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Product Name: Cyclohexyl Isocyanate
CAS Number: 3173-53-3
Synonyms: Isocyanatocyclohexane, Cyclohexylisocyanate
Recommended Use: Chemical synthesis, raw material in organic reactions, intermediate for agrochemicals and pharmaceuticals
Supplier: Manufacturer contact details provided on purchase documentation
Emergency Phone Number: Refer to manufacturer safety hotline as stated on product label
GHS Classification: Acute toxicity (inhalation, dermal, oral), skin corrosion/irritation category 2, serious eye damage/irritation category 2A, respiratory or skin sensitization category 1
Signal Word: Danger
Hazard Statements: Harmful if inhaled. Causes skin and eye irritation. May cause respiratory irritation; may cause allergy or asthma symptoms or breathing difficulties if inhaled.
Pictograms: Corrosive, exclamation mark, health hazard
Precautionary Statements: Avoid breathing vapors or mists. Wear protective gloves, eye protection, and face protection. Use only with sufficient ventilation. Wash exposed skin thoroughly after handling. Seek medical attention if you feel unwell.
Chemical Name: Cyclohexyl isocyanate
CAS Number: 3173-53-3
Concentration: 100% pure
Impurities: Minor quantities of related isocyanate compounds may be present
Inhalation: Move victim to fresh air. Support breathing. Seek immediate medical attention if symptoms like wheezing or breathing difficulty appear.
Skin Contact: Remove contaminated clothing. Rinse affected area under running water for several minutes. Use mild soap if available. Contact a physician if irritation or sensitization develops.
Eye Contact: Flush eyes thoroughly with water for at least 15 minutes, lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Get prompt medical evaluation.
Ingestion: Rinse mouth with water. Never give anything by mouth to an unconscious person. Seek immediate medical advice; do not induce vomiting unless instructed by medical personnel.
Symptoms: Irritation, burning sensation, coughing, difficulty breathing, rash, redness, allergic reactions possible in sensitized individuals
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam. Use water spray to cool containers.
Unsuitable Media: Direct water stream may spread fire.
Special Hazards: Incomplete combustion produces toxic gases including nitrogen oxides, carbon monoxide, hydrogen cyanide, and isocyanate vapors.
Protective Equipment: Firefighters use self-contained breathing apparatus (SCBA) and full protective gear.
Firefighting Instructions: Isolate fire scene. Remove personnel to safe locations. Prevent runoff from fire control to enter water supplies or sewer systems.
Personal Precautions: Evacuate unnecessary personnel. Ventilate area. Wear appropriate respiratory protection, chemical-resistant gloves, and protective clothing.
Environmental Precautions: Avoid release to waterways, soil, or groundwater. Notify authorities if product enters environment.
Methods for Cleanup: Absorb spill with inert material like sand, vermiculite. Use spark-proof tools. Place collected material in well-labeled, sealed containers for safe disposal. Clean spill area with suitable neutralizer or detergent solution.
Preventive Actions: Control dust and vapor formation. Use non-sparking equipment during cleanup.
Handling: Work in well-ventilated area with exhaust systems. Avoid inhalation of vapors or direct contact with skin or eyes. Do not eat, drink, or smoke when using this substance.
Storage: Keep container tightly closed in a cool, dry, and well-ventilated facility. Store away from incompatible substances like acids, alcohols, amines, and oxidizers. Avoid environments with excess moisture. Inspect storage containers regularly for leaks or deterioration.
Other Precautions: Keep away from food, beverages, and animal feed. Only trained personnel should handle cyclohexyl isocyanate.
Occupational Exposure Limits (OELs): No specific limit established for cyclohexyl isocyanate; analogous data from related isocyanates suggest low permissible levels.
Engineering Controls: Use chemical fume hoods, local exhaust ventilation, and explosion-proof equipment.
Personal Protective Equipment (PPE):
- Respiratory protection: NIOSH/APR approved respirator for organic vapors and isocyanates
- Skin protection: Chemical-resistant gloves (nitrile, neoprene), full body covering, lab apron
- Eye/face protection: Safety goggles and face shield
- Hygiene measures: Wash hands and exposed skin after handling. Remove contaminated clothing before entering break areas.
