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Product Name: Desonide
Chemical Name: 11β,21-Dihydroxy-16α,17α-isopropylidenedioxy pregna-1,4-diene-3,20-dione
Synonyms: Tridesonide, Desonate
CAS Number: 638-94-8
Recommended Use: Topical corticosteroid for skin disorders
Manufacturer: Pharmaceutical companies specializing in corticosteroid medications
Contact Information: See individual supplier's contact for details
Emergency Phone Number: Refer to regional poison control centers or supplier emergency lines
GHS Classification: Not classified as hazardous per OSHA regulations
Health Hazards: May cause irritation on skin or eye contact, and inhalation of dust or mist can cause respiratory tract irritation
Route of Exposure: Skin contact, eye contact, inhalation, ingestion
Target Organs: Skin, eyes, respiratory tract, potentially adrenal glands with chronic exposure
Signal Word: None
Hazard Statements: Overuse or misuse may result in side effects such as skin thinning, burning sensation, or suppression of skin immune response
Active Ingredient: Desonide (pure) 100%
Impurities: May contain minor amounts of related corticosteroid derivatives or synthesis byproducts, exact composition varies by supplier
Other Ingredients: None, unless provided as formulated creams, ointments, or gels containing water, emollients, emulsifiers, and preservatives. For this MSDS, only pure Desonide is considered
Inhalation: Move person to fresh air, seek medical attention for unusual symptoms
Skin Contact: Wash with soap and water, remove contaminated clothing, seek help for persistent irritation
Eye Contact: Rinse with clean water for several minutes while holding eyelids open, obtain medical attention if discomfort remains
Ingestion: Rinse mouth, seek medical advice if larger quantities are swallowed or symptoms appear
Most Important Symptoms: May cause local skin, eye irritation; systemic effects rare except with chronic overexposure
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Special Hazards: Dust or powder may form combustible mixtures with air; burning may release irritating or toxic fumes such as carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Avoid inhaling smoke, keep containers cool with water spray
Personal Precautions: Use personal protective equipment, avoid creating dust or aerosol
Environmental Precautions: Prevent further leakage or spillage, keep away from drains and surface water
Methods for Cleanup: Scoop up or vacuum spilled material, place in labeled waste container, ventilate area, wash residue with water and detergent
Handling: Avoid contact with skin, eyes, and clothing; minimize dust generation and accumulation; use only in well-ventilated areas
Storage: Store in tightly closed containers, keep in a dry, cool, well-ventilated place protected from light and moisture, store away from food and incompatible substances such as strong oxidizers
Occupational Exposure Limits: No specific limits established for Desonide
Engineering Controls: Use local exhaust ventilation
Personal Protection: Wear chemical-resistant gloves, safety goggles, lab coat or apron; for bulk handling, NIOSH-approved respirator may be needed
Hygiene Measures: Wash hands thoroughly after use, do not eat, drink, or smoke when handling the substance
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (solid powder)
Melting Point: 220-224°C
Boiling Point: Not determined
Flash Point: Not applicable
Solubility: Practically insoluble in water, soluble in alcohol and acetone
Density: No data available
Vapor Pressure: Not applicable
Partition Coefficient: logP (octanol/water) approximately 2.5-3
Decomposition Temperature: No data available
Chemical Stability: Stable under normal storage and handling conditions
Incompatible Materials: Strong oxidizing agents
Reactivity: Not chemically reactive in normal applications
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly other toxic vapors if heated strongly
Conditions to Avoid: Excessive heat, open flame, exposure to strong light or humidity
Acute Toxicity: Data limited in humans; low toxicity expected at therapeutic doses
Chronic Toxicity: Prolonged or excessive use can cause skin atrophy, suppression of hypothalamic-pituitary-adrenal (HPA) axis
Irritation: May cause local irritation, redness, burning on skin or eyes
Sensitization: Allergic reactions rare, but possible
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: Effects not fully studied; as a steroid, caution urged during pregnancy
Routes of Exposure: Primarily skin, some risk from accidental inhalation of powder or ingestion
Ecotoxicity: No specific data available; corticosteroids may affect aquatic organisms at high levels
Persistence/Degradability: Substance expected to be partially persistent in environment
Bioaccumulation: Potential unknown, structurally related corticosteroids show minimal bioaccumulation
Mobility in Soil: Expected to bind to soil, limited mobility
Other Adverse Effects: Large spills can disrupt local wastewater treatment processes if not contained properly
Waste Disposal Methods: Dispose of as pharmaceutical waste under local, regional, or national legislation
Container Disposal: Rinse empty containers, manage as controlled waste
Additional Notes: Do not discharge into drains, water bodies, or soil; burning generates toxic gases
UN Number: Not assigned
Proper Shipping Name: Not regulated for transport
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Environmental Hazards: None known
Special Precautions: Protect from extreme temperature and moisture; ship in sealed packaging
US Federal Regulations: Not listed as a hazardous chemical under SARA Title III or CERCLA
TSCA Status: Not listed
OSHA: Not regulated as hazardous
State Regulations: No state-level hazardous designation established
EU Regulations: Not classified as hazardous under CLP Regulation (EC) No 1272/2008
Other International Regulations: Complies with schedules relevant to pharmaceutical corticosteroids
