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Product Name: Dexamethasone Acetate
Chemical Name: 9-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate
Synonyms: Dexamethasone 21-acetate, Decadrol Acetate
Molecular Formula: C24H31FO6
Molecular Weight: 434.5 g/mol
CAS Number: 1177-87-3
Manufacturer: Information provided on request
Recommended Uses: Research, pharmaceutical intermediate, synthetic corticosteroid applications
Classification: Not classified as hazardous according to GHS for bulk chemical usage but carries risks associated with corticosteroids
Eye Contact: Can cause irritation, redness, pain
Skin Contact: Possible mild irritation, may absorb through skin with extended exposure
Inhalation: May cause respiratory tract irritation; avoid dust generation
Ingestion: May be harmful if swallowed, may cause symptoms consistent with corticosteroid exposure
Target Organs: Adrenal glands, skin, immune system
Chronic Effects: Risk of endocrine disruption and immune suppression with repeated exposure
Chemical Component: Dexamethasone Acetate
Concentration: ≥98% pure
Impurities: Trace levels of byproducts from synthesis, below 1%
Other Constituents: No significant hazardous stabilizers or preservatives present
Eye Exposure: Immediately flush eyes with water for at least 15 minutes, seek medical attention if irritation persists
Skin Exposure: Wash with plenty of soap and water, remove contaminated clothing, get medical help for persistent discomfort
Inhalation: Move to fresh air, keep at rest, provide oxygen if breathing is difficult, seek medical help for symptoms
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, call poison control or physician for further advice
General Advice: Always seek medical attention for prolonged or severe symptoms
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Special Hazards: Emits toxic fumes like carbon monoxide, carbon dioxide, hydrogen fluoride on combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Firefighting Procedures: Move containers from fire area if safe. Prevent runoff from entering drains or water supply.
Personal Precautions: Use PPE—gloves, eye protection, dust mask; avoid generating dust
Environmental Precautions: Avoid release to environment, prevent spills from entering drains, sewers, or waterways
Clean-up Methods: Sweep up without generating dust, place in labeled waste container, ventilate area, wash spill site after material pickup
Disposal: Dispose of in accordance with local regulations (see Disposal Considerations)
Handling: Minimize dust generation and accumulation, use with adequate ventilation, avoid contact with skin and eyes
Storage Area: Store in a cool, dry, well-ventilated place; keep container tightly closed away from incompatible materials such as strong oxidizers
Security: Restrict access to trained personnel, keep away from food, drink, and products meant for consumption
Handling Precautions: Wash hands and exposed skin thoroughly after handling; do not breathe dust
Exposure Limits: No established OSHA PEL or ACGIH TLV for Dexamethasone Acetate
Engineering Controls: Use local exhaust ventilation, safety showers, and eye wash stations
Personal Protective Equipment:
- Respiratory: Use NIOSH-approved dust respirator or appropriate filter in high dust concentrations
- Skin: Wear protective gloves such as nitrile or latex
- Eye: Safety goggles or chemical splash goggles
- Other: Laboratory coats, closed shoes, avoid direct skin contact, routine hand washing
Appearance: White or off-white crystalline powder
Odor: Odorless or faint odor
pH: Not available (not applicable for solids)
Solubility: Practically insoluble in water; soluble in ethanol, chloroform
Melting Point: 216–220°C
Boiling Point: Decomposes before boiling
Density: 1.28 g/cm³
Vapor Pressure: Negligible
Flash Point: Not determined, not expected to pose flammability risk under normal conditions
Partition Coefficient (n-octanol/water): Approx. 1.82
Other Properties: Stable under recommended storage conditions, not volatile under ambient temperatures
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Non-reactive with most common substances under normal operating conditions
Conditions to Avoid: Extreme heat, humidity, exposure to light, oxidizing agents
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: May form toxic fumes of carbon monoxide, carbon dioxide, hydrogen fluoride during decomposition
Acute Toxicity: Not classified as acutely toxic, data limited; high doses may lead to symptoms similar to those of corticosteroid overdose
Potential Health Effects:
- Inhalation: Irritant to respiratory tract, coughing, headache
- Skin: Low absorption expected with short contact, possible mild irritation
- Eyes: Possible transient redness and irritation
- Ingestion: May be harmful, can cause headache, dizziness, suppression of immune function
Chronic Exposure: Prolonged or repeated exposure may affect adrenal gland function, induce immunosuppression, impact metabolic and hormonal balance
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Other Data: Animal studies show corticosteroid-related effects at doses well above typical occupational exposures
Ecotoxicity: Data on direct environmental impact limited; corticosteroids in water can disrupt aquatic organisms’ hormonal systems
Persistence: Compound shows moderate persistence, not readily biodegradable
Bioaccumulation: Potential for low bioaccumulation based on structure and predicted partition coefficient
Mobility in Soil: Typically immobile, low solubility in water reduces movement
Aquatic Impact: Chronic exposure risks for aquatic species at significant concentrations
Other Adverse Effects: Avoid unauthorized discharge to environment to minimize long-term risk
Waste Disposal: Dispose as hazardous chemical waste through authorized chemical waste collection service; follow specific pharmaceutical and hazardous chemical disposal guidelines
Container Disposal: Triple rinse and puncture empty containers before disposal; follow local regulations for chemical containers
Recommended Practice: Consult with environmental authorities prior to large-scale disposal
Persistence: Do not allow entry to surface waters or soil to keep residues out of environment
UN Number: Not regulated as dangerous goods under major transport regulations
Transport Hazard Class: No assigned hazard class for ground, air, or sea transport in most jurisdictions
Packing Group: Not assigned
Labels Required: None for transport; internal handling requires chemical labeling
Special Precautions: Transport in tightly closed containers, protect from sunlight, vibration, and physical damage
Safety, Health and Environmental Regulations: Dexamethasone Acetate not specifically regulated under TSCA, REACH, or other international chemical inventories, but may fall under local pharmaceutical or research use controls
OSHA: Not listed as hazardous under OSHA Hazard Communication Standard
WHMIS (Canada): Not classified, but handled as controlled product due to pharmacological activity
SARA Title III: Not designated an Extremely Hazardous Substance
Other Regulations: User must comply with all applicable laws concerning health, safety, and environmental protection where substance is handled or used
