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Dibazol Material Safety Data Sheet

Identification

Chemical Name: Dibazol
Common Name: Bendazol
Chemical Formula: C8H10N4
Molecular Weight: 162.19 g/mol
Synonyms: 1-benzylbenzimidazole, Bendazolum
CAS Number: 86-92-0
Manufacturer: Manufacturer information needed based on supply source
Recommended Use: Vasodilator, pharmaceutical ingredient
Restrictions on Use: Not intended for use outside pharmaceutical manufacturing or scientific research settings

Hazard Identification

GHS Classification: Not classified as dangerous under GHS
Signal Word: Not applicable
Hazard Statements: May cause eye irritation, possibly mild skin irritation, could induce respiratory discomfort if excessively inhaled
Precautionary Statements: Avoid dust creation, do not eat or drink while handling, wash hands thoroughly after use
Physical Hazards: Not considered highly flammable or explosive under typical storage and handling conditions
Health Hazards: Prolonged exposure could cause mild irritation to eyes and mucous membranes, ingestion may lead to mild gastrointestinal symptoms
Environmental Hazards: Low risk to environment at normal concentrations, higher spills may pose local aquatic toxicity concerns

Composition / Information on Ingredients

Substance: Dibazol (Bendazol)
Purity: Greater than 98%
Impurities: Other benzimidazole derivatives possible below 1%
Stabilizers/Additives: None typically added

First Aid Measures

Inhalation: Remove from exposure area, seek fresh air, medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water, consult physician if irritation occurs
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, seek medical advice if irritation continues
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, seek medical guidance if large quantities are swallowed

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, or water spray
Unsuitable Media: High-pressure water streams may disperse powder
Specific Hazards from Combustion: Emits carbon monoxide, carbon dioxide, nitrogen oxides on decomposition
Special Protective Equipment: Firefighters wear self-contained breathing apparatus (SCBA) and protective clothing
Advice to Firefighters: Operate from upwind, avoid inhalation of smoke and gases, contain fire-fighting water to prevent local contamination

Accidental Release Measures

Personal Precautions: Wear gloves, eye protection, and dust mask
Environmental Precautions: Prevent entry into drains, sewers, surface water or soil
Cleanup Methods: Gently scoop or sweep up without generating dust, place in suitable labeled container for disposal, ventilate area well
Decontamination: Wash contaminated surfaces with soap and water, avoid creating slurry that could enter drains

Handling and Storage

Handling: Use only in well-ventilated areas, avoid breathing dust, prevent contact with eyes and skin by wearing personal protective equipment, keep away from food and beverages
Storage: Store in tightly sealed original containers, in a cool, dry, well-ventilated area, away from incompatible substances such as strong acids, oxidizers, direct heat and sunlight, store at room temperature but avoid freezing or excessive heat

Exposure Controls and Personal Protection

Permissible Exposure Limits: No specific occupational exposure limits assigned
Engineering Controls: Work in ventilated enclosure or fume hood, utilize local exhaust, monitor airborne concentrations in workspace
Personal Protective Equipment (PPE): Safety glasses or goggles, chemical-resistant gloves, laboratory coat, dust mask or respirator in case of excessive dust generation
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke while working, remove contaminated clothing

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or very slight benzimidazole-like
pH: Slightly basic in solution
Melting Point: 115–118°C
Boiling Point: Not readily determined, decomposes before boiling
Vapor Pressure: Not significant at ambient conditions
Solubility: Slightly soluble in water, freely soluble in ethanol or chloroform
Density: About 1.1 g/cm³
Partition coefficient (log P): Estimated 1.7–2.2
Other Data: No explosive or oxidizing properties noted

Stability and Reactivity

Chemical Stability: Stable under standard conditions, retains structure at room temperature
Reactivity: Not reactive under normal laboratory handling
Incompatible Materials: Strong acids, strong oxidizing agents
Conditions to Avoid: Moisture, strong heat sources, direct sunlight, open containers
Hazardous Decomposition Products: Combustion produces toxic nitrogen oxides, benzene derivatives

Toxicological Information

Acute Toxicity: Low oral toxicity in animal studies, estimated LD50 (oral, rat) above 500 mg/kg
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms of Overexposure: Nausea, vomiting, headache, mild skin and eye irritation, drowsiness in large doses
Sensitization: Not considered a skin sensitizer
Carcinogenicity: Not listed by IARC, NTP, or OSHA as carcinogen
Mutagenicity: No known mutagenic activity under normal usage
Repeated Dose Toxicity: No data indicating long-term organ damage in mammals at therapeutic doses

Ecological Information

Ecotoxicity: Low toxicity reported for aquatic organisms, limited data available
Persistence and Degradability: Potential for slow degradation in water and soil
Bioaccumulation: Not expected to bioaccumulate significantly, moderate log P value
Mobility in Soil: Moderate mobility, may leach with water flow if spilled in large quantities
Other Adverse Effects: Use caution to minimize discharge into the environment, as chronic effects are not fully assessed

Disposal Considerations

Disposal Methods: Collect waste for incineration or disposal in authorized chemical landfill under local, state, and federal regulations
Empty Container Precautions: Triple rinse containers, dispose as hazardous waste
Special Instructions: Do not discharge into drains, waterways, or uncontrolled environments

Transport Information

UN Number: Not assigned for Dibazol
UN Proper Shipping Name: Not regulated as dangerous goods
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: No Marine Pollutant assigned
Transport Precautions: Protect from physical damage and moisture, keep containers tightly sealed during transit

Regulatory Information

TSCA Status: Not listed for commercial purposes as bulk chemical in the US
REACH Status: Registration might apply for quantities above 1 ton/year in EU
SARA Title III: Not classified under hazardous substances
California Proposition 65: Not listed
Labelling Requirements: Pharmaceutical standards apply, label with product and hazard details, handle following GMP and institutional guidelines
Other Regulations: Federal, state, and local regulations may apply; users encouraged to verify compliance status before importing or manufacturing in new regions