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Dapoxetine Hydrochloride: A Deeper Look at Its Path and Potential

Historical Development

Dapoxetine Hydrochloride did not emerge out of nowhere. Research teams in the late 20th century understood the growing need for better treatments in male sexual health, especially with premature ejaculation causing distress far beyond the bedroom. Most drugs targeting this condition relied on off-label antidepressants with questionable results and awkward side effects. Pharmaceutical companies started seeing the gap, and by the late 1990s, scientists brought new focus to SSRIs, investigating shorter-acting compounds. Dapoxetine stood out from the usual candidates because it did not linger in the system for days, which meant fewer ongoing effects and more practical control over timing. Patents followed, with clinical studies in the 2000s affirming what researchers suspected: taken a few hours before intercourse, dapoxetine delivered measurable improvement for millions living with dissatisfaction and shame. Now, with regulatory approvals spanning dozens of countries, a once-overlooked issue found relief rooted in sound chemistry.

Product Overview

Dapoxetine Hydrochloride current forms most often as a white or nearly white crystalline powder. Pharmacists and chemists appreciate the purity, as any sign of color changes or caking usually signals trouble with degradation or admixture. Tablets come in standard 30mg and 60mg doses, packaged to block light and moisture, since stability can take a hit if humidity creeps in. Each blister or bottle points to storage away from extremes, underlining that this compound is not built for rough handling. Off-the-shelf options include film-coated or plain compressed varieties, and these generally handle well in patient pouches, giving users discreet and reliable access. Labels spell out a simple, clear message: take with a full glass of water a couple of hours before sexual activity, and skip alcohol to dodge dizziness. In practice, that clarity saves more than a few unwanted surprises.

Physical & Chemical Properties

The appearance of dapoxetine hydrochloride draws on its crystalline, nearly white structure, signaling purity sought by everyone from production supervisors to a patient opening a foil strip. Its molecular formula, C21H23NO·HCl, reflects the fusion of a selective serotonin reuptake inhibitor core with hydrochloride, boosting solubility and absorption. With a molecular mass hovering near 341 grams per mole, it flows well in powder form but does not lend itself to rapid lumping, helping formulators avoid headaches during mixing. Water solubility matters directly to drug delivery. Dapoxetine hydrochloride sits comfortably on the scale, dissolving well enough to release steadily in the gut and provide a controlled, predictable rise in blood levels. It melts in the 175–179°C range, avoiding headaches in standard tablet manufacture, and stays stable under factory lighting, as long as humidity stays in check. Its chemistry fits well with the mainstream pharma toolkit.

Technical Specifications & Labeling

Strict standards rule dapoxetine hydrochloride’s world. Pharmacopeias set assay limits, rarely allowing more than 1% deviation from label claim, and related substance thresholds keep degradation peaks from rising too high in batch analysis. Residual solvents and heavy metals do not get a pass — regulatory authorities keep a sharp eye on these, with levels in finished batches usually an order of magnitude lower than allowed. Every batch record tells a story, demanding signatures not only from quality control but also from manufacturing leads. Labels warn against use with some antidepressants and caution liver or kidney patients, underscoring the need for sensible prescribing. Box warnings highlight dizziness and sudden drops in blood pressure if standing suddenly, handing patients a heads-up far too rare in older medicines. Clear pictograms guide daily use—no guesswork about what “as needed” means in this space.

Preparation Method

The synthesis of dapoxetine hydrochloride involves several fine-tuned steps, rooted in classical organic chemistry but modernized with automated reactors and advanced purification. Starting with commercially available naphthylamine, the process bends modern standards, forging the core structure through a Mannich-type reaction. N-alkylation, followed by ester hydrolysis and then reduction, yield intermediates that build dapoxetine’s backbone. The final coupling, with hydrochloric acid, delivers a stable salt, guaranteeing absorption levels needed for oral delivery. Each step runs under watchful eyes and regular spot-checks, where operators look for physical changes—crystal forms, residue, color—that might signal a problem. Solvent swaps and purification by recrystallization polish the final product, leaving a pharmaceutically clean, potent powder. Current methods find balance between process yield and environmental safety, as regulatory review pulls focus toward waste reduction and worker protection.

