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Product Name: Diflufenican
Chemical Family: Pyridinecarboxamide
Synonyms: 2',4'-difluoro-2-methoxy-3-(trifluoromethyl)nicotinanilide
Recommended Use: Selective herbicide for pre- and post-emergence control in cereals and grasslands
Manufacturer: Contact details for supplier or distributor, including emergency contact phone number are usually printed on the label and transport documentation
CAS Number: 83164-33-4
UN Number: 3077 (when transported as dangerous goods)
Hazard Class: Acute toxicity, Environmental hazard
GHS Signal Word: Warning
Hazard Statements: Harmful if swallowed, May cause irritation to eyes and skin, Toxic to aquatic life with long lasting effects
Pictograms: Exclamation mark, Environment
Routes of Exposure: Inhalation, ingestion, dermal contact
Chemical Name: Diflufenican
Concentration: Technical products usually contain ≥98% pure Diflufenican
Impurities: Various inert or minor formulation additives depending on product
Molecular Formula: C19H11F5N2O2
Molecular Weight: 412.30 g/mol
EINECS Number: 617-588-1
Inhalation: Move victim to fresh air. Seek medical attention if symptoms develop.
Skin Contact: Remove contaminated clothing and rinse skin thoroughly with soap and water.
Eye Contact: Immediately flush eyes with plenty of clean water for at least 15 minutes and consult a doctor.
Ingestion: Rinse mouth. Do not induce vomiting. Call poison control or seek medical attention without delay.
Note to Physician: There is no specific antidote. Symptomatic treatment required.
Suitable Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Water spray may be used for larger fires.
Hazards from Combustion: Toxic fumes such as hydrogen fluoride, nitrogen oxides, and carbon oxides may be released.
Protective Equipment: Full protective clothing, self-contained breathing apparatus recommended for firefighters.
Special Procedures: Avoid runoff into water sources as it poses a risk to aquatic organisms. Keep containers cool with water spray.
Personal Precautions: Wear suitable protective equipment. Avoid dust generation and inhalation.
Environmental Precautions: Prevent product from entering drains, waterways, or soil.
Cleanup Method: Sweep up and shovel material into an appropriate container for disposal. Use absorbent material for spills of liquid formulations.
Disposal: Collect all waste material for proper disposal according to local regulations.
Handling: Avoid contact with skin, eyes, and clothing. Use only in well-ventilated areas. Wash thoroughly after handling.
Storage: Store in original, tightly sealed containers in a dry, cool, and well-ventilated location, away from food and animal feed.
Conditions to Avoid: Excessive heat, direct sunlight, moisture
Incompatible Materials: Strong acids, alkalis, and oxidizing agents
Exposure Limits: No occupational exposure limit assigned specifically for Diflufenican. Minimize exposure as a best practice.
Engineering Controls: Local exhaust ventilation required in enclosed or poorly ventilated areas.
Personal Protective Equipment:
Gloves (nitrile or neoprene), safety goggles, chemical-resistant clothing, suitable respiratory protection in case of dust or spray.
Hygiene Measures: Avoid eating, drinking, or smoking during use. Wash hands after use.
Appearance: Off-white to pale beige crystalline powder
Odor: Faint, not distinctive
Melting Point: 159–163°C
Boiling Point: Decomposes before boiling
Solubility: Poorly soluble in water (4.2 mg/L at 20°C), more soluble in organic solvents
Vapor Pressure: 4.6 x 10⁻⁷ mPa at 20°C
Density: 1.53 g/cm³ (at 20°C)
pH: 6.5–7.5 (1% aqueous suspension)
Flash Point: Not applicable—solid material
Chemical Stability: Stable under recommended handling and storage conditions.
Conditions to Avoid: Prolonged heat, UV light, or contact with moisture can lead to degradation.
Incompatible Substances: Strong bases, acids, and oxidizers
Decomposition Products: Acidic and basic hydrolysis may yield hazardous substances including hydrogen fluoride and nitrogen oxides.
Acute Toxicity: Oral LD50 (rat) >5000 mg/kg, Dermal LD50 (rat) >2000 mg/kg
Irritation: Slight skin irritant, moderate eye irritant
Sensitization: Not a skin sensitizer based on animal data
Chronic Exposure: Prolonged exposure can impact liver function in animal studies
Carcinogenicity: No evidence found in available data for increased cancer risk in humans.
Mutagenicity: Not mutagenic in standard testing
Other Effects: Symptoms of overexposure include vomiting, diarrhea, headache, and irritation of respiratory tract.
Persistence: Diflufenican is persistent in soil, with half-life from several weeks up to 12 months depending on conditions.
Bioaccumulation: Low potential for bioaccumulation in aquatic and terrestrial organisms
Aquatic Toxicity: Highly toxic to aquatic plants and algae (EC50 for green algae ~0.034 mg/L), less so for fish (LC50 for rainbow trout > 70 mg/L)
Other Organisms: Low toxicity to birds and mammals, low bee toxicity.
Mobility: Moderate to low; binds to soil particles, potential for runoff into waterways exists after heavy rain.
Waste Handling: Collected spill material and unused product should not be discharged into drains or the environment.
Method of Disposal: Chemical incinerator with afterburner and scrubber preferred; alternatively, landfill in accordance with local laws.
Contaminated Container Disposal: Empty containers should be triple-rinsed, punctured, and disposed of using approved facilities.
UN Number: 3077
Proper Shipping Name: Environmentally hazardous substance, solid, N.O.S. (contains Diflufenican)
Hazard Class: 9 (Miscellaneous dangerous substances and articles)
Packing Group: III
Marine Pollutant: Classified as marine pollutant
Labels Required: Miscellaneous dangerous goods and marine pollutant labels
Special Transport Notes: Store away from food and feed during transport. Prevent release to the environment.
Inventory Status: Listed in EINECS, TSCA, and other major chemical inventories
Labeling Requirements: Compliance with EU CLP Regulation (EC) No 1272/2008, OSHA Hazard Communication Standard referenced in SDS
Restrictions: Authorization or restriction conditions may apply under EU REACH depending on formulation and country of use.
Other Regulations: May be regulated as a hazardous substance under the Clean Water Act and CERCLA in the United States, or similar frameworks in other regions.
Worker Protection: Advised by local occupational safety guidelines.
