low based on structure and low lipid solubility
Mobility in Soil: Likely to bind to soil particles, limited groundwater transport
Waste Disposal Methods: Dispose as non-hazardous laboratory waste following local and national regulations
Contaminated Packaging: Clean containers before recycling or dispose according to official guidance
Precautions: Minimize dust release during disposal; do not flush into surface water or municipal systems
Recommended Disposal Route: Incineration in approved facilities or landfill under controlled conditions
UN Number: Not classified as hazardous under current transportation regulations
Transport Hazard Class: Not regulated
Packing Group: Not classified
Proper Shipping Name: Diosmin
Special Precautions: Keep containers sealed and protected from moisture; avoid crushing or shaking during transit
Regulatory Listings: Listed under appropriate chemical inventories including TSCA and REACH
Labeling Requirements: No hazard symbols required; good handling practice statements should appear on label
Workplace Safety: OSHA hazard communication standard recommends basic chemical hygiene practices
Other Regulations: Not subject to special transport, environmental, or industrial restrictions beyond general chemical safety measures
