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Product Name: Daptomycin
Chemical Family: Cyclic lipopeptide antibiotic
CAS Number: 103060-53-3
Synonyms: Cubicin, LY 146032
Manufacturer: Various pharmaceutical manufacturers including Merck & Co.
Recommended Use: Treatment of infections caused by Gram-positive bacteria including MRSA
Product Code: Not specifically assigned; refer to distributor or manufacturer
Emergency Contact: Poison Control Center, or local emergency services
Address: Refer to supplier for country-specific distribution
Classification: Non-hazardous under normal laboratory handling; not assigned a GHS classification
Signal Word: Not required
Hazard Statements: May cause respiratory irritation, eye irritation, or skin irritation on direct contact
Precautionary Statements: Avoid inhalation, ingestion, and contact with skin and eyes; practice good laboratory hygiene
Pictograms: None required by GHS; treat as pharmaceutical agent
Other Hazards: Large-scale exposure may impact those with allergies to similar drug classes
Target Organ Effects: Liver, kidneys (from high or chronic exposure, according to animal studies)
Chemical Name: Daptomycin
Concentration: Typically ≥ 98% for pharmaceutical grade material
Molecular Formula: C72H101N17O26
Molecular Weight: 1620.67 g/mol
Impurities: Trace amounts of fermentation byproducts or residual solvents (as per manufacturer’s specifications)
Additives: Lyophilized powder may contain sodium hydroxide or other pH adjusters; refer to product insert
Inhalation: Move individual to fresh air; seek medical attention for persistent symptoms
Skin Contact: Immediately wash affected area with soap and water; remove contaminated clothing
Eye Contact: Flush eyes with running water for at least 15 minutes, lifting eyelids as needed; seek medical advice
Ingestion: Rinse mouth thoroughly with water; do not induce vomiting; consult a physician immediately
Note for Physicians: Symptomatic and supportive treatment only; no known antidote
Potential Symptoms: Allergic reactions, local irritation, possible nausea on ingestion
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry powder, or foam
Special Hazards: Decomposition releases toxic fumes including nitrogen oxides and carbon monoxide
Protective Equipment for Firefighters: Wear self-contained breathing apparatus (SCBA) with full protective suit
Further Information: Avoid inhalation of residues; control run-off to prevent environmental contamination
Explosion Data: Not explosive; not sensitive to mechanical impact
Combustion Products: Irritating gases and particulate matter can arise from incomplete combustion
Personal Precautions: Wear laboratory gloves, eye protection, and face mask to avoid contact and inhalation
Environmental Precautions: Prevent material from entering drains, surface, or ground water
Methods for Containment and Cleanup: Collect spilled powder with an inert material such as damp cloth or paper towels; avoid dust generation; place in clearly labeled waste container
Decontamination: Clean area with detergent and water after bulk removal; ventilate space
Disposal: See Disposal Considerations for approved methods
Incident Reporting: Notify laboratory supervisor and local environmental health authority if required
Handling: Use within a controlled, well-ventilated laboratory setting; avoid creating dust or aerosols; avoid skin, eye, and clothing contact
Storage Conditions: Store in tightly closed original container in a dry, cool, and well-ventilated area, between 2–8°C; protect from light and moisture
Incompatible Materials: Strong oxidizing agents, acids, or bases
Packaging Materials: Use original packaging or compatible, chemical-resistant containers for storage
Safety Precautions in Use: Handle only by trained personnel using intake controls for pharmaceutical-grade antibiotics
Occupational Exposure Limits: No established exposure limits available for Daptomycin from OSHA, ACGIH, NIOSH, or EU agencies
Engineering Controls: Use fume hood or other local exhaust to minimize exposure; ensure laboratory airflow does not recirculate contaminated air
Personal Protective Equipment: Gloves (nitrile or neoprene), laboratory gown, safety goggles, N95 or higher respirator for powder handling
Hygiene Measures: Wash hands and face before breaks and at the end of procedures; never eat, drink, or smoke in work areas
Environmental Exposure Controls: Use spill trays and ensure proper containment to avoid release outside contained areas
Special Requirements: Practice double-gloving for high-exposure operations; dispose of PPE promptly after lab sessions
Appearance: White to off-white powder or lyophilized cake
Odor: Odorless or slight organic odor
pH (solution): 4.0–5.5 (reconstituted at manufacturer-recommended concentration)
Melting Point: Not determined; decomposes before melting
Solubility: Freely soluble in water, particularly in sodium hydroxide- or phosphate-buffered saline
Boiling Point: Not applicable; decomposes before boiling
Vapor Pressure: Not applicable (non-volatile solid)
Density: Not reported; typical for organic powders
Partition Coefficient: LogP < 0 (reported as hydrophilic)
Formulation Properties: Supplied as sterile, preservative-free lyophilized cake
Other Physical Data: Degrades under prolonged light or elevated temperature
Chemical Stability: Stable under recommended storage and handling conditions
Incompatibility: Strong oxidizers, strong acids or bases can degrade product
Decomposition Products: Carbon monoxide, NOx, CO2 upon thermal decomposition
Reactivity: No hazardous polymerization or unexpected reactivity noted
Hazardous Reactions: None under normal processing or storage
Environmental Factors: Sensitive to prolonged exposure to moisture, light, and air
Acute Toxicity: LD50 (rat, oral): > 5000 mg/kg; low acute toxicity expected based on animal data
Potential Health Effects: Local irritation to eyes, mucous membranes; allergic reactions observed in sensitive individuals; systemic toxicity rare but may include liver or kidney impact after repeated exposure
Chronic Effects: Potential risk of sensitization after prolonged skin contact or inhalation
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity: Animal studies show no evidence of genotoxicity
Reproductive Toxicity: No reproductive toxicity in animal models at therapeutic doses
Sensitization: Skin or respiratory sensitization possible in those already allergic to lipopeptide antibiotics
Other Data: Typical dose for humans is 4–6 mg/kg intravenously once daily under medical supervision
Ecotoxicity: Harmful to aquatic organisms at high concentrations; potential for antibiotic resistance selection in aquatic environments
Persistence and Degradability: Not rapidly biodegradable; persists in environment leading to possible accumulation
Bioaccumulative Potential: Low due to high water solubility and low logP
Mobility in Soil: Moderate mobility; moves through runoff if not contained
Other Adverse Effects: Contributes to selective pressure for resistant bacteria in wastewater streams
Wastewater Treatment: Typical pharmaceutical wastewater protocols do not always fully remove microgram quantities; advanced treatments required
Waste Treatment Methods: Dispose of unused material or contaminated items as hazardous pharmaceutical waste according to federal, state, and local regulations
Container Disposal: Triple-rinse containers and treat as laboratory waste; follow incineration procedures if available
Sewage Disposal: Never release into surface drains; consult municipal authorities for permission and guidance if accidental release occurs
Special Instructions: Handle by incineration or high-temperature treatment facilities; follow manufacturer's and regulatory protocols
Contaminated Packaging: Dispose using the same protocols as active pharmaceutical ingredients; prevent reuse of containers
UN Number: Not assigned for finished pharmaceutical grade
Proper Shipping Name: Not regulated for land, air, or sea transport in the U.S. and EU
Hazard Class: Not applicable
Packing Group: Not assigned
Transport Labeling: No specific labeling required; ship in original, sealed packaging
Special Precautions for Transportation: Ship under temperature-controlled conditions; avoid exposure to extreme heat, freezing, or sunlight
Other Transport Data: Consult with airline or shipping company for any pharmaceutical-specific carriage policies
US Regulations: Not listed as hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200); regulated as prescription pharmaceutical
EU Regulations: Not classified as hazardous according to EU CLP Regulation (EC) No 1272/2008
Local and State Regulations: Vary by jurisdiction; consult local chemical safety authorities
Inventory Listings: Active pharmaceutical ingredient; found on U.S. FDA Orange Book, EMA EudraPharm, and similar regulatory databases
Other Regulations: Subject to drug diversion and prescription regulations worldwide; disposal must follow hazardous waste standards where applicable
Worker Protection: Covered under laboratory biosafety and chemical hygiene plans; emergency exposure protocols in effect
Product Registration: Registered for medical use in U.S., EU, Canada, Australia, Japan, and many other countries