Chemical Reactions & Modifications

Dapoxetine’s structure lends itself to certain modifications. Small tweaks—like changes to the naphthyl group or variations in side-chain length—hold the potential for new properties, but change too much and positive effects fade or safety becomes a concern. Chemists explore derivatives for improved onset, longer duration, or altered selectivity for serotonin over other neurotransmitters, chasing fewer side effects and smoother absorption. Research highlights that esterification or amide formation can retain SSRIs’ core activity but tuning hydrophobicity or electron-donating groups sometimes makes all the difference between a good result and failure. Each modification gets a full run at pharmacokinetics and metabolic pathways, with teams testing for reactive metabolites that could linger in the liver or kidneys. The ability to adapt dapoxetine opens the door for not just new treatment options but also downstream drug discovery programs that step beyond sexual health into neurological or psychiatric care.

Synonyms & Product Names

Dapoxetine hydrochloride appears under multiple names, often depending on country or supplier. Common synonyms in chemical supply catalogs include N,N-dimethyl-(alpha)-(naphthalen-1-yl)phenylmethanamine hydrochloride, and in some texts, just “Priligy” refers to the best-known brand name worldwide. National generic versions fill pharmacy shelves under variations like “Joypox,” “Duratia,” and “Dapox,” each maintaining the same active ingredient. This spread helps cut through cost barriers, letting more patients experience equal relief without price gouging or counterfeit risks. Pharmacies and hospitals rely on lot numbers, batch codes, and origin certificates, helping track recalls and authenticity in an age where supply chains stretch across continents. Chemical literature and regulatory filings keep synonyms close at hand, as small differences sometimes suggest divergent impurities or production methods in global trade.

Safety & Operational Standards

Handling dapoxetine hydrochloride safely ranks as high as its finished activity. Manufacturing and packaging workers use gloves, masks, and ventilation, respecting the compound’s dust potential and the risk to eyes or airway. MSDS sheets provide detailed first aid and spill cleanup, highlighting water and powder absorption as standard practice for small incidents. Emergency plans aren’t theoretical either — companies hold regular drills, and processing equipment builds in fire prevention and spill containment. For users, package inserts flag the risk of syncope and serotonin syndrome, especially in combination with other drugs adjusting brain chemistry. Careful attention keeps patients safer, but much of the risk lies in honest consultation: users need to disclose other medications, health conditions, or even patterns like alcohol use. Physicians, pharmacists, and quality managers keep the conversation going about side effects, drug holidays, and signs of allergic reaction, steering the compound clear of the dangers plaguing less vetted alternatives.

Application Area

Dapoxetine hydrochloride found the bullseye treating premature ejaculation, but its role often touches broader aspects of men’s health and relationships. What’s easy to miss in statistics is the way sexual dysfunction chips away at confidence, communication, even work performance. Quick fixes or herbal alternatives rarely deliver more than placebo, and dapoxetine’s targeted use means men do not commit to indefinite medication just to manage a frustration lasting seconds. Some urologists and psychologists encourage its use as a “bridge therapy,” building confidence and helping couples break damaging cycles of self-blame. Telehealth and online pharmacy access now expand dapoxetine’s reach deep into rural or stigmatized communities, where direct access once seemed impossible. Research teams explore off-label uses, from helping with delayed ejaculation in patients on SSRIs to potentially reducing some forms of compulsive sexual behavior. The core goal never changes: restoring quality of life where silence too often reigns.

