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Product Name: Dexamethasone Sodium Phosphate
Chemical Formula: C22H28FNa2O8P
CAS Number: 2392-39-4
Synonyms: Decadron Phosphate, Hexadrol Phosphate, Maxidex
Recommended Use: Anti-inflammatory pharmaceutical, corticosteroid therapy
Manufacturer: Contact supplier or pharmaceutical company for details
Emergency Contact: Refer to local poison center or chemical safety office
GHS Classification: Not classified as hazardous for transport or handling in the amounts used in healthcare settings. Large-scale quantities may require more precautions.
Health Hazards: Eye irritation, skin irritation, may cause respiratory tract irritation upon inhalation of powder or dust
Environmental Hazards: Possible aquatic toxicity — avoid release to environment
Signal Word: No signal word required under GHS; consult site-specific hazard assessment
Pictograms: None required under GHS for pharmaceutical end use
Precautionary Statements: Avoid inhalation, ingestion, contact with eyes or skin; keep out of reach of children
Chemical Name: Dexamethasone Sodium Phosphate
Concentration: Pure substance in bulk; refer to product label for pharmaceutical mixtures
Impurities: May contain water and trace manufacturing residues (each supplier will give specific info)
Molecular Weight: 516.41 g/mol
Inhalation: Move to fresh air, assist breathing if required, consult a physician for any respiratory symptoms
Skin Contact: Wash exposed area with soap and plenty of water, remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present
Ingestion: Rinse mouth, drink water if conscious, seek medical advice promptly
Symptoms: Redness, soreness, local irritation, systemic effects unlikely with single small exposures
Advice for Physicians: Treat supportively, manage airway and circulation
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Hazards from Combustion Products: May evolve fumes of carbon oxides, phosphorus oxides, sodium oxides
Protective Equipment: Wear self-contained breathing apparatus and protective gear
Special Procedures: Use caution in confined spaces, avoid inhalation of smoke or dust
Personal Precautions: Wear gloves, mask, eye protection, close off area to limit dust spreading
Methods for Cleanup: Sweep up without creating dust, transfer to sealed container, wash area with water
Environmental Precautions: Prevent spillage from entering drains, sewers, surface water, and soil
Disposal: Collect waste and label for regulated disposal in line with local chemical waste programs
Precautions for Safe Handling: Work in well-ventilated area, avoid breathing dust or accidental contact
Hygiene Measures: Wash hands after handling, avoid eating or drinking in handling area
Storage Conditions: Store in cool dry place, keep container tightly closed, protect from light and moisture
Incompatible Materials: Strong oxidizers, acids, avoid unnecessary exposure to heat or sunlight
Occupational Exposure Limit: No specific international standards for pharmaceutical handling; minimize exposure
Engineering Controls: Use local exhaust ventilation or work in fume hood when possible
Personal Protective Equipment: Gloves (nitrile or latex), safety goggles, lab coat or apron, dust mask for powders
Special Precautions: Keep work areas clean, avoid contamination of clothing and work surfaces
Appearance: White to off-white powder or crystalline solid
Odor: Odorless
Boiling Point: Data not available due to decomposition before boiling
Melting Point: Around 230°C (with decomposition)
Solubility: Freely soluble in water
pH (solution): Typically between 7.0–9.0 (for injectable formulations)
Vapor Pressure: Low; negligible for powder
Partition Coefficient (logP): −1.1 to −1.5 (as sodium phosphate salt)
Chemical Stability: Stable under normal conditions of handling and storage
Possible Reactions: Hydrolyzes slowly in water over long periods; sensitive to heat, light, and acids
Incompatible Substances: Strong oxidizing agents, strong acids or bases
Hazardous Decomposition: Carbon oxides, sodium oxides, phosphorus oxides by thermal decomposition
Polymerization: No known hazardous polymerization
Acute Toxicity: Oral LD50 (rat): >3000 mg/kg; low acute toxicity for normal handling
Routes of Exposure: Inhalation of dust, skin and eye contact, accidental ingestion
Symptoms: Irritation to eyes and skin, rare allergic reactions, excessive exposure may cause corticosteroid effects (immune suppression, glucose changes)
Chronic Effects: Prolonged, high-level exposure can cause adrenal suppression and systemic corticosteroid complications
Carcinogenicity: No evidence of carcinogenicity in humans
Reproductive Effects: May affect fetal development if used in pregnancy — refer to medical risk-benefit assessment
Mutagenicity: Not considered mutagenic
Aquatic Toxicity: Data limited; avoid release due to possible effects on aquatic organisms
Persistence and Degradability: Not expected to be persistent but incomplete data for environmental breakdown
Bioaccumulation: Unlikely due to water solubility and rapid metabolism
Mobility in Soil: Readily mobile; avoid contamination of environment
Other Adverse Effects: Use responsible disposal practices to limit ecological impact
Waste Disposal: Must follow local and national regulations for pharmaceutical and chemical waste
Recommendation: Use licensed waste contractor; incineration preferred for bulk material
Contaminated Packaging: Dispose as chemical waste, decontaminate or incinerate empty containers
Prohibited Disposal: Do not pour in drains, septic systems, or regular garbage
UN Number: Not regulated for transport as hazardous material in small quantities
Transport Labeling: None required under UN, DOT, IMDG, IATA for standard packages
Special Precautions: Avoid rough handling, keep dry and away from incompatible substances
Regulatory Status: Check destination requirements for large bulk or international shipments
EU Regulations: Classified under medicinal product exceptions for most end uses
US Regulations: Controlled as a prescription medication; non-hazardous chemical under OSHA for typical use
WHMIS (Canada): D2B (toxic material causing other effects) in large industrial quantities
TSCA: Exempt as a drug product
Label Elements: Follow local and facility-specific pharmaceutical labeling requirements
Employer Duties: Train staff in safe handling, keep SDS up to date, ensure PPE use
