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Product Name: Diethylstilbestrol
Chemical Name: 4,4’-(1,2-diethyl-1,2-ethenediyl)diphenol
Synonyms: DES, Stilboestrol, Stilbestrol
CAS Number: 56-53-1
Molecular Formula: C18H20O2
Molecular Weight: 268.36 g/mol
Intended Use: Laboratory chemical, pharmaceutical synthesis
Manufacturer: Refer to product label
Emergency Contact: Local poison control / Emergency medical services
Classification: Carcinogen (Group 1, IARC), Reproductive Toxicant, Endocrine Disruptor
GHS Label Elements: Danger
Hazard Statements: Causes cancer, causes damage to fertility or unborn child, suspected of causing genetic defects, harmful if swallowed, toxic in contact with skin, may cause allergy or asthma symptoms
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms of Exposure: Nausea, headache, dizziness, abdominal pain, chronic exposure linked to cancers and reproductive harm
Precautionary Statements: Wear protective gloves/protective clothing/eye protection, avoid release to environment
Chemical Name: Diethylstilbestrol
Concentration: 100% (technical grade or as stated on label)
Impurities: May contain related phenolic compounds in trace amounts
CAS Number: 56-53-1
Inhalation: Remove victim to fresh air, support breathing, seek immediate medical attention if breathing difficulties present
Skin Contact: Take off contaminated clothing, flush affected area with plenty of water and soap, medical attention recommended for rash or irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, seek prompt medical advice
Ingestion: Rinse mouth, do not induce vomiting, seek medical help immediately
Most Important Symptoms: Hormonal imbalance, reproductive effects, possible nausea, headache, long-term cancer risk
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Specific Hazards: Carbon oxides, toxic fumes released when heated or combusted
Protective Equipment For Firefighters: Full protective clothing including self-contained breathing apparatus
Special Procedures: Move containers from risk area if safe to do, use water spray to cool containers
Personal Precautions: Avoid inhalation, avoid skin and eye contact, use personal protective equipment
Environmental Precautions: Prevent entry into drains, surface and groundwater, notify authorities if environmental contamination suspected
Spill Cleanup Methods: Wear suitable protective clothing, collect spilled material using inert absorbent, place in suitable, labeled waste container for disposal, clean contaminated area thoroughly with detergent and water
Handling: Use only in well-ventilated areas or chemical fume hood, avoid contact with skin, eyes, and clothing, keep away from sources of ignition, wash thoroughly after handling
Storage: Keep in tightly closed original container in a cool, dry, well-ventilated area, store away from incompatible materials and out of reach of unauthorized personnel, protect from light and moisture
Occupational Exposure Limits: No OSHA PEL or NIOSH REL listed; minimize exposure as much as possible
Engineering Controls: Use with local exhaust ventilation or chemical fume hood
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, respiratory protection if dust or vapor likely, use only with adequate ventilation, wash hands before breaks and end of work
Hygiene Measures: Do not eat, drink, or smoke around material; keep personal clothing separate from work clothing
Appearance: White to off-white crystalline solid
Odor: Odorless
Odor Threshold: Not determined
pH: Not applicable
Melting Point: 168-173 °C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, soluble in alcohol, acetone, chloroform
Vapor Pressure: Not determined (very low at room temperature)
Partition Coefficient (log Pow): 5.07
Flash Point: Not determined
Autoignition Temperature: Not determined
Decomposition Temperature: Above 300 °C
Viscosity: Not applicable
Chemical Stability: Stable under normal storage conditions
Conditions to Avoid: Heat, open flame, sources of ignition, exposure to sunlight, strong acids or bases
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, phenolic compounds
Polymerization: Will not occur under normal conditions
Acute Toxicity: LD50 (oral, rat): ~68 mg/kg
Chronic Toxicity: Known carcinogen and reproductive toxicant in humans and animals, repeated exposures linked to clear cell adenocarcinoma, reproductive tract abnormalities
Routes of Exposure: Oral, inhalation, dermal
Health Effects: Increased risk of breast, vaginal, cervical, and testicular cancers, infertility, birth defects, hormonal disturbances
Target Organs: Reproductive organs, endocrine system
Mutagenicity: Evidence in laboratory studies
Carcinogenicity: Classified as a human carcinogen (IARC Group 1)
Ecotoxicity: Toxic to aquatic organisms, long-lasting effects on aquatic environment, may cause endocrine disruption in wildlife
Persistence and Degradability: Slowly biodegradable, potential for long-term persistence
Bioaccumulative Potential: High potential for bioaccumulation due to lipophilicity
Mobility in Soil: Limited mobility, tends to bind to soils
Other Adverse Effects: Disrupts hormone activity in fish and amphibians, possible effects on bird reproductive health
Waste Treatment Methods: Dispose as hazardous waste according to local, state, and federal regulations
Contaminated Packaging: Treat empty containers as hazardous, remnants may pose health hazards
Disposal Recommendations: Incineration at certified hazardous waste facility preferred, do not allow inorganic residues into sewage or watercourses
UN Number: Not classified for transport under most regulations
Transport Hazard Class: Not regulated, but treat as toxic substance
Packing Group: Not classified
Environmental Hazards: Not a marine pollutant under typical transport guidelines, yet must prevent accidental release
Special Precautions: Ensure secure packaging, maintain manifest of transfer for regulatory compliance
TSCA Status: Listed
OSHA: Regulated as a carcinogen
SARA Title III: Not listed as an extremely hazardous substance
California Proposition 65: Listed as a substance known to the State of California to cause cancer and reproductive toxicity
Other State & International Regulations: Included on EU REACH, Australia AICS, Canada DSL, Japan ENCS lists; strict handling, use, and reporting obligations worldwide
