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Product Name: Creatinine
CAS Number: 60-27-5
Molecular Formula: C4H7N3O
Molecular Weight: 113.12 g/mol
SYNONYMS: 2-Amino-1-methyl-5H-imidazol-4-one
Product Use: Laboratory reagent, diagnostic marker in medical analysis, chemical synthesis
Manufacturer: Listed contact details from supplier or distributor must be referenced for emergencies
Emergency Telephone Number: Refer to supplier’s emergency contact for specific regional response
Address: Specified by supplier, usually printed on label or packaging
GHS Classification: Not classified as hazardous under the Globally Harmonized System
Signal Word: None
Hazard Statements: Dust may cause mild irritation to eyes, respiratory tract, or skin on repeated exposure
Precautionary Statements: Use with standard laboratory precautions; avoid direct inhalation or contact
Potential Health Effects: Minimal acute toxicity expected under normal use; individuals with respiratory sensitivities should avoid dust
Symbol: Not applicable
Other Hazards: Environmental impact not expected at laboratory scale; large leaks or spills present minimal hazard but may cause localized increase in nitrogen levels in water bodies
Chemical Name: Creatinine
Concentration: 100% pure, no additives under typical reagent-grade product
Impurities: Traces of moisture or residual process solvents might be present at levels not significant for normal use; consult specific supplier’s certificate of analysis for minute contaminants
Other Components: Does not contain other ingredients that contribute to chemical hazard classification at levels above threshold reporting limits
EC Number: 200-466-5
Eye Contact: Immediately flush eyes with gently flowing water for at least 15 minutes; remove contact lenses if present and easy to do; seek medical attention if irritation persists
Skin Contact: Wash affected area thoroughly with soap and water; remove contaminated clothing; seek medical advice if redness or discomfort develops
Inhalation: Move person to fresh air; ensure breathing remains unrestricted; obtain medical assistance if respiratory symptoms such as coughing or difficulty breathing occur
Ingestion: Rinse mouth with water; drink water to dilute; call poison control or seek medical attention if symptoms develop
Personal Protection for Responders: Lab coat, gloves, and safety glasses recommended for all responders
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or CO2 for surrounding fire; product itself does not support combustion
Specific Hazards Arising from Chemical: Decomposition may produce nitrogen oxides and carbon oxides; avoid smoke inhalation
Protective Equipment for Firefighters: Wear self-contained breathing apparatus (SCBA) and full protective clothing during significant fire events
Special Precautions: Cool containers with water spray; prevent runoff from entering drains or watercourses
Personal Precautions: Avoid breathing dust; wear improper protective gloves and eye protection
Environmental Precautions: Prevent discharge to sewers and waterways; sweep up or vacuum to prevent airborne dispersal
Methods for Clean-up: Spilled material should be swept or shoveled into containers for disposal; wipe area with damp cloth to reduce dust residue
Disposal: Dispose in accordance with local, regional, and national regulations
Safe Handling Practices: Use in well-ventilated area; minimize dust generation; avoid ingestion and unnecessary contact
Storage Conditions: Store at room temperature or as advised by supplier, away from moisture and incompatible substances
Incompatible Materials: Strong oxidizers, acids, and bases should be avoided
Special Storage Instructions: Keep container tightly closed, labeled, and in a secure area; prevent product from absorbing moisture from the air
Engineering Controls: Work in fume hood or use local exhaust ventilation to keep airborne particulates below recommended limits
Personal Protective Equipment (PPE): Laboratory gloves, chemical-resistant safety goggles, clean laboratory coats; for sensitive persons, a dust mask or particulate respirator adds protection
Occupational Exposure Limits: No established permissible exposure limit by OSHA, ACGIH, or NIOSH
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke in areas where material is handled
Physical State: Solid, crystalline powder
Color: White to off-white
Odor: Odorless
Melting Point: 300°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at ambient temperatures
Solubility: Soluble in water, practically insoluble in most organic solvents
pH (1% solution in water): Approximately 6.5-7.5
Partition Coefficient (Log Kow): Not determined
Other Data: Decomposition releases fumes of nitrogen-containing compounds; material is stable under dry, normal laboratory conditions
Chemical Stability: Stable in dry conditions and at recommended storage temperature
Conditions to Avoid: Moisture, exposure to strong acids or bases, strong oxidizing agents, extreme heat
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide formed at high temperatures
Reactivity: Not expected to polymerize or undergo dangerous reactions under normal laboratory use
Acute Toxicity: Data indicate low toxicity for mammals; LD50 values not established for pure creatinine, but studies report low single-dose hazard
Routes of Exposure: Inhalation, skin, and eye contact, ingestion
Symptoms of Exposure: Dust may cause mild irritation to eyes, skin, or respiratory tract
Sensitization: No known reports of allergy or sensitization
Chronic Exposure: Not classified as a carcinogen, mutagen, or reproductive toxin by IARC, NTP, or OSHA
Other Effects: Creatinine is a normal biological marker, but high concentrations may reflect underlying medical issues in mammals, not chemical poisoning
Toxicity to Aquatic Life: Not expected to be hazardous in the environment at standard laboratory levels; little to no evidence of toxicity to aquatic organisms
Persistence and Degradability: Readily biodegradable through typical environmental processes
Bioaccumulation: Not likely to bioaccumulate
Mobility in Soil/Water: High water solubility may allow moderate mobility in water; breakdown products are natural nitrogen cycle components
Additional Notes: Bulk spills into natural waters might contribute excess nitrogen, encouraging algal growth
Disposal Methods: Place waste material in a sealed container; handle through an approved chemical waste disposal contractor
Contaminated Packaging: Rinse empty containers and dispose of them as laboratory chemical waste
Relevant Regulations: Country-specific hazardous waste regulations control disposal; never release into environment
Precautions: Wear disposable gloves and eye protection during clean-up; ensure waste does not mix with incompatible substances
UN Number: Not regulated for transport
Transport Hazard Class: Not classified as dangerous for road (ADR/RID), air (ICAO/IATA), or sea (IMDG) shipment
Packing Group: Not applicable
Environmental Hazards: Not considered a marine pollutant
Special Precautions: Transport in original packaging with proper labeling and secure lid to prevent accidental release
US TSCA: Listed on Toxic Substances Control Act inventory
EU REACH: Exempt as a naturally occurring substance; not classified as a substance of very high concern
WHMIS Classification: Not controlled in Canada
OSHA Hazardous Chemical: Not regarded as hazardous according to OSHA regulations for laboratory chemicals
Other Regulatory References: No SARA Title III hazards, not listed as a California Proposition 65 chemical, not subject to international restrictions
Labeling Requirements: Standard laboratory precautionary labeling; includes product name, manufacturer contact, recommended handling procedures
