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Product Name: Dasatinib
Chemical Name: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
CAS Number: 302962-49-8
Molecular Formula: C22H26ClN7O2S
Molecular Weight: 488.01 g/mol
Relevant Uses: Oncology research, pharmaceutical ingredient, active compound for CML treatment
Supplier: Pharmaceutical distributor, hospital pharmacy, research laboratory
Classification: Toxic if swallowed; Hazardous to aquatic life with long lasting effects; May cause reproductive toxicity; Sensitizing to skin and respiratory tract
Harmful Effects: Causes organ damage at repeated exposure; Possible carcinogen and mutagen; Risk of allergic or asthmatic symptoms
Precautionary Statements: Avoid skin and eye contact; Prevent inhalation of dust or aerosols; Do not eat, drink, or smoke near this material; Store away from food and animal feed
Signal Word: Danger
Pictogram: Skull-and-crossbones, exclamation mark, health hazard, environment
Chemical Substance: Dasatinib monohydrate
Concentration: Greater than 98% active ingredient
Impurities: Trace residual solvents, regulatory limit as per manufacturer release specification
Additives: Not present in pure form; formulated tablets include excipients such as lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate
Inhalation: Move the person to fresh air, support breathing with oxygen if available, seek medical attention
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, consult a physician
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, do not rub, seek ophthalmic care
Ingestion: Rinse mouth, do not induce vomiting, give water if conscious, seek urgent medical help
Symptoms: Nausea, headache, respiratory irritation, dizziness, allergic response or rash
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, or appropriate foam
Hazards During Fire: Emits toxic fumes under combustion such as nitrogen oxides, carbon monoxide, hydrogen chloride, sulfur oxides
Personal Protection: Firefighters need positive pressure self-contained breathing apparatus, full protective gear
Special Procedures: Cool closed containers exposed to fire with water spray to prevent rupture
Personal Provisions: Use chemical resistant gloves, safety goggles, and disposable lab coat; avoid dust formation
Environmental Precautions: Prevent entry into drains and waterways; contain spill immediately
Cleanup Methods: Sweep up and place in a suitable container for disposal using non-sparking tools, ventilate affected area
Decontamination: Clean residue with damp sponges; dispose of contaminated materials according to local regulations
Safe Handling: Use in well-ventilated areas or chemical fume hood; avoid exposure to skin, eyes, clothing; wash hands after use
Storage Conditions: Keep container tightly closed, store in original packaging, in a secure area at 20-25°C; avoid freezing and direct sunlight
Segregation: Separate from food, drink, animal feed, oxidizers, acids, and unrelated pharmaceuticals
Stability Precautions: Protect from moisture, excessive heat, incompatible substances
Occupational Exposure Limits: No OEL set; use occupational control banding systems or refer to company-specific limits
Engineering Controls: Laboratory fume hood, effective exhaust ventilation, closed transfer utilities
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, disposable respirator (P2 or P3 for powders), chemical-resistant gown
Hygiene Measures: Do not eat, drink or smoke near usage, practice regular hand washing, frequent glove changes
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable in solid form; slightly acidic in solution
Melting Point: Around 280°C (decomposes)
Water Solubility: Sparingly soluble (less than 1 mg/mL)
Solubility in Organic Solvents: Slight in methanol, DMSO, ethanol
Partition Coefficient: logP ≈ 2.1
Vapor Pressure: Negligible
Density: Not available
Formulation Note: Tablets include excipients for oral administration
Chemical Stability: Stable under standard lab conditions for pharmaceuticals
Thermal Decomposition: May produce toxic fumes above melting point
Incompatible Substances: Strong acids, strong bases, oxidizing agents
Hazardous Polymerization: Not expected to occur
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, hydrogen chloride gas, sulfur oxides
Acute Toxicity: Harmful if swallowed (LD50 values reported in rodents: approximately 200-400 mg/kg oral)
Chronic Toxicity: Prolonged exposure can affect kidney, liver, bone marrow, cause immunosuppression, risk for reproductive and teratogenic effects
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Carcinogenicity: Positive findings in some animal studies; evidence is not conclusive for humans
Mutagenicity: Positive results in in vitro tests; genotoxic hazard cannot be ruled out
Other Effects: Headache, respiratory discomfort, rash, potential allergic reactions; possible impact on fertility
Ecotoxicity: Very toxic to aquatic organisms, danger of long-term adverse effects in aquatic environment
Persistence and Degradability: Poorly biodegradable, persists in water and soil for extended periods
Bioaccumulative Potential: Some potential for bioaccumulation shown in aquatic models
Mobility in Soil: Low mobility, binds rapidly to soil and sediment
Other Environmental Data: Treat all residues and contaminated disposals as hazardous waste for water and soil
Waste Disposal: Collect and place in sealed, labeled, approved chemical waste containers
Disposal Methods: Incinerate at a licensed facility capable of handling pharmaceutical cytotoxics
Contaminated Packaging: Triple rinse, render unusable, discard following hazardous waste protocols
Local Regulations: Follow country- and region-specific pharmaceutical waste rules; consult certified waste contractor
Avoid Release: Do not pour into drains, waterways or regular waste systems
UN/NA Number: Not classified as hazardous for transport under most regulations
Proper Shipping Name: Pharmaceutical product, not otherwise specified
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions: Transport in secure packaging, avoid moisture, prevent release during handling
International Regulations: Check IATA, IMDG, local carriage rules for cytotoxic or hazardous pharmaceuticals
Labelling: Toxic, environment hazard, health hazard pictograms as per GHS
Relevant Regulation: Classified under OSHA Hazard Communication (29 CFR 1910.1200), REACH, CLP Regulation, and local standards for cytostatic drugs
Pharmaceutical Listing: Prescription-only medicine in most countries, controlled use in certified facilities
Other Considerations: Employers must ensure training and PPE supply for workers; keep records for workplace monitoring; report accidental exposures as part of safety compliance
