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Product Name: Dexrazoxane
Chemical Formula: C11H16N4O4
CAS Number: 24584-09-6
Synonyms: ICRF-187, Zinecard, Totect
Manufacturer: Refer to current supplier label
Recommended Use: Pharmaceutical, cytoprotective agent
Emergency Contact: Chemtrec +1-800-424-9300, local poison control numbers
Address: Refer to supplier label
Product Code: As labeled on the supplied packaging
GHS Classification: Skin and eye irritant, possible reproductive hazard
Hazard Statements: Irritation to mucous membranes, skin redness, eye discomfort, respiratory irritation, may harm unborn children
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Precautionary Statements: Avoid inhaling dust, wash exposed areas thoroughly, use only with adequate ventilation, do not handle without protection
Potential Health Effects: Short-term exposure may cause transient discomfort, prolonged or repeated exposure increases health risks
Target Organs: Eyes, respiratory tract, skin, reproductive system
Main Ingredient: Dexrazoxane
Concentration: Typically above 95% by weight
Impurities: Trace levels of manufacturing by-products, less than 1% each
Other Ingredients: No significant excipients identified with pharmaceutical grade
Molecular Weight: 268.27 g/mol
EC Number: 246-379-6
Eye Contact: Rinse with water for at least 15 minutes, remove contact lenses if present, seek medical advice
Skin Contact: Wash with soap and water, remove contaminated clothing, consult a doctor for persistent irritation
Inhalation: Move to fresh air, support breathing, contact emergency services if symptoms persist
Ingestion: Rinse mouth, do not induce vomiting unless instructed by medical personnel, seek immediate medical attention
Note to Physicians: Symptomatic treatment, monitor for delayed health effects due to cytoprotective properties
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Unsuitable Media: High-pressure water jets can spread powder
Special Hazards: Decomposition releases toxic fumes including nitrogen oxides, carbon monoxide
Protective Equipment: Self-contained breathing apparatus and full protective suit
Firefighting Procedures: Approach fire from upwind side, keep containers cool with water mist, prevent runoff into drains
Personal Precautions: Wear gloves, lab coat, suitable respirator or dust mask, safety goggles
Methods for Clean-Up: Sweep or scoop spillage to suitable container for disposal, avoid raising dust, ventilate area
Environmental Precautions: Prevent entry into sewers or waterways
Decontamination: Wash affected area with water and non-reactive detergent
Reporting: Notify safety supervisor or environmental officer according to facility policy
Handling: Handle away from food and drinks, apply good hygiene practices, avoid skin and eye contact, use engineering controls
Storage Conditions: Store in tightly sealed original containers, keep away from direct sunlight, moisture, heat sources
Incompatible Materials: Strong acids, strong oxidizers, strong bases
Specific Use(s): Use in accordance with pharmaceutical protocols and safety procedures
Special Requirements: Access restricted to trained personnel, maintain log of inventory and usage
Occupational Exposure Limits: No specific OSHA or ACGIH exposure limits established
Engineering Controls: Use local exhaust ventilation, closed handling systems or fume hood
Personal Protection: Nitrile gloves, long-sleeve lab apparel, chemical splash goggles, dust mask or respirator compatible with pharmaceutical powders
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing before entering common areas, avoid eating or drinking while handling
Environmental Controls: Use handling practices that minimize escape into the environment
Appearance: White to off-white crystalline powder
Odor: Slight or odorless
Odor Threshold: Not established
pH: Neutral to slightly acidic in water
Melting Point: 187–193°C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable under normal conditions
Explosive Properties: None identified
Vapor Pressure: Negligible at ambient conditions
Solubility: Freely soluble in water
Partition Coefficient (log Kow): Not determined
Viscosity: Not applicable
Density: About 1.45 g/cm³
Chemical Stability: Stable under recommended storage and handling conditions
Decomposition Products: Nitrogen oxides, carbon oxides, potentially hazardous low molecular weight compounds
Reactivity: May react with strong oxidizers and acids
Polymerization: Not expected to occur
Hazardous Reactions: None if product is handled and stored as prescribed
Acute Toxicity: LD50 data for laboratory animals above 5000 mg/kg (oral, rat)
Eyes and Skin: Causes mild irritation, extended exposure increases risk of dermatitis and redness
Inhalation: Dust may cause respiratory tract irritation, coughing, sneezing
Ingestion: May cause nausea, vomiting, abdominal pain
Chronic Effects: Animal studies show potential for reproductive effects, no known carcinogenicity in humans
Sensitization: Not identified as a sensitizer in available studies
Other Health Effects: Potential for delayed effects following repeated exposure
Aquatic Toxicity: Harmful to aquatic life at high concentrations
Persistence and Degradability: Limited environmental degradation data
Bioaccumulation: No significant bioaccumulation expected
Mobility in Soil: Water-soluble, may migrate through soil to groundwater
Other Adverse Effects: Data on long-term environmental impact not fully established
Waste Treatment Methods: Dispose as pharmaceutical waste in accordance with local, regional, and national regulations
Unused Material: Return to licensed hazardous waste disposal contractor, do not release to sewage
Contaminated Packaging: Incinerate or treat as hazardous material, remove all identifying labels before disposal
Recommended Disposal Containers: Rigid, leak-proof, labeled as hazardous material
RCRA Status: Substance not listed, manage as potentially cytotoxic pharmaceutical waste
UN Number: Not regulated for transport as hazardous material
Proper Shipping Name: Pharmaceutical product, not otherwise specified
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Labels Required: None for non-bulk quantities
Special Provisions: Follow routine protective packaging and storage methods
Environmental Hazards: Avoid uncontrolled release during transport
EU Regulations: Not classified as a dangerous substance under EU Directives, handle per pharmaceutical safety protocols
US Federal Regulations: Not included in major toxics lists but should be managed per OSHA hazardous drug rules
State Regulations: States may require added controls for cytotoxic drugs above threshold quantities
WHMIS Classification (Canada): Not controlled, subject to pharmaceutical facility standards
Other Regulatory Compliance: Sync recordkeeping with DEA, FDA, or local health ministry requirements as necessary
Worker Training: Required for all handlers, with written standard operating procedures available at work site
