© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Denaverine Hydrochloride
Chemical Formula: C19H25NO2.HCl
CAS Number: 13447-18-2
Synonyms: 3-(4-Hydroxybenzyl)-1,1-Dimethylpiperidinium Chloride
Manufacturer: Supplied through veterinary pharmaceutical distributors
Recommended Use: Pharmaceutical ingredient, antispasmodic use in veterinary medicine
Emergency Contact: Local poison control center, onsite medical officer
Restrictions: For professional veterinary use; not for human therapeutic purposes
GHS Classification: Acute toxicity - Oral, Category 4; Eye irritation, Category 2A; Specific target organ toxicity after single exposure
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation. May cause drowsiness or dizziness.
Pictograms: Exclamation mark
Symptoms of Exposure: Throat irritation, headache, nausea, gastrointestinal discomfort, possible respiratory effects with very high dust concentrations
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Wear eye protection and gloves. Do not eat, drink, or smoke while using this product.
Denaverine Hydrochloride: 98%–100%
Impurities: Not expected to exceed 2%; identify exact contaminants via manufacturer batch record
Molecular Weight: 331.9 g/mol
Physical Form: Fine, off-white to yellowish powder
Odor: Slight to none
Inhalation: Move individual to fresh air immediately. Seek medical attention for persistent cough or breathing difficulty.
Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with water and soap until all material is removed. Get medical advice for any irritation.
Eye Contact: Rinse eyes gently with plenty of water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present. Contact an eye specialist.
Ingestion: Rinse mouth with water. Do not induce vomiting unless recommended by a medical professional. Provide medical supervision as soon as possible.
Symptoms to Observe: Abdominal pain, nausea, headache, drowsiness, mucous membrane irritation; monitor for serious adverse reactions.
Medical Attention: Bring MSDS to medical team if possible; symptomatic treatment required
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen chloride gas
Protective Equipment: Positive pressure self-contained breathing apparatus, full protective suit
Special Fire-Fighting Procedures: Avoid inhalation of smoke or fumes. Move containers from fire area if safe. Cool exposed drums with water spray. Prevent run-off from entering drains or surface water.
Personal Precautions: Wear suitable gloves, goggles, lab coat or coveralls, and a particulate respirator
Environmental Precautions: Prevent further leakage. Avoid discharge into drains, surface water, and soil
Containment Methods: Sweep up using non-sparking equipment. Dust suppression with damp cloth or mop
Cleanup Procedures: Collect in a secure, labeled container. Clean surface with soapy water. Dispose as hazardous pharmaceutical waste
Decontamination: Rinse spill area thoroughly with water after material cleanup
Handling: Avoid dust formation. Use only in well-ventilated environments, safest under fume hood. Utilize proper personal protective equipment for all handling steps. Do not inhale dust or allow contact with skin, eyes, or clothing. Avoid ingestion.
Storage Conditions: Store in original, tightly sealed container. Keep in a cool, dry place. Shield from direct sunlight, moisture, and incompatible materials.
Segregation: Separate from strong acids, strong oxidizers.
Specific Requirements: Check and comply with any local or facility-specific pharmaceutical handling regulations or restrictions.
Incompatibilities: Do not store in places with volatile strong acids or oxidizers
Control Parameters: No established occupational exposure limit (OEL) specific for Denaverine Hydrochloride; handle as a hazardous pharmaceutical active ingredient
Engineering Controls: Fume hood or local exhaust ventilation in dispensing, mixing, or weighing areas
Personal Protective Equipment: Chemical-resistant gloves (nitrile or equivalent), splash-proof safety goggles, lab coat or chemical-resistant suit, particulate respirator with a P3 or N95 filter rating
Hygiene Measures: Wash hands after handling and before breaks or meals. Do not eat, drink, or smoke in work areas. Remove contaminated clothing and launder before reuse.
Environmental Protection: Use closed systems or isolators for weighing large quantities. Control dust generation at every step
Appearance: Off-white to light yellow powder
Odor: Faint or odorless
pH (1% solution in water): 2.5–4.5
Melting Point: 140°C to 150°C
Boiling Point: Not applicable
Solubility: Freely soluble in water, soluble in methanol, practically insoluble in ether or chloroform
Vapor Pressure: Negligible
Partition Coefficient (log Pow): Data not available
Relative Density: Approx. 1.18 g/cm³
Evaporation Rate: Not volatile under ambient conditions
Decomposition: Begins above 180°C with possible emission of hazardous fumes
Stability: Stable under standard handling, storage, and temperature conditions
Reactive Hazards: Avoid contact with strong oxidizing or reducing agents, acids
Conditions to Avoid: Extreme temperatures, rapid temperature changes, excess moisture, direct sunlight
Decomposition Products: On combustion may yield carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride gas
Polymerization: No risk under standard conditions
Container Materials: Use high-density polyethylene or glass; do not use reactive metals for long-term storage
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Oral LD50 in rats approximately 300–500 mg/kg
Skin Irritation: Slight irritation possible after direct or prolonged exposure
Eye Irritation: Expected to be irritating to eyes on contact
Respiratory Effects: High concentrations of dust may irritate mucous membranes and upper airways
Chronic Effects: No long-term carcinogenicity or reproductive toxicity data in literature
Symptoms: Drowsiness, headache, dizziness, abdominal pain, diarrhea in case of significant exposure
Sensitization: No dermal sensitization reported from available data
Ecotoxicity: Data for aquatic environment unavailable; avoid release to water bodies or sewer systems
Persistence and Degradability: Drug molecules may persist in environment; breakdown products unknown
Mobility in Soil: Expected to be mobile in aqueous medium due to high solubility
Bioaccumulative Potential: No evidence for significant bioaccumulation potential
Other Adverse Effects: Pharmacological activity in aquatic and terrestrial organisms cannot be ruled out; restrict environmental emission
Waste Treatment Methods: Collect solid waste in labeled, tightly closed hazardous waste containers. Do not dispose in general waste stream. Professional hazardous waste contractor to be used.
Disposal of Contaminated Packaging: Rinse with plenty of water and dispose as hazardous material. Do not attempt disposal with common municipal waste arrangements.
Environmental Caution: Strict measures required to prevent contamination of groundwater, soil, sewage. Document all pharmaceutical discards under national hazardous waste guidelines.
UN Number: Not assigned specifically for Denaverine Hydrochloride
Proper Shipping Name: Pharmaceuticals, not otherwise specified
Transport Hazard Class: Not regulated by ADR/RID, IMDG, IATA as a dangerous good but maintain packaging integrity
Packing Group: Not classified
Special Precautions: Ship in original packaging with clear labeling. Secure containers to prevent tipping. Prepare documentation for emergency response personnel.
Environmental Hazards: Not an identified marine pollutant; avoid environmental exposure during transit
Compliance: Adhere to local laws regarding controlled substances, pharmaceuticals, and hazardous chemicals
Labeling Requirements: Product labeling must carry hazard pictograms, precautionary statements, product identifier, and manufacturer information
Workplace Regulation: Occupational health authority codes for controlling exposure to hazardous pharmaceutical active substances should be applied
International Inventories: Not typically listed on public industrial chemical inventories
Restrictions: Sale or handling limited to regulated veterinary practices or pharmaceutical manufacturing.
