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Product Name: Diatrizoic Acid
Synonyms: 3,5-Diacetamido-2,4,6-triiodobenzoic acid; Angiografin; Triombrin
Chemical Formula: C11H9I3N2O4
CAS Number: 117-96-4
Manufacturer: Contact local supplier or hospital pharmacy
Recommended Uses: Radiographic contrast media in medical imaging, diagnostic purposes
Emergency Contact: Reference to local poison control or emergency health service
Classification: Not classified as hazardous under GHS, but direct contact or ingestion can impact health
Adverse Effects: Irritation to skin, eyes, and respiratory tract; possible allergic response in sensitive individuals
Label Elements: Warning notice for use only under trained supervision; keep out of children’s reach
Precautionary Statements: Avoid splashing, inhaling dust or vapors, or swallowing; use with appropriate protection
Notable Health Hazards: May cause nausea, vomiting, rash, or breathing issues in sensitive groups
Chemical Name: Diatrizoic Acid
Concentration: 98-100% (remainder inert components or water in prepared solutions)
Impurities: Typically less than 2%; includes water, trace organic or inorganic contaminants
Additives: Pharmaceutical forms may contain sodium/calcium salts, stabilizers, preservatives per formulation
Exposure Limits: No established workplace limits for diatrizoic acid; follow standard chemical hygiene practices
Inhalation: Move affected person to fresh air and keep at rest. Seek medical help if symptoms persist.
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids. Continue washing and seek medical care.
Ingestion: Rinse mouth. Do not induce vomiting unless directed by medical personnel.
Advice to Medical Personnel: Treat symptomatically, monitor for hypersensitivity reactions or specific organ impacts.
Suitable Extinguishing Media: Use foam, dry chemical, CO2, or water spray for nearby fires.
Hazardous Combustion Products: Toxic iodine, nitrogen oxides, and carbon oxides may form upon heating.
Fire-Fighting Precautions: Wear self-contained breathing apparatus, protective clothing to avoid exposure to decomposition products.
Specific Hazards: Powder may aid in spreading fire by dust if dispersed.
Advice for Firefighters: Keep containers cool by spraying with water if exposed to fire.
Personal Precautions: Evacuate area of unprotected personnel. Limit dust. Wear gloves, eye protection, dust mask if powder is present.
Environmental Precautions: Prevent product from entering water systems, soil, or drains.
Containment: Use inert absorbent materials to collect spilled liquid. For solids, scoop into appropriate waste container.
Cleanup Method: Wash area with soap and water after bulk removal. Ventilate area well.
Disposal Guidance: Place waste in properly labeled containers; do not mix with common trash.
Safe Handling Practices: Use in well-ventilated areas, avoid direct contact, do not eat or drink nearby. Maintain good hygiene practices.
Storage Requirements: Keep container tightly closed, store in cool, dry place; protect from light and moisture.
Incompatible Materials: Avoid strong oxidizers, reducing agents, and incompatible reactive substances.
Storage Location: Secure area, away from unauthorized personnel, away from food and feed.
Special Precautions: Label containers clearly; regularly inspect for leaks, degradation.
Engineering Controls: Use local exhaust ventilation to reduce exposure to airborne dust or vapor.
Personal Protection Equipment: Lab coat or gown, chemical-resistant gloves, safety goggles, dust mask or respirator when powder is handled.
Hygiene Measures: Wash hands thoroughly after handling and before eating or drinking.
Exposure Monitoring: Regular checks if used over long periods in occupational settings.
Special Precautions: Remove and wash contaminated clothing before reuse; avoid prolonged or repeated exposure.
Appearance: White to off-white solid, crystalline powder
Odor: Odorless
pH (solution): Ranges from 5 to 7 (dependent on concentration)
Melting Point: 300°C (decomposes)
Solubility: Slightly soluble in water, increased solubility in basic solutions
Boiling Point: Not applicable — decomposes
Vapor Pressure: Not significant at room temperature
Density: About 2.1-2.2 g/cm³
Partition Coefficient (log Kow): Approximately 0.16
Viscosity: Not applicable for solid
Flash Point: Not flammable under normal use
Molecular Weight: 613.912 g/mol
Chemical Stability: Remains stable at room temperature in sealed original packaging, if kept dry and away from light.
Conditions to Avoid: Excessive heat, moisture, and exposure to light may lead to degradation.
Incompatible Materials: Strong oxidizers, strong acids and bases, certain metals.
Hazardous Decomposition Products: Iodine vapors, nitrogen oxides, carbon oxides upon combustion or heated breakdown.
Reactivity: Generally unreactive with most substances in storage forms intended for lab or medical use.
Routes of Exposure: Inhalation, ingestion, dermal and ocular contact.
Acute Toxicity: Low to moderate acute toxicity; reported oral LD50 in rat: >5000 mg/kg.
Symptoms: Headache, dizziness, gastrointestinal upset, possible allergic response, rare serious anaphylactic reaction.
Chronic Toxicity: Prolonged or repeated exposure not well studied, but occupational cases rare.
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No conclusive evidence for carcinogenic, mutagenic, or reproductive risks under normal handling.
Medical Observations: Watch for rashes, fever, breathing difficulties after exposure; rare nephrotoxicity has been reported in high dose or hypersensitive patients.
Sensitization: May cause reactions in people with iodine or contrast-media hypersensitivity.
Environmental Persistence: Moderately persistent in soil and water; not readily biodegradable.
Bioaccumulation: Low risk — does not tend to build up in organisms due to low logKow.
Aquatic Toxicity: Can cause adverse effects in aquatic species if released in significant quantities.
Soil Impact: Minimal binding to soil, may leach into groundwater if improperly disposed.
Other Information: Avoid uncontrolled releases; no indication of significant ozone depletion or air pollution potential noted.
Waste Treatment Methods: Dispose of unused material and contaminated absorbents according to local, regional, and national regulations.
Incineration: Preferred method for disposal in chemical waste incinerators equipped for halogenated compounds.
Landfill: Acceptable only in approved facilities with measures to prevent groundwater contamination.
Container Disposal: Empty containers may retain residue. Triple-rinse containers and follow regulatory requirements.
Avoid Sewage Disposal: Never discharge into environment or municipal sewer systems unless permitted by authorities.
UN Number: Not regulated as a dangerous good for transport by road, air, or sea.
Proper Shipping Name: No specific classification for land, water, or air transport.
Hazard Class: Not classified as hazardous for transportation
Packing Group: Not applicable
Special Precautions: Transport in sealed, clearly labeled containers. Keep away from foodstuffs.
Environmental Hazards: Not classified as marine pollutant, still recommended to avoid release during shipping.
Global Inventory Listings: Listed on US TSCA, EU REACH, Australia AICS, Canada DSL, Japan ENCS, and other chemical inventories.
Specific Regulations: No special restrictions for lab or medical use beyond pharmaceutical or laboratory standard controls.
OSHA Hazards (US): Not classified as hazardous substance but handle as laboratory chemical.
WHMIS (Canada): Not classified controlled.
EU Classification: Not classified as hazardous under Regulation (EC) 1272/2008 (CLP).
State or Local Regulations: May require reporting if released to environment in quantity, check local regulations for discharge, disposal, and emergency planning.
