© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Substance name: Demeclocycline Hydrochloride
Chemical formula: C21H21ClN2O8•HCl
Other names: Declomycin, Demeclocycline HCl
CAS Number: 64-73-3
Recommended use: Pharmaceutical ingredient; antibiotic compound
Manufacturer: [Name/contact details of manufacturer]
Emergency phone: [Supplier emergency contact]
Classification: Acute toxicity (oral, dermal, inhalation), Specific organ toxicity (single exposure), Eye irritation
GHS label elements: Signal word: Warning
Hazard statements: Harmful if swallowed or inhaled; causes serious eye irritation; may cause respiratory irritation
Symbols: Exclamation mark
Precautionary statements: Avoid breathing dust; wear eye and face protection; wash hands after handling; keep container closed
Chemical identity: Demeclocycline Hydrochloride
Concentration: 100% by weight
Impurities: None relevant for classification
Chemical family: Tetracycline derivative, Antibiotic
Inhalation: Remove to fresh air; seek medical attention if symptoms develop
Skin contact: Wash skin thoroughly with soap and water; remove contaminated clothing
Eye contact: Rinse cautiously with water for at least 15 minutes; hold eyelids open; consult an ophthalmologist
Ingestion: Rinse mouth with water; do not induce vomiting unless instructed by a medical professional; seek immediate medical help
Most important symptoms/effects: Irritation of eyes, respiratory tract, gastrointestinal discomfort, possible allergic reactions
Notes for physicians: Symptomatic treatment; consider risk of phototoxic or allergic reactions common with tetracyclines
Suitable extinguishing media: Water spray, dry powder, foam, carbon dioxide
Specific hazards: May produce toxic fumes of carbon monoxide, nitrogen oxides, and hydrogen chloride on combustion
Protective equipment for firefighters: Self-contained breathing apparatus, full protective clothing
Advice: Move containers from fire area if possible; prevent runoff into drains
Personal precautions: Avoid dust creation; wear appropriate personal protective equipment
Environmental precautions: Do not let product enter drains, sewers, or watercourses
Methods for cleanup: Sweep or vacuum up avoiding dust; transfer to a suitable, labeled disposal container; wash spill area with copious water; ventilate area; dispose of waste in accordance with regulations
Handling: Avoid contact with skin, eyes, and clothing; do not breathe dust; keep containers tightly sealed when not in use; use in a well-ventilated area
Storage: Store in a cool, dry, well-ventilated place; keep away from light and incompatible substances; keep container tightly closed; avoid sources of ignition and strong oxidizers
Occupational exposure limits: No established value
Engineering controls: Use exhaust ventilation to minimize exposure; use process enclosures or local ventilation
Personal protective equipment: Protective gloves (nitrile recommended), chemical safety goggles, lab coat, respiratory protection if ventilation is inadequate
Hygienic practices: Wash hands thoroughly after handling; do not eat, drink, or smoke during handling; keep protective equipment clean
Appearance: Yellow crystalline powder
Odor: Odorless
pH: ~2.0-3.0 (10% solution)
Melting point: 220°C (decomposes)
Boiling point: Not applicable (decomposes before boiling)
Solubility: Soluble in water
Vapor pressure: Not available
Density: ~1.6 g/cm³
Partition coefficient (log Kow): Not available
Flash point: Not flammable
Auto ignition temperature: Not available
Evaporation rate: Not applicable
Viscosity: Not applicable
Chemical stability: Stable under normal temperatures and pressures; decomposes in light
Reactivity: No dangerous reactions known under normal conditions
Conditions to avoid: Exposure to heat, light, moisture; strong oxidizing agents
Incompatible materials: Strong oxidizers, acids, bases
Hazardous decomposition products: Toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen chloride
Acute toxicity (oral): LD50 (rat): 660 mg/kg
Acute toxicity (inhalation): Data not available
Acute toxicity (dermal): Data not available
Chronic effects: May affect liver and kidney function; possible effects on bone and teeth formation (especially in children); photosensitivity reactions
Irritation: Causes eye, skin, and respiratory irritation
Sensitization: May cause allergic reactions in sensitized individuals
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Reproductive toxicity: Suspected to cause adverse effects on fetal development; contraindicated in pregnancy
Symptoms of overexposure: Nausea, vomiting, diarrhea, skin rash, increased sensitivity to sunlight, headache
Ecotoxicity: Harmful to aquatic organisms; may cause long-term effects in the aquatic environment
Persistence and degradability: Biodegradation is limited; may persist in environment
Bioaccumulation potential: Data not available
Mobility in soil: Expected to be fairly mobile, especially in wet or sandy soils
Other adverse effects: Antibiotic activity could disrupt microbial communities in soil or water; avoid uncontrolled release into the environment
Waste management: Collect and dispose of product, contaminated materials, and packaging through licensed hazardous waste contractors
Disposal regulations: Disposal must comply with local, regional, national, and international regulations
Contaminated packaging: Remove product residues and dispose of packaging as hazardous waste
UN number: Not classified as a dangerous good under transport regulations
UN proper shipping name: Not regulated
Transport hazard class: Not applicable
Packing group: Not applicable
Marine pollutant: Not regulated
Special precautions: Prevent physical damage and contact with incompatible substances during transportation
Inventory status: Listed or exempted on major chemical inventories
Labeling requirements: Comply with chemical safety and hazardous substance labeling regulations per OSHA Hazard Communication Standard (29 CFR 1910.1200)
Risk phrases: Harmful if swallowed; causes eye irritation
Safety phrases: Keep out of reach of children; avoid contact with skin and eyes; in case of accident or if you feel unwell, seek medical advice immediately
Restrictions: Authorized for pharmaceutical manufacturing use only; not for consumer or food use