Research & Development

R&D teams never stop looking for improvements. Early efforts refined dosages and identified the crucial gap in metabolism between fast and slow acetylators—meaning one-size-fits-all rarely applies. Later studies broke ground linking dapoxetine’s rapid absorption to food intake, alcohol, and genetic traits, shifting clinical practice away from blanket recommendations. New work digs into combinations with behavioral therapy, where results linger past the drug's half-life. Animal trials and cell studies continue, digging at neurochemical changes beyond serotonin, hunting for clues to future approaches that may bypass dapoxetine altogether. Formulators test new tableting agents, chasing tablets that dissolve faster, resist humidity, or improve shelf life for pharmacies in tropical climates. The search for next-generation compounds led to patents for prodrugs, sustained-release matrices, and even sublingual options, each with its own hurdles but clear intent to let patients choose what fits their lives.

Toxicity Research

No new pharmaceutical product escapes rigorous toxicity tests, and dapoxetine hydrochloride stood under that same spotlight. Extensive animal studies marked out the thresholds for acute and chronic exposure, flagging doses where neurotoxicity or cardiovascular strain began to show. Researchers mapped out reproductive and developmental effects, as well as impacts on liver enzymes and kidney markers, keeping a sharp eye on subtle changes missed in early human trials. In people, monitoring tracked dizziness, sleep pattern shifts, and rare cardiac anomalies, especially in those mixing the drug with other SSRIs, MAOIs, or medical cannabis. Post-marketing surveillance keeps piling up new data points, showing most adverse reactions remain mild and reversible, provided users follow guidance. Unintentional overdoses or black-market misuse, especially where counterfeits crop up, remind everyone that safety depends as much on consistent supply and patient education as it does on chemical formula or dose.

Future Prospects

Demand for better, faster options in sexual health shows no sign of slowing. Companies and government health groups now look at dapoxetine hydrochloride not as an end in itself but as a stepping stone. Personalized medicine, driven by genetic screening or detailed metabolic mapping, opens the door to more tailored dosing and even new derivatives matched to individual patients. Digital health apps and wearable sensors track treatment outcomes in real time, gathering data clinicians once dreamed of only in trial settings. Broader mental health integration means physicians view dapoxetine in context—not as a band-aid but as one route among many for restoring healthy, rewarding lives. Environmental pressure nudges scientists to rethink synthesis and packaging, targeting greener solvents, less waste, and recycled packaging. Ultimately, dapoxetine’s story stands out: a product that listened to unmet needs, adapted fast to social change, and now sets the pace for what patients expect from modern medicine.




What is Dapoxetine Hydrochloride used for?

Looking at the Facts

Dapoxetine Hydrochloride is one of those medications that comes up whenever people talk about sexual health, especially for men struggling with premature ejaculation. For a long time, men didn’t talk about this issue much, despite it affecting relationship satisfaction and self-esteem. As someone who’s heard friends, patients, and doctors talk about the impact, it’s clear that seeking help makes a difference. A medication that addresses this specific concern gives men more control and restores confidence.

Understanding the Science

This drug works as a short-acting selective serotonin reuptake inhibitor (SSRI), which basically means it affects how nerves in the brain handle serotonin. Doctors usually use regular SSRIs to treat depression or anxiety, but dapoxetine acts faster and clears out sooner. This quick action makes it different—it isn’t meant for daily use over months, but rather taken before sex. Clinical studies show that dapoxetine extends the time before ejaculation for many men. In real life, that often means less frustration for both partners and more positive experiences in the bedroom.

Quality of Life and Social Connection

Sexual health goes beyond the physical act. Challenges like premature ejaculation have ripple effects on relationships. People may start avoiding intimacy, or feel embarrassed and alone. Many men struggle with shame or with the idea that their experience isn’t normal, which only makes things worse. Pharmacies in many countries started offering dapoxetine without much fuss after health regulators looked closely at its safety profile. This change helped men get help more discreetly, rather than hoping the problem would sort itself out. Research backs up its safety when used as prescribed, though users can face side effects like nausea, dizziness, or headaches. Balancing the benefits against the risks comes down to honest conversations with a doctor.

Addressing Misconceptions and Myths

There’s a lot of talk about “quick fixes” and miracle pills. Dapoxetine isn’t a magic solution. Lifestyle choices, mental health, and communication all matter. Relying only on medication can lead to disappointment if expectations aren’t realistic. Some men don’t respond to dapoxetine as hoped, or they experience side effects that outweigh any improvement. It’s also not for everyone—those with heart problems or a history of depression need careful screening.

Looking Forward: A More Open Conversation

The important takeaway is that sexual difficulties are common, and medical science can offer real help. Encouraging more open, stigma-free talk helps people feel supported and informed. Reliable information from organizations like the International Society for Sexual Medicine shows dapoxetine works for a lot of men who try it under medical guidance. Greater openness and honest dialogue can help more couples address sexual health issues head-on. No one should feel isolated by problems that modern medicine and healthy communication can help.

Building Solutions and Support

Doctors can help by making conversations about sexual health a regular part of check-ups. Pharmacists play a role by educating patients about side effects and how to use dapoxetine safely. Looking at the bigger picture, tackling the shame and silence surrounding men’s sexual health does just as much good as any pill on the shelf. Dapoxetine is a useful tool, but it works best as part of a broader approach that includes listening, education, and support.

How should Dapoxetine Hydrochloride be taken?

What Dapoxetine Hydrochloride Means for Men

Dapoxetine Hydrochloride stands on the pharmacy shelf offering hope to men struggling with premature ejaculation. Plenty of folks know the feeling—relationships strain, self-esteem tumbles, and frustration grows. A pill isn’t a magic wand, but it’s better than silent suffering and dodgy Internet “cures” that flood inboxes. Real, researched pharmaceuticals like dapoxetine can offer relief grounded in science, not wishful thinking.

Getting the Most from the Medicine

It takes more than swallowing a tablet to see the changes. Instructions from the doctor aren’t just for show—they keep bad side effects out of the picture and bring results. Each dose, usually 30mg or 60mg, enters the body quickly, so timing matters. Swallow one tablet with water about one to three hours before sex. Avoid doubling up if you skip a day, and don’t treat it like a daily supplement. The plan sets clear guardrails, helping users avoid misuse and accidents.

Personal Experience, Personal Responsibility

No two people have the same experience with medications. Some men tolerate dapoxetine smoothly, feeling only relief. Others notice headaches, dizziness, or mild nausea. Reading the warning leaflet or chatting with a real prescriber can clear up a lot of confusion. Never take more than one tablet in 24 hours, and always combine with food or a glass of water to keep stomach discomfort in check.

Alcohol and Other Drugs: Not a Good Mix

A big mistake: mixing dapoxetine and booze. Alcohol increases the risk of fainting or wooziness. The same red flag pops up with other medications—antidepressants, triptans for migraines, strong pain relievers. Drug interactions sit high on the list of what real healthcare professionals warn about. That’s why talking openly with a prescriber, pharmacist, or trusted doctor backs up every dose with safety.

Main Facts That Matter

Peer-reviewed research shows dapoxetine acts fast and flushes out of the body in less than a day. It doesn’t stick around for future encounters, so timing is crucial. Overdosing promises zero extra benefit and risks a parade of side effects. This drug only suits men who actually fit the medical definition of premature ejaculation, not anyone hunting for a performance boost without a clear diagnosis.

Safety, Trust, and Access

Buying something through a sketchy online site skips basic safety checks. Legitimate dapoxetine comes through licensed pharmacies, not pop-up ads. Honestly, getting medicine from sources that stand behind their product cuts fake pills, wrong dosages, and dangerous stowaways masquerading as real medicine. Trusting the healthcare system—or at the very least, a qualified local pharmacist—means peace of mind all the way.

Solutions to Make Use Safer

A brief, honest consultation before the first dose can reveal allergies, hidden medical issues, or drug clashes. Doctors don’t just scribble out a script; they catch the hidden risks. Following their advice, sticking to recommended amounts, and respecting those “do not drink” warnings all add layers of protection.

Looking Ahead

Using dapoxetine the right way means more than just treating a problem—it means investing in trust, partnership with your healthcare provider, and confidence in each step along the way.

What are the common side effects of Dapoxetine Hydrochloride?

Understanding Dapoxetine’s Impact on the Body

Dapoxetine hydrochloride appears on the scene for one main reason—treating premature ejaculation. Doctors usually suggest it for men who want to increase control over ejaculation and improve their overall experience. Many folks hear the name or see ads online but don’t always grasp what the pill can do to the body apart from its main purpose. It’s smart to have straight facts before starting any medication. Medications promising results often bring their own set of hurdles. Dapoxetine is no different.

Common Side Effects Men Should Watch Out For

After using Dapoxetine for the first time, some men mention feeling lightheadedness or nausea. That spinning sensation is tough to ignore and could catch you off guard, especially if you’re driving or working. Gastrointestinal symptoms show up a lot—people often report mild stomach discomfort along with nausea. Headaches are another thing to watch, affecting a good number of users. For some, these headaches can fade after a few doses; for others, they linger, affecting daily tasks.

Some users experience dry mouth. It may not sound serious, but feeling parched during an important meeting or even on a date can make your day harder. Insomnia has cropped up as well—folks describe difficulty falling or staying asleep, leaving many feeling groggy the next day. Taking the pill too late in the evening seems to make those sleep issues worse. Sweating more than usual is another side effect, often noticed during routine things like walking upstairs or being outside in mild weather.

Less Talked About Reactions

Fatigue and dizziness often go hand-in-hand and can sneak up. If you’re already tired from work or family demands, suddenly adding a medication that increases fatigue will leave you out of sorts. Anxiety isn’t uncommon, either; some users share that their mood takes a hit or they feel more on edge. Diarrhea has been documented too. That may not be the first thing you mention to your doctor, but it’s a common enough issue to keep in mind if you’re planning travel or long days out.

Losing interest in sex or feeling less pleasure is not unheard of, in a surprising twist for a drug aimed at sexual improvement. Heart palpitations have also come up. Anybody with a heart history or family risk factors should mention those details to their healthcare provider. These less common reactions might sound rare, but my experience as someone around friends and family on various medications says never brush off the unexpected. Your doctor needs the full picture.

Why Not All Side Effects Get Talked About

Online forums and real-world conversations behind closed doors show that not everyone talks openly about side effects. Embarrassment, fear of judgment, or just hoping things will get better on their own keep many men silent. The FDA and European Medicines Agency list these issues among the most reported, so if you feel something’s off, you’re not alone. Brand promotions often focus on success stories, not the rough patches. Everyone’s body is different, so your reaction might be milder or more intense than someone else’s. Always touch base with a healthcare provider after starting something new, especially if you have any medical conditions or take other medications. No over-the-counter “solution” or “herbal fix” matches the safety of doctor-guided care.

Moving Forward Safely

Clear conversations with healthcare providers make all the difference. Honest reporting keeps you safer and also helps doctors get a real-world sense of how patients feel on this medication. Starting a new drug often feels like a leap. Dapoxetine gives hope to many, but knowing the full story makes people more likely to use it carefully and get the best outcome possible.

Can Dapoxetine Hydrochloride be taken with other medications?

Understanding Dapoxetine Hydrochloride

Dapoxetine Hydrochloride stands out as a prescription medication for treating premature ejaculation in adult men. Doctors usually recommend it for those looking to improve their control over ejaculation and lessen any distress connected to the condition. Since it acts as a selective serotonin reuptake inhibitor (SSRI), the way Dapoxetine works in the body holds similarities to antidepressants, even though it's not meant for depression.

The Reality of Taking Multiple Medications

Many people don’t just take one pill to solve one problem. Life brings complicated health challenges, and the medicine cabinet reflects that. Stomach ulcers, blood pressure, diabetes, allergies—these issues often require daily management. Taking Dapoxetine alongside other drugs can seem easy, but there’s more to the story.

Mixing medications often raises important questions. Will one drug reduce the effect of another? Could the combo bring up new side effects—or make existing ones worse? These aren’t just concerns for scientists. Anyone who’s juggled two or three prescriptions at once has probably wondered about these risks.

What Science Says About Dapoxetine Interactions

Dapoxetine doesn’t interact safely with every medication. Researchers found that taking it with certain antidepressants, especially monoamine oxidase inhibitors or other SSRIs, can boost levels of serotonin in the brain beyond what’s safe. This situation sometimes leads to serotonin syndrome—a condition that can bring confusion, muscle twitching, fever, and serious heart issues. That’s not a risk to take lightly.

People who rely on medications for high blood pressure or heart health also face concerns. Dapoxetine can drop blood pressure, especially after standing up. If a patient already takes drugs called nitrates—often prescribed for chest pain or heart disease—combining them with Dapoxetine increases the risk of severe low blood pressure.

Antifungals like ketoconazole and certain antibiotics such as erythromycin don’t mix well with Dapoxetine either. These drugs slow the breakdown of Dapoxetine in the body, which means higher blood levels and stronger side effects. Alcohol often gets ignored in these conversations, but mixing it with Dapoxetine commonly triggers dizziness or fainting.

Finding Safe Paths Forward

Drug interactions become less of a mystery with the right information and honest conversations. Before starting Dapoxetine, talk with a doctor or trained pharmacist. Tell them about every medication and supplement in use. Those details help avoid surprises and keep treatment plans safe.

Manufacturers warn against combining Dapoxetine with some medications. But every person brings a different set of health problems and prescription lists. Doctors use published research and detailed drug databases to sort out risks and benefits. Routine check-ups, blood pressure monitoring, and asking about new symptoms play a big part in staying healthy.

Being upfront about alcohol use and over-the-counter products adds another layer of safety. With new medications, even small changes in daily routine count. Instead of rushing to add Dapoxetine into the mix alone, reach out to a healthcare provider for tailored advice.

Managing sexual health matters just as much as blood sugar or heart rate. With responsible guidance and honest dialogue, men who need Dapoxetine can reduce risk and improve quality of life without unwanted setbacks.

Is Dapoxetine Hydrochloride safe for everyone to use?

What is Dapoxetine Hydrochloride and Why Do People Use It?

Plenty of men with premature ejaculation look for ways to improve their experience in the bedroom, and Dapoxetine Hydrochloride comes up a lot. The drug acts as a selective serotonin reuptake inhibitor (SSRI) and promises to delay ejaculation. Some men feel a real boost in confidence after using it, and doctors in many countries prescribe it specifically for this issue. People hoping for better control can get immediate results, but the journey doesn’t always end with just a prescription and a handshake.

Who Might Face Trouble Using Dapoxetine?

Many believe a pill can easily solve this kind of problem, but stories from clinics and patient reviews tell a mixed tale. Some men go through nausea, headaches, or feeling dizzy. Severe side effects like fainting or irregular heartbeat come up too, mostly in those with heart conditions or people mixing drugs without telling their doctor. Not everyone reads the warnings or admits to drinking alcohol before taking the pill, which can ramp up risks. The FDA and European Medicines Agency both suggest avoiding this drug if you already deal with heart rhythm disorders or take certain antidepressants. Taking multiple drugs that affect the brain and heart together puts anyone in a dangerous spot.

Shortcuts Don’t Work With Health

Friends sometimes trade packs or buy online to skip the embarrassment of seeing a doctor. This approach skips any check for hidden problems—like liver or kidney issues—that make the drug risky. I spoke with a pharmacist once who had to turn away men asking for the pill after they rattled off a list of other medications. He worried about serotonin syndrome, a rare but dangerous overload of serotonin in the brain from drug interactions. Those selling the drug without a doctor’s advice usually won’t warn about this.

What Makes a Drug Safe for Someone?

Safety isn’t just about statistics. Doctors can look at evidence, but no single study covers everyone’s real life. Age, health, mental state, and existing conditions all matter. Older men and those living with depression might run into trouble quicker than younger, healthy guys. Researchers in India found that over 20% of men in a trial stopped the drug because side effects got in the way. Personal stories reveal side effects sometimes don’t show up for weeks, adding more uncertainty to the mix. It becomes clear: talking with a doctor who knows your history beats any one-size-fits-all answer.

How Can Men Take Fewer Risks?

It’s tempting to look for quick solutions, but missing the big picture causes more harm than good. Checking labels, avoiding alcohol, and talking with a healthcare provider keep risks down. Regular check-ins can spot problems before they get dangerous. Some doctors also recommend therapy or counseling, especially for those whose anxiety about performance makes everything worse. Combining physical and mental health care protects both body and relationships.

Moving Beyond One Pill for One Problem

The stories from users, doctors, and researchers keep pointing back to the same lesson—medications like Dapoxetine Hydrochloride need medical supervision. What works well for one person might spell trouble for another unless someone keeps an eye out for side effects and interactions. Every decision about health deserves honesty, care, and a willingness to look past advertising. A real solution grows from teamwork between a patient and their doctor, not a single pill pulled from a box.

Dapoxetine Hydrochloride
Names
Preferred IUPAC name (+-)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propan-1-amine hydrochloride
Other names Priligy
Westoxetin
Dapoxetina
Dapoxetin
Dapoksetin
Dapoxetine HCl
Pronunciation /dəˈpɒksətiːn haɪˌdrɒklaɪˈraɪd/
Identifiers
CAS Number 129938-20-1
3D model (JSmol) `3D model (JSmol)` string for **Dapoxetine Hydrochloride**: ``` [H][C@@]1(CN(CC2=CC=CC=C2)CCC3=CC=CC=C13)CN(C)C.Cl ```
Beilstein Reference 3929824
ChEBI CHEBI:79015
ChEMBL CHEMBL1200988
ChemSpider 21545161
DrugBank DB04884
ECHA InfoCard 100.224.305
EC Number 670411-58-8
Gmelin Reference 14750248
KEGG D06065
MeSH Dapoxetine Hydrochloride"[MeSH]
PubChem CID 71387274
RTECS number GU05BVN94A
UNII 1M7CYN4Y3D
UN number UN2811
CompTox Dashboard (EPA) DTXSID6052992
Properties
Chemical formula C21H24NO•HCl
Molar mass 372.88 g/mol
Appearance White or almost white powder
Odor Odorless
Density Dapoxetine Hydrochloride has a density of 1.22 g/cm³
Solubility in water Freely soluble in water
log P 2.9
Acidity (pKa) 9.75
Basicity (pKb) 2.84
Magnetic susceptibility (χ) -49.5·10⁻⁶ cm³/mol
Refractive index (nD) 1.576
Viscosity Viscous liquid
Dipole moment 3.87 D
Thermochemistry
Std molar entropy (S⦵298) 390.65 J·mol⁻¹·K⁻¹
Pharmacology
ATC code G04BX14
Hazards
Main hazards Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation.
GHS labelling GHS02, GHS07
Pictograms GHS07
Signal word Danger
Hazard statements H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
Precautionary statements Keep out of reach of children. Read label before use. If medical advice is needed, have product container or label at hand.
Flash point > Flash point: **273.6°C**
Lethal dose or concentration Lethal dose or concentration (LD50; oral, rat): 2231 mg/kg
LD50 (median dose) 196.2 mg/kg (Rat, oral)
NIOSH
PEL (Permissible) PEL (Permissible) for Dapoxetine Hydrochloride: Not established
REL (Recommended) 30 mg as needed
IDLH (Immediate danger) Not listed
Related compounds
Related compounds Duloxetine
Fluoxetine
Nisoxetine
Atomoxetine
Reboxetine
Venlafaxine
Milnacipran