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Product Name: Danofloxacin Mesylate
Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, methanesulfonate salt
Synonyms: Danofloxacin Monomethanesulfonate
CAS Number: 123353-62-2
Recommended Use: Veterinary antibiotic
Manufacturer Contact: Emergency phone available through supplier on product packaging
Product Description: Pale yellow to light yellow crystalline powder
Classification: Harmful if swallowed, causes eye and skin irritation, may cause respiratory irritation
Hazard Statements: May be toxic to aquatic life with long-lasting effects, avoid inhalation and contact with skin and eyes
Signal Word: Warning
Pictograms: Exclamation mark, aquatic toxicity symbol
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use only in well-ventilated areas
Emergency Overview: Powder may form explosive mixtures with air, fire or explosion risk if dust is dispersed
Chemical Identity: Danofloxacin Mesylate
Concentration: 98–100% (active ingredient)
Impurities: Not detected above 1% threshold
Molecular Formula: C19H20FN3O3·CH4O3S
Molecular Weight: Approximately 479.53 g/mol
Relevant Impurities: None expected under normal manufacturing specifications
Inhalation: Move person outdoors, keep at rest, seek medical attention if symptoms occur
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, consult physician for persistent irritation
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if possible, seek medical help promptly
Ingestion: Rinse mouth with water, do not induce vomiting, call a medical professional for guidance
Important Symptoms and Effects: Respiratory irritation, coughing, sore throat, skin and eye redness, gastrointestinal discomfort possible if ingested
Medical Attention and Special Treatment: Symptom-oriented supportive care recommended
Suitable Extinguishing Media: Water spray, carbon dioxide, foam, dry chemical extinguishers can suppress fire
Unsuitable Extinguishing Media: Avoid strong water jets that may disperse powder dust
Hazards Arising from Combustion: Releases carbon oxides, nitrogen oxides, sulfur oxides, toxic fluorine compounds
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Firefighting Procedures: Keep containers cool by spraying with water, prevent run-off from reaching waterways or drains
Personal Precautions: Evacuate area, wear protective clothing, gloves, goggles, avoid dust formation, ensure adequate ventilation
Environmental Precautions: Prevent product from entering drains, watercourses, soil; report environmental release as legally required
Cleanup Methods: Sweep or vacuum up without creating airborne dust, transfer into waste containers, wash spill site with water after removal
Containment: Dike area to contain large spills, seal containers for disposal, avoid raising dust clouds
Handling: Handle in a controlled environment, use local exhaust ventilation, wear PPE, avoid contact with skin, eyes, and clothing, do not eat, drink or smoke while handling
Storage: Store tightly closed in original packaging, cool dry place away from incompatible materials, protect from light, keep away from food and beverages
Incompatible Materials: Strong oxidizing agents, strong acids or bases, sources of ignition or extreme heat
Special Requirements: Keep container upright, secure area against unauthorized access
Occupational Exposure Limits: No established national occupational exposure limits; minimize exposure as much as possible
Engineering Controls: Use process enclosures, exhaust ventilation to maintain airborne concentrations below recommended limits
Personal Protective Equipment: Chemical-resistant gloves (nitrile or latex), safety goggles or face shield, lab coat or protective gown, approved respirator for dusts if ventilation insufficient
Hygiene Measures: Wash hands, face thoroughly after handling, remove contaminated clothing and wash before reuse
Appearance: Pale yellow to light yellow crystalline powder
Odor: Slight, not distinctive
Odor Threshold: Not established
pH: 2-4 (aqueous solution)
Melting Point/Freezing Point: Approximately 217–220°C
Boiling Point: Not available (decomposes before boiling)
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: No data on flammability but organic powders can ignite under certain conditions
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density: 1.42 g/cm3
Solubility: Freely soluble in water
Partition Coefficient (n-octanol/water): Log Kow = -0.9 (estimated)
Auto-ignition Temperature: Not available
Decomposition Temperature: Above 220°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions, sensitive to light and moisture
Reactivity: Non-reactive under normal handling,
Possibility of Hazardous Reactions: Dust-air mixtures may ignite/explode, avoid static discharge
Conditions to Avoid: Exposure to heat, ignition sources, incompatible substances
Incompatible Materials: Avoid contact with strong oxidizers, acids, alkalis
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen, sulfur compounds, oxides of fluorine
Acute Toxicity (oral): LD50 (rat) ~1000 mg/kg
Acute Toxicity (inhalation): No data available; considered harmful if dust inhaled in large amounts
Skin Corrosion/Irritation: May cause mild skin irritation, more severe if prolonged contact
Serious Eye Damage/Irritation: Causes moderate to severe irritation
Respiratory Sensitization: May cause allergy-like respiratory response in some sensitive individuals
Germ Cell Mutagenicity: No positive results in standard mutagenicity screens
Carcinogenicity: No evidence in animal studies
Reproductive Toxicity: Possible negative effects on fetal development at high doses in animal studies
Target Organ Effects: Elevated liver enzymes, kidney or gastrointestinal disturbances at high exposure
Other Toxicological Information: May cause nausea, headache, allergic-type skin rashes
Ecotoxicity: Toxic to freshwater and marine organisms, algae, crustaceans
Aquatic Toxicity: LC50 (fish, 96 hr): below 5 mg/L
Persistence and Degradability: Biodegrades slowly in soil and water; risk for accumulation in sediments
Bioaccumulation Potential: Limited, based on low partition coefficient
Mobility in Soil: Moderately mobile; risk for leaching to water supplies if released
Other Adverse Effects: Antibiotic activity can disrupt natural microbial balance in soils, aquatic environments, encourage resistance
Waste Treatment Methods: Treat as hazardous chemical waste, consult local, regional and national regulations before disposal
Disposal of Product: Incinerate in accordance with legal requirements, do not discharge to drains, watercourses, or environment
Contaminated Packaging: Triple rinse, puncture and send to licensed disposal facility
Special Precautions: Avoid dust release during disposal operations, wear PPE, handle by trained personnel
UN Number: Not regulated as a hazardous material for transport
UN Proper Shipping Name: None assigned
Transport Hazard Class: Not classified for land/sea/air transit
Packing Group: Not applicable
Environmental Hazards: Product may be hazardous to aquatic environment during bulk transport; follow best practice for containment
Transport Precautions: Ship in sealed containers, protect from physical damage and moisture
Labelling Requirements: Product carries warning symbols under GHS/CLP and OSHA standards
Chemical Inventory Status: Present on major inventories including TSCA, EINECS, DSL, AICS
Specific Regulations: Subject to prescription control for veterinary use in many regions
OSHA Hazard Status: Regulated as hazardous due to acute toxicity, irritation, environmental dangers
RCRA Status: Not listed as hazardous waste, handle as chemical waste
SARA Title III: Not subject to specific reporting requirements
Other Information: European regulations restrict use to authorized personnel, REACH registration exemption due to medicinal use
