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Product Name: Dapoxetine Hydrochloride
Chemical Formula: C21H23NO•HCl
CAS Number: 129938-20-1
SYNONYMS: Dapoxetine HCl, Priligy
Recommended Use: Pharmaceutical intermediate for premature ejaculation treatment
Manufacturer: [Contact details required for emergency situations and further technical information]
Classification: Acute toxicity (oral, category 4), Eye irritation (category 2A)
Label Elements: Pictogram—Exclamation mark (GHS07)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation
Precautionary Statements: Wash hands thoroughly after handling, avoid contact with eyes, do not eat, drink, or smoke when using, wear protective gloves and eye protection
Component: Dapoxetine Hydrochloride
Concentration: Typically 98% or higher, pharmaceutical grade
Other Ingredients: Trace synthesis byproducts, water (moisture content less than 1%)
Impurities: Controlled under pharmacopoeia standards, usually below 0.1%
Inhalation: Move affected person to fresh air, seek medical attention if symptoms develop such as coughing or shortness of breath
Skin Contact: Remove contaminated clothing, wash exposed skin with soap and water, consult physician if irritation occurs
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, get medical advice if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, get immediate medical attention
Most Important Symptoms: Stomach discomfort, nausea, eye redness, respiratory irritation
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Strong water jet may spread material
Hazardous Combustion Products: Hydrogen chloride gas, nitrogen oxides, carbon oxides
Firefighter Protection: Use self-contained breathing apparatus, full protective firefighting clothing
Special Procedures: Evacuate area, cool containers with water, avoid inhaling combustion gases
Personal Precautions: Wear respiratory protection, chemical resistant gloves, safety goggles, avoid dust formation
Environmental Precautions: Prevent spill from reaching drains, surface water, or soil
Clean-up Methods: Use moistened absorbent material to collect spill, transfer to waste container, wash area with plenty of water afterward
Reference to Other Sections: See Disposal Considerations and Exposure Controls for additional information
Handling: Wear personal protective equipment, minimize dust generation, avoid inhaling and direct contact with material, wash hands after handling
Storage: Store in tightly closed container in cool, dry, well-ventilated area, keep away from incompatible substances such as oxidizers, acids, avoid light and moisture
Special Provisions: Keep out of reach of children, do not store near food or beverages
Occupational Exposure Limits: Not established for dapoxetine hydrochloride, general dust limit: 10 mg/m³ (total inhalable)
Engineering Controls: Local exhaust ventilation or use in fume hood
Personal Protective Equipment: Respiratory mask (NIOSH approved), nitrile gloves, laboratory coat, safety goggles or face shield
Hygiene Measures: Keep workplace clean, do not eat or drink while handling, wash thoroughly after handling
Appearance: White or off-white crystalline powder
Odor: Faint, medicinal
Odor Threshold: Not available
pH: 3.0–5.0 (1% solution in water)
Melting Point: 180–185°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Freely soluble in water, soluble in methanol, ethanol
Density: About 1.30 g/cm³
Vapor Pressure: Not available
Partition Coefficient (log Kow): 3.6
Flash Point: Not available
Auto-Ignition Temperature: Not available
Chemical Stability: Stable under recommended storage conditions, sensitive to strong light and moisture
Possibility of Hazardous Reactions: May react with strong oxidizing agents, acids, and bases
Conditions to Avoid: Direct sunlight, excessive heat, ignition sources
Materials to Avoid: Oxidizers, strong acids
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide and dioxide during thermal decomposition
Acute Toxicity: LD50 (oral, rat): Approx. 520 mg/kg
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Nausea, headache, drowsiness, dizziness, severe eye or skin irritation at high exposures
Chronic Effects: No data on carcinogenicity, mutagenicity, reproductive toxicity in humans; animal studies at high doses show possible nervous system effects
Other Effects: Not listed as a controlled substance or known sensitizer
Ecotoxicity: Potential acute toxicity to aquatic organisms based on pharmaceutical class
Persistence and Degradability: Expected to degrade slowly in the environment
Bioaccumulation: No significant bioaccumulation expected, log Kow indicates moderate potential
Mobility in Soil: May migrate through soil if released
Other Adverse Effects: Minimize release to the environment due to pharmaceutical activity
Waste Treatment Methods: Incineration at licensed chemical waste facility, do not release to sewer systems
Containers: Dispose of in compliance with local and national regulations, under supervision of licensed waste handlers
Precautions: Avoid dust generation during disposal, wear all recommended protective equipment, label containers clearly as pharmaceutical waste
UN Number: Not classified as hazardous for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not considered marine pollutant
Special Precautions: Ensure packaging prevents release during transit, follow shipment rules for pharmaceuticals if required
Safety, Health, and Environmental Regulations: Subject to monitoring as an active pharmaceutical ingredient
OSHA Status: Not classified as hazardous under OSHA Hazard Communication Standard
TSCA Status: Not listed in the TSCA inventory; handled under pharmaceutical controls
Other Regulations: Refer to national legislation regarding workplace exposure, workplace environmental release, and pharmaceutical controls
Labeling Requirements: Pharmaceutical-grade products require specialized labeling for use and disposal
