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Product Name: Cyproheptadine Hydrochloride / Cyproheptadine Hydrochloride Hemihydrate
Chemical Formula: C21H21ClN2 / C21H21ClN2·0.5H2O
Chemical Family: Piperidine derivative antihistamine
CAS Number: 969-33-5 (Cyproheptadine Hydrochloride), 8003-49-0 (Hemihydrate variant)
Intended Use: Pharmaceutical active ingredient and research chemical
Manufacturer/Supplier Information: Detailed supplier and emergency contact information provided upon commercial transaction due to privacy and regulatory policies in the chemical industry.
GHS Classification: Acute Toxicity (Oral) – Category 4; Specific Target Organ Toxicity, Single Exposure – Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Can cause drowsiness, dizziness, and, in rare overdose, agitation, delirium, and convulsions
Precautionary Statements: Wear eye and face protection; avoid contact with skin and ingestion; work in well-ventilated space to reduce inhalation risks
Component: Cyproheptadine Hydrochloride (≥98% pure) / Cyproheptadine Hydrochloride Hemihydrate (≥97% pure)
Impurities: Trace organic synthesis and residual solvents present at less than 0.2% weight/weight; water content approximately 2.5% for hemihydrate version
Form: White to off-white crystalline powder for both variants; odorless, slightly bitter taste
Inhalation: Remove person to fresh air; seek immediate medical attention if persistent respiratory symptoms like coughing or wheezing occur
Skin Contact: Wash with plenty of running water and mild soap; remove contaminated clothing and shoes; consult physician in case of irritation or chemical burn
Eye Contact: Rinse cautiously with clean water for 15 minutes while keeping eyelids open; seek specialist advice, especially if irritation persists
Ingestion: Do not induce vomiting unless instructed by medical professional; rinse mouth with water; contact poison control and transport patient to emergency care for monitoring
Extinguishing Media: Water spray, dry powder, foam, or carbon dioxide can suppress flames
Specific Hazards: Decomposition releases toxic gases like hydrogen chloride, nitrogen oxides, and possible carbon monoxide
Protective Equipment: Firefighters require self-contained breathing apparatus and chemical-resistant clothing due to risk of inhaling harmful decomposition fumes
Personal Precautions: Evacuate all unprotected personnel from area; don chemical-resistant gloves, safety goggles, and mask
Environmental Precautions: Keep substance from entering water sources or sewer systems; collect using methods that prevent airborne dust (e.g., dampening with water, using HEPA-filtered vacuum)
Cleanup Methods: Carefully sweep up residue into a suitable labeled container for proper disposal by licensed waste handler; ventilate affected room
Handling: Use under efficient laboratory fume hood or extraction system; avoid generating airborne dust; always employ PPE including gloves, lab coat, eye protection
Storage: Keep in original, tightly sealed packaging away from incompatible chemicals like strong oxidizers and acids; store at room temperature (15–25°C), out of direct sunlight, in a dry, ventilated spot; keep away from food, beverages, and animal feed
Engineering Controls: Local exhaust ventilation, laboratory fume hood recommended
Respiratory Protection: Certified particulate respirator (N95/P2 or better) if handling large amounts or working where dust forms
Eye/Face Protection: Chemical safety goggles or face shield
Skin Protection: Rubber or nitrile gloves, chemical-resistant protective clothing
General Hygiene: Change contaminated clothing and wash hands before eating, drinking, or smoking to avoid accidental ingestion or skin contamination
Appearance: Fine white to off-white crystalline powder
Odor: Practically odorless
pH (1% solution): 4.0–6.0
Melting Point: 245–249°C (decomposes before boiling)
Solubility: Freely soluble in water and alcohol, practically insoluble in ether
Partition Coefficient: logP approximately 3.2 at neutral pH
Vapor Pressure: Not volatile under ambient conditions
Chemical Stability: Stable under normal storage and handling practices
Reactive Risks: Incompatible with strong oxidants, strong acids
Decomposition Products: Hazardous gases including hydrogen chloride, carbon monoxide, and nitrogen oxides produced under fire or pyrolysis
Polymerization: Not known to occur during recommended use and storage conditions
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: Drowsiness, agitation, confusion, tachycardia, blurred vision in case of overdose; otherwise therapeutic doses tolerated in adults as prescribed
Chronic Effects: Extended exposure or higher than prescribed dosing linked to anticholinergic syndrome, dry mouth, urinary retention
Carcinogenicity: No clear evidence from human or animal data for carcinogenic potential
LD50 Values: Oral (rat): 123 mg/kg; orally toxic at relatively low doses
Ecotoxicity: Significant risk to aquatic environments if large quantities enter waterways; toxic to aquatic invertebrates
Mobility: Not readily biodegradable; persistence expected in environment
Bioaccumulation: Moderate potential for bioaccumulation in aquatic species due to high partition coefficient (logP)
Aquatic Impact: Avoid disposal into surface water, groundwater, or sewer systems
Disposal Methods: Material must be disposed of through approved hazardous chemical incineration in compliance with all federal, state, and local regulations
Contaminated Packaging: Rinse empty containers thoroughly, then label and submit for chemical waste processing
Spill Material: Sweep up dry spills carefully for approved chemical waste disposal to avoid unintentional environmental contamination
UN Number: Not classified as a dangerous good under common regulatory transport frameworks
Packing Group: Not assigned
Transport Hazard Class: Generally not regulated; still recommended to ship in robust, sealed, secondary containment
Special Precautions: Ensure product is protected from moisture, physical damage, and temperature extremes during air, land, or sea shipment
Regulatory Status: Prescription pharmaceutical substance; regulated under national and supranational drug control agencies.
Inventory Listings: Listed on major chemical inventories and health authorities, including US TSCA (as exempted pharmaceutical), EU REACH (medicinal use), and Japan ENCS
Safety Guidance: Follow national occupational exposure limits; users must be trained in chemical hygiene and safe laboratory practice
Label Requirements: GHS-compliant label including hazard pictograms, signal word and safety phrases for user notification