Appearance: Clear, colorless to pale yellow liquid
Odor: Pungent, strong isocyanate odor
Odor Threshold: Not established
pH: Not applicable (reacts with water)
Melting Point: -51°C
Boiling Point: 168–170°C
Flash Point: 54°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Explosive Limits: Lower value not established; caution due to flammability
Vapor Pressure: Approx. 2.0 mmHg at 20°C
Vapor Density: 5.5 (air = 1)
Relative Density: 1.01 g/cm³ at 20°C
Solubility: Reacts with water, soluble in organic solvents
Partition Coefficient (log Kow): Not available
Auto-ignition Temperature: Approx. 485°C
Decomposition Temperature: Not determined
Viscosity: Not determined
Chemical Stability: Stable under recommended storage conditions without exposure to moisture or heat
Reactivity: Rapidly reacts with water, alcohols, amines, acids, and strong bases. Releases carbon dioxide and heat during hydrolysis.
Hazardous Reactions: Heat buildup and pressure may occur in closed containers from reaction with moisture.
Hazardous Decomposition Products: Cyanates, nitrogen oxides, carbon monoxide, carbon dioxide
Incompatible Materials: Water, protic solvents, amines, strong acids or bases, oxidizing agents
Acute Toxicity: Harmful by inhalation, skin contact, and ingestion; causes irritation, potential central nervous system effects at high concentrations
Chronic Effects: Prolonged or repeated exposure may cause dermatitis, sensitization, respiratory issues including asthma-like symptoms
Routes of Exposure: Inhalation, skin absorption, eye contact, ingestion
Symptoms: Eye and skin irritation, allergic skin and respiratory reactions, cough, labored breathing, headache, nausea
LD50/LC50 Values: Oral LD50 (rat) 1010 mg/kg (literature value for isocyanates; direct value may vary)
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity and Teratogenicity: No conclusive human data; animal data limited
Other Effects: Sensitized individuals can develop severe allergic reactions on re-exposure
Ecotoxicity: Toxic to aquatic life due to reactivity and bioaccumulation potential; hydrolyzes rapidly in water, so main concern is acute toxicity from initial spill
Persistence and Degradability: Breaks down in water to form amines and carbon dioxide but initial breakdown products can harm aquatic organisms
Bioaccumulative Potential: Limited data; expected to be low due to reactivity, but caution warranted
Mobility in Soil: Tends to bind with soil particles but can migrate with water due to hydrolysis
Other Hazards: Spills pose greater environmental risk before complete hydrolysis
Waste Handling: Dispose as hazardous chemical waste. Do not allow product or contaminated materials to enter drains, sewers, or watercourses.
Methods of Disposal: Incineration in approved facility recommended. Treat residues and residues on equipment by neutralization or controlled chemical decomposition.
Container Disposal: Triple rinse containers before disposal. Puncture and dispose of in accordance with local, national, and federal regulations.
Precautions: Follow all chemical hygiene plans and institutional guidelines. Consult with licensed hazardous waste disposal company.
UN Number: UN 2282
Proper Shipping Name: Isocyanates, toxic, n.o.s. (Cyclohexyl isocyanate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labels: Toxic, hazardous to environment
Special Precautions: Secure tightly. Avoid rough handling or exposure to moisture in transit. Emergency response instructions must accompany shipment.
Regulatory Agencies: Comply with IATA, IMDG, DOT requirements for land, air, and sea transport.
US OSHA: Covered by Hazard Communication Standard (HCS). Mandates label and SDS requirements.
TSCA: Listed on TSCA Inventory.
SARA Title III: Subject to reporting under sections 311/312 for acute health hazards.
EU REACH: Registered. REACH regulations apply for handling, storage, transport, disposal.
Other Regulations: Check local and national regulations for workplace exposure monitoring and environmental release reporting. Labeling must meet GHS/CLP criteria in EU and Globally Harmonized Standard requirements elsewhere.
