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Material Safety Data Sheet: Cystamine Dihydrochloride

Identification

Product Name: Cystamine Dihydrochloride
Chemical Name: 2,2'-Dithiobis(ethylamine) dihydrochloride
Synonyms: 1,2-Ethanediamine, N,N'-dithio-; Cystamine dihydrochloride; Bis(2-aminoethyl) disulfide dihydrochloride
CAS Number: 56-17-7
EC Number: 200-260-0
Recommended Use: Biochemical research, cross-linking agent, pharmaceutical intermediate
Supplier: Chemical manufacturing or laboratory supply companies
Contact Information: Provided on supplier label or website
Emergency Phone Number: As displayed on product label and company communications

Hazard Identification

Classification: Harmful if swallowed or inhaled, skin and eye irritant
GHS Label Elements: Warning symbol (exclamation mark), Signal word: Warning
Hazard Statements: H302: Harmful if swallowed; H332: Harmful if inhaled; H315: Causes skin irritation; H319: Causes serious eye irritation
Precautionary Statements: Wash hands thoroughly after handling, Avoid breathing dust, fumes, or vapors, Wear protective gloves and eye protection, Use only outdoors or in well-ventilated area
Potential Health Effects: Eye contact may cause redness and pain; skin contact can lead to irritation; inhalation of dust causes respiratory tract discomfort; ingestion may result in nausea or vomiting, central nervous system symptoms possible in severe cases
Environmental Hazards: Not expected to cause long-term adverse effects in the aquatic environment in typical laboratory use but still release to environment should be minimized

Composition / Information on Ingredients

Chemical Identity: Cystamine Dihydrochloride
CAS Number: 56-17-7
EC Number: 200-260-0
Purity: Greater than 98% (typically found in laboratory-grade chemicals)
Formula: C4H14Cl2N2S2
Molecular Weight: 223.21 g/mol
Impurities: No major hazardous impurities specified in standard laboratory supply; for specific batches, refer to the supplier certificate of analysis

First Aid Measures

Inhalation: Move individual to fresh air, keep person at rest in a position comfortable for breathing, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water, wash thoroughly with soap and water, seek medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, obtain medical advice if irritation continues
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical attention immediately, give water to drink if person is fully conscious
Most Important Symptoms: May include irritation to affected area, nausea, or drowsiness if large amounts are ingested
Advice for Medical Responders: Treat supportive and symptomatically, provide oxygen if breathing is difficult

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards: Combustion may produce irritating or toxic gases including ammonia, nitrogen oxides, sulfur oxides, hydrochloric acid vapors
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear to prevent contact with skin and eyes
Fire Fighting Instructions: Approach fire from upwind to avoid hazardous vapors and decomposition products, cool exposed containers with water spray

Accidental Release Measures

Personal Precautions: Evacuate area, use personal protective equipment including gloves, goggles, and laboratory coat, avoid dust formation
Environmental Precautions: Prevent further leakage or spillage, avoid entering drains or water courses, notify authorities if substantial release occurred
Methods for Clean-Up: Sweep up or vacuum material, place in suitable, labeled containers for disposal, ventilate area, wash spill site with water after material pick-up is complete

Handling and Storage

Handling: Work in a well-ventilated area, avoid dust generation, minimize direct contact with substance, wash hands after handling, avoid eating or drinking in workplace
Storage: Store in tightly closed container, keep in a cool, dry, well-ventilated location, keep away from incompatible materials such as strong oxidants and acids, protect from light and moisture, label all storage containers clearly

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific OSHA or ACGIH exposure limit established; treat as potentially hazardous substance
Engineering Controls: Use local exhaust ventilation, fume hood, or process enclosure where dust is generated, maintain eyewash stations and safety showers nearby
Personal Protective Equipment: Protective gloves rated for chemicals, safety goggles or face shield, lab coat or coveralls, NIOSH approved respirator recommended if dust or aerosols form
General Hygiene Practices: Remove contaminated clothing and wash before reuse, avoid using contact lenses without proper eye protection

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless or faint amine odor
pH (5% Solution): 4-6
Boiling Point: Decomposes before boiling
Melting Point: 220-230°C (decomposition occurs)
Solubility: Soluble in water
Vapor Pressure: Negligible at room temperature
Relative Density: 1.45 g/cm³ (approximate)
Partition Coefficient (n-octanol/water): No data available
Flash Point: Not flammable under typical conditions
Auto-ignition Temperature: No data available
Evaporation Rate: Not expected to be significant

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Excessive heat, moisture, direct sunlight; avoid dust generation
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Hazardous Decomposition Products: Hydrogen chloride, sulfur oxides, nitrogen oxides, ammonia, and carbon monoxide may form in fire or on decomposition
Polymerization: Will not occur under normal conditions

Toxicological Information

Acute Toxicity: Oral LD50 (rat): 910 mg/kg; inhalation effects studied in animals show irritation; skin and eye irritation observed in standard animal tests
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Immediate Effects: Respiratory tract and mucous membrane irritation, possible central nervous system effects if large doses involved
Delayed/Chronic Effects: Prolonged or repeated contact may cause dermatitis or eczema, data on mutagenicity and carcinogenicity is insufficient
Sensitization: Cases of allergic skin reaction reported with similar compounds
Other Data: Not listed by NTP, IARC, or OSHA as a known carcinogen

Ecological Information

Ecotoxicity: Expected to be of low toxicity to aquatic organisms, no acute toxicity data available for fish; at high concentrations, could contribute to nutrient loading
Persistence and Degradability: Not readily biodegradable; may persist in aquatic or soil environments
Bioaccumulative Potential: Low potential based on molecular structure but no measured BCF data available
Mobility in Soil: Soluble in water, may migrate through soil to groundwater in cases of significant spill
Other Adverse Effects: Avoid release into waterways to prevent local contamination

Disposal Considerations

Disposal Methods: Place contaminated material into containers approved for chemical waste, incinerate at approved facility or dispose of using local or national hazardous waste regulations
Handling of Empty Containers: Empty packaging or containers may retain residues, handle as hazardous material, do not re-use without proper cleaning
Environmental Precautions: Do not discharge into drains, soil, or watercourses; notify environmental authorities if accidental discharge occurs

Transport Information

UN Number: Not classified under United Nations transport regulations for dangerous goods
Transport Hazard Class: Not regulated as a hazardous material by US DOT, ADR, IATA, or IMDG
Packing Group: Not applicable
Labeling Requirements: Standard chemical label with hazard pictograms, ensure packaging prevents leaks or dust
Special Precautions: Secure packaging, protect from moisture, keep away from incompatible materials in transit

Regulatory Information

TSCA Status: Listed on US Toxic Substances Control Act Inventory
REACH Status: Registered or pre-registered under European REACH regulations
SARA Title III (Sections 302/313): Not listed as an extremely hazardous substance
California Proposition 65: Not listed as causing cancer, birth defects, or reproductive harm
Workplace Classification: Handle as hazardous chemical based on potential for skin, eye, or respiratory tract irritation
WHMIS Classification (Canada): D2B (Toxic Material Causing Other Toxic Effects)
Other Local Requirements: Follow all applicable federal, state/province, and local regulations for handling hazardous substances, keep hazard communication program up to date in workplace