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Product Name: Clonidine Hydrochloride
Chemical Name: 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride
CAS Number: 4205-90-7
Molecular Formula: C9H9Cl2N3 • HCl
Recommended Use: Pharmaceutical ingredient, research chemical
Manufacturer: [Insert appropriate manufacturer details]
Contact Number: [Insert emergency contact number]
Hazard Classification: Harmful if swallowed, causes serious eye irritation, may cause respiratory irritation
Signal Word: Warning
Hazard Statements: Toxic to organs if ingested, may depress central nervous system, possible skin absorption
Precautionary Statements: Avoid breathing dust, wear proper protective apparel, wash hands thoroughly after handling
Substance: Clonidine Hydrochloride
Concentration: >98%
Impurities: Less than 1% total impurities (individual impurities less than 0.2%)
Other Ingredients: No other active component, manufacturing residues traceable
Eye Contact: Rinse carefully with plenty of water for at least 15 minutes, seek medical advice promptly
Skin Contact: Remove contaminated clothing, wash skin well with soap and water, get attention for persistent symptoms
Inhalation: Move person to fresh air, monitor breathing, get emergency assistance for trouble breathing or dizziness
Ingestion: Rinse mouth, do not induce vomiting, consult poison control for further instruction, get medical aid quickly
Note to Physician: Monitor blood pressure and CNS symptoms, provide care as needed for hypotension or bradycardia
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Specific Hazards: May produce toxic fumes or hydrochloric acid gas under fire, possible release of nitrogen oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus and protective suit advised, avoid exposure to dust and vapors
Fire-Fighting Procedures: Move containers from fire area, keep upwind, use regular firefighting measures while aware of possible toxic gas generation
Personal Precautions: Wear gloves, eye protection, face shield, dust mask or respirator
Environmental Precautions: Prevent spillage from entering sewers or water bodies, clean up immediately to avoid spread
Cleanup Methods: Collect spilled material using non-sparking tools, wipe surfaces with wet towels, dispose of in a sealed container per local regulations
Notification: Inform proper authorities if environmental contamination risk is present
Handling: Store in tightly sealed container, open packages only in well-ventilated area, use mechanical extraction if handling bulk amounts, minimize dust generation
Storage: Store at 15-30°C in a dry, ventilated, dark location, away from incompatible substances (oxidizing agents, strong acids or bases), avoid exposure to moisture and sunlight, proper signage on storage location for chemical hazards
Engineering Controls: Work under chemical fume hood, local exhaust ventilation advised
Personal Protective Equipment: Latex or nitrile gloves, chemical safety goggles, long-sleeved chemical-resistant clothing
Respiratory Protection: NIOSH-approved respirator if dust or aerosols likely
Hygiene Measures: Wash hands and exposed areas before meals and at shift end, don’t eat, drink, or smoke while handling
Exposure Limits: No established ACGIH or OSHA occupational exposure limit for clonidine hydrochloride
Appearance: White or off-white crystalline powder
Odor: Odorless
Molecular Weight: 266.56 g/mol
pH (1% solution): 4.0 - 5.5
Melting Point: 305-310°C (decomposes)
Solubility: Freely soluble in water, soluble in methanol and ethanol
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Negligible at room temperature
Density: Approx. 1.45 g/cm³
Partition Coefficient: Log Pow -1.6
Flash Point: Not relevant for solid
Autoignition Temperature: Not available
Chemical Stability: Stable under normal storage and handling
Thermal Decomposition: May give off toxic fumes including HCl and nitrogen oxides
Conditions to Avoid: Excessive heat, exposure to light or moisture, static discharge
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Polymerization: No hazardous polymerization expected
Acute Toxicity: Estimated oral LD50 (rat) ranges from 100-200 mg/kg, toxic if ingested
Chronic Toxicity: Potential for CNS depression, hypotension, bradycardia on repeated exposure
Routes of Exposure: Ingestion, inhalation, dermal, ocular
Symptoms: Drowsiness, bradycardia, dry mouth, headache, hypotension, in severe cases - collapse or coma
Carcinogenicity: No classification by IARC, NTP, or OSHA
Mutagenicity: Studies show not mutagenic in standard assays
Reproductive Effects: At high doses, effects on offspring in animal studies, not observed in standard therapeutic use
Ecotoxicity: Data limited, low aquatic toxicity expected at environmental concentrations
Persistence and Degradability: Not readily biodegradable, breaks down slowly under standard conditions
Bioaccumulative Potential: Low, log Pow -1.6 limits accumulation in organisms
Mobility in Soil: Moves through soil slowly, binds moderately to organic matter
Other Impacts: No known significant effects on birds, bees, or plants at low residual concentrations
Product Disposal: Treat as hazardous pharmaceutical waste, incinerate in licensed facility where possible, dilute solutions poured to drain only with authority approval and after neutralization
Container Disposal: Triple rinse, destroy, dispose via certified waste contractor
Regulatory Disposal: Follow local, regional, and national regulations for hazardous chemical disposal, documentation required for off-site destruction
UN Number: Not classified as dangerous for transport
UN Shipping Name: Not regulated
Transport Hazard Class: None under UN regulations
Packing Group: No specific packing group
Special Precautions: Ensure containers are sealed, prevent container breakage during loading and movement, keep away from food and feed during transit
Safety, Health and Environmental Regulations/Legislation: Subject to regulation as a pharmaceutical in most jurisdