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Product Name: D-Amino Acid Oxidase
Synonyms: DAO, DAAO, D-Aminoacid:oxygen oxidoreductase
CAS Number: 9001-37-0
Recommended Use: Research and laboratory reagent
Supplier Details: See label and purchasing documentation for contact information
Emergency Contact Number: Refer to local, national, or company guidelines and the product label
Classification: Non-hazardous under Globally Harmonized System guidelines, though proteinaceous material may present allergy risk through inhalation or contact in sensitive individuals
Signal Word: None
Hazard Statements: May cause mild irritation to skin, eyes, and mucous membranes in the case of direct, prolonged, or repeated exposure; low toxicity if ingested in small experimental amounts
Precautionary Statement: Avoid creating or inhaling aerosol or dust; avoid eye and prolonged skin contact; practice regular hygiene after handling
Chemical Name: D-Amino Acid Oxidase
CAS Number: 9001-37-0
Formulation: Typically supplied as a lyophilized powder or in aqueous buffer solution, containing stabilizers and trace preservatives such as sodium azide below 0.1% if present
Purity: Ranges from 90% to >98% as tested by activity assay
Impurities: Host cell proteins, buffer components
Inhalation: Move to fresh air if aerosol or dust inhalation occurs; seek medical advice if any symptoms such as coughing or irritation persist
Skin Contact: Wash affected area thoroughly with soap and water; remove contaminated clothing; seek attention if redness, itching, or irritation develops
Eye Contact: Rinse cautiously with water for at least 15 minutes, holding eyelids open; remove contact lenses if present and easy to do; obtain medical attention for persistent irritation
Ingestion: Rinse mouth with water; seek medical attention if discomfort or symptoms arise or large quantities are swallowed
Notes for Physician: Treat symptomatically; allergic reaction may require supportive measures
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Hazards from Combustion Products: May produce carbon oxides, nitrogen oxides, and other irritating gases under fire conditions
Special Protective Equipment: Firefighters must wear approved self-contained breathing apparatus and full protective gear to prevent respiratory exposure
Advice for Firefighters: Use water spray to cool containers, do not allow extinguishing water to enter drains
Personal Precautions: Wear appropriate protective equipment—gloves, goggles, laboratory coat or coveralls
Environmental Precautions: Do not allow product to reach soil, waterways, or drainage system; prevent further leakage if safe
Methods for Clean-Up: Absorb spill with inert material such as sand or vermiculite; wipe residues with a damp cloth; bag all contaminated materials for proper disposal; wash area with soap and water
Procedure for Large Spills: Contain spill, evacuate area as needed, ventilate, and use non-sparking tools
Disposal: See section on Disposal Considerations; handle precipitates as chemical waste
Safe Handling: Manage in accordance with laboratory safety protocols; minimize handling of dry powder to reduce risk of dust; avoid ingestion, inhalation, and contact with skin or eyes; proper training recommended for personnel
Storage Conditions: Store at recommended temperature, typically -20°C or below for solid/powder, or as indicated on product label for solutions; keep container tightly closed in a well-ventilated, dry environment away from moisture, incompatible materials, and oxidizing agents
Hygiene Practices: Wash hands thoroughly after handling; avoid eating, drinking, or smoking around the material
Engineering Controls: Use in areas equipped with local exhaust ventilation or fume hoods; minimize aerosol generation
Personal Protective Equipment:
Appearance: White to off-white lyophilized powder or clear to slightly opalescent solution
Odor: Odorless
Odor Threshold: Data not available
pH (for solution): Neutral to slightly alkaline (pH 7–9) in buffer
Melting Point/Freezing Point: Not applicable for enzyme powder; degrades with heat
Boiling Point: Not applicable
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Not available
Solubility in Water: Soluble
Partition Coefficient: Not available
Auto-ignition Temperature: Not data available
Decomposition Temperature: Begins degradation above 50°C
Molecular Weight: Typically 39–45 kDa depending on source/species
Chemical Stability: Stable under recommended storage conditions; slowly loses activity at ambient temperature, rapidly at elevated temperature
Reactivity: No dangerous reactions known under normal use
Conditions to Avoid: Exposure to heat, direct sunlight, moisture, acids and oxidizing agents
Incompatible Materials: Strong oxidizers, strong acids, metal ions that can denature proteins
Hazardous Decomposition: Produces carbon oxides, nitrogen oxides, or other gases at high temperatures; potentially denatured protein fragments
Acute Toxicity: No acute toxicity data for enzyme itself; expected to be low based on protein nature and past lab experience
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: May cause mild irritation to airways, skin, eyes; may pose allergy risk to sensitized individuals
Chronic Effects: No chronic toxicity identified in available literature; enzyme allergies may develop on repeated contact in sensitized persons
Carcinogenicity: No evidence for enzyme being carcinogenic
Mutagenicity and Reproductive Toxicity: No data available supporting genetic or reproductive effects
Sensitization: As with all proteins, repeated exposure carries risk of developing allergic response
Ecotoxicity: Not expected to harm aquatic life at low concentrations; contains biodegradable protein
Persistence and Degradability: Enzyme degrades naturally in soil and water through microbial action
Bioaccumulative Potential: Bioaccumulation unlikely
Mobility in Soil: Expected to have limited mobility
Other Adverse Effects: Dilute solutions and small spills are unlikely to result in environmental impact; presence of preservatives like sodium azide in some formulations may present localized toxicity, requiring dilution and careful disposal
Waste Treatment Methods: Dispose of via licensed chemical disposal contractor; treat residues as laboratory chemical waste
Product Disposal: Small quantities may be flushed with copious water if regulations allow; larger quantities require collection in clearly labelled containers and incineration or landfill at authorized facility
Contaminated Packaging: Rinse containers before disposal; dispose of in accordance with local and national laws
Environmental Precautions: Prevent undiluted spills from entering sewers, waterways, or soil to avoid potential harm; inactivate enzyme with appropriate chemical or heat treatment if necessary before disposal
UN Number: Not regulated
UN Proper Shipping Name: Not classified as dangerous goods for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Maintain cold chain if product requires refrigeration or freezing; secure packaging against breakage and leaks
Transport Documentation: Provide identification and contact details on all shipping documents
US Regulations: Not listed on major hazardous substance lists; subject to standard workplace safety regulations
EU Regulations: Not classified as hazardous under CLP Regulation (EC) No 1272/2008; packaging must comply with requirements for chemical products
Other National Regulations: Product use as research chemical only; not for food, drug, or household use
International Inventories: Not subject to special reporting or notification; confirm compliance according to destination regulations
Workplace Exposure Limits: No specific legal exposure limits assigned; apply general dust and biohazard controls as standard
