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Material Safety Data Sheet: Diacetone Glucose

Identification

Product Name: Diacetone Glucose
Synonyms: 1,2:3,5-Di-O-isopropylidene-α-D-glucofuranose, Diacetone-d-glucose
CAS Number: 2595-98-4
EC Number: 220-969-9
Intended Use: Laboratory chemicals and research applications
Supplier Information: Manufacturer and distributor contact details including address, phone, and emergency number
Recommended Uses: Organic synthesis, research and development

Hazard Identification

GHS Classification: Not classified as hazardous according to GHS or OSHA regulations
Hazard Statements: Dust may form explosive mixture with air. Eye or skin irritation possible after direct contact.
Precautionary Statements: Avoid prolonged inhalation of dust. Avoid unprotected contact with skin and eyes. Maintain proper airflow.
Signal Word: None required
Pictogram: None
Other Hazards: Combustible dust risk if large amounts generate dust clouds. Users handling powder must follow dust management control.

Composition / Information on Ingredients

Chemical Name: Diacetone Glucose
Molecular Formula: C9H16O6
Concentration: >98% by weight
Impurities: Trace levels of residual solvents from synthesis route, typically below 0.5%
Other Components: No biologically active or hazardous additives introduced during manufacture

First Aid Measures

Inhalation: Remove individual to fresh air. Seek medical help if respiratory symptoms show up or persist.
Skin Contact: Rinse with water and mild soap. Remove contaminated clothing. Seek medical advice for irritation or allergic response.
Eye Contact: Flush with plenty of clean water for 10-20 minutes; keep eyelids separated. Get medical attention if discomfort continues.
Ingestion: Rinse mouth thoroughly with water and drink plenty of water. Contact physician if discomfort or unusual symptoms develop.
General Info: Remove from exposure. Provide symptomatic support. Keep emergency responders informed about substance.

Fire-Fighting Measures

Suitable Extinguishing Media: Foam, carbon dioxide, dry chemical powder, or water spray
Unsuitable Media: Avoid using full water jet for extinguishing due to splash and dusting risk
Specific Hazards: Thermal decomposition may produce carbon oxides. Dust accumulation in closed areas may create explosion risk.
Protective Equipment for Firefighters: Standard protective clothing plus self-contained breathing apparatus.
Firefighting Procedures: Use water spray to cool containers. Remove persons from danger zone. Avoid inhaling combustion fumes.

Accidental Release Measures

Personal Precautions: Avoid breathing dust. Ensure adequate ventilation. Use recommended protections. Remove ignition sources.
Environmental Precautions: Prevent runoff or spills from entering drains, waterways, or soil.
Cleanup Methods: Gather spilled material mechanically and collect in closed, labeled containers for disposal. Wash area with water.
Other Considerations: Wear respiratory protection and gloves if cleaning significant release. Take precautions against static discharge.

Handling and Storage

Precautions for Safe Handling: Minimize dust generation and exposure. Use outdoors or in well-ventilated spaces. Handle away from open flames.
Hygiene Measures: Wash hands after handling. Do not eat, drink, or smoke during use. Remove contaminated clothing and wash before reuse.
Safe Storage Conditions: Store in tightly closed original container in cool, dry, well-ventilated area. Protect from moisture and direct sunlight. Keep away from strong oxidizers and incompatible substances.
Storage Temperature: Recommended between 2°C–25°C. Avoid freezing or overheating.
Incompatible Materials: Oxidizing agents, acids, and strong bases
Packaging: Use inert, sealed containers constructed of materials like HDPE or glass for stability.

Exposure Controls and Personal Protection

Control Parameters: No established occupational exposure limits from OSHA, NIOSH, or ACGIH
Engineering Measures: Local exhaust ventilation or general ventilation to control airborne dust
Personal Protective Equipment:

  • Respiratory Protection: NIOSH-approved particulate respirator for dust when necessary
  • Hand Protection: Chemical-resistant gloves (nitrile recommended)
  • Eye Protection: Safety goggles or face shield
  • Skin Protection: Lab coat or chemical apron
Workplace Controls: Emergency eyewash stations and safety showers accessible.
Environmental Controls: Prevent dust accumulation and minimize emissions to air or water.

Physical and Chemical Properties

Appearance: White to off-white crystalline solid
Odor: Odorless or faint sweet
Odor Threshold: Not determined
pH Value: Not available (not readily soluble in water at room temperature)
Melting Point / Range: 110–112°C
Boiling Point: Decomposes before boiling
Flash Point: Not established for solid, precaution with dust formation
Flammability: Combustible as dust
Explosion Limits: Not determined; avoid dust clouds
Vapor Pressure: Negligible at 20°C
Solubility: Slightly soluble in water, freely soluble in alcohol and ether
Partition Coefficient (Log Pow): Not established
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not applicable (solid)

Stability and Reactivity

Chemical Stability: Stable under recommended conditions of storage and use
Reactivity: No hazardous reactivity under standard handling conditions
Hazardous Reactions: Reacts strongly with oxidizing agents
Conditions to Avoid: Open flame, excessive heat, moisture, generation of airborne dust, static discharge
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide under fire conditions or decomposition
Polymerization: Does not polymerize
Incompatible Materials: Acids, alkalis, oxidizers

Toxicological Information

Acute Toxicity: Low; oral rat LD50 estimated > 2000 mg/kg
Routes of Exposure: Skin contact, eye contact, inhalation of dust, ingestion
Symptoms: Redness or irritation at large or prolonged exposures; no chronic adverse effects documented on occupational contact
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Genotoxicity: No known mutagenic or reproductive risks
Repeated Dose Toxicity: No evidence of cumulative or delayed effects under normal use

Ecological Information

Ecotoxicity: Practically non-toxic to aquatic life at typical environmental concentrations
Mobility in Soil: Predicted low mobility due to low solubility
Persistence and Degradability: Likely biodegradable; not expected to persist in environment
Bioaccumulation Potential: Not expected to bioaccumulate in aquatic organisms
Aquatic Organism Toxicity: No measured acute toxicity data available. Based on structure, minimal hazard presumed.
Additional Information: Avoid uncontrolled release into environment. Follow local waste regulations.

Disposal Considerations

Disposal Methods: Collected material should be sent to approved chemical waste disposal facility. Preferable method is incineration in licensed plant.
Contaminated Packaging: Triple rinse and dispose as regulated waste. Do not reuse containers for other materials.
Disposal of Spills: Sweep up and dispose with solid waste according to federal, state, and local jurisdiction.
Precautions: Do not release into drains or surface waters. Avoid landfill where possible by using chemical waste incineration.

Transport Information

UN Number: Not regulated as dangerous goods
Proper Shipping Name: No restriction
Transport Hazard Class: None
Packing Group: None
Label: No specific marking required on transit containers.
Environmental Hazards: Not a marine pollutant or hazardous airborne particulate in standard quantities
Special Precautions: Avoid mechanical shock or containers breakage during transport

Regulatory Information

TSCA Inventory: Listed
ECHA REACH Status: Registration not required under Annex IV/V of Regulation (EC) 1907/2006
US SARA Title III: Not listed as hazardous or toxic
California Prop 65: This chemical is not known to state of California to cause cancer or reproductive toxicity
Canadian DSL: Listed
Other Standards: Not subject to ADR, IMDG, or IATA regulations for hazardous materials;
Workplace Labelling: Usual labeling standards apply for workplace chemical safety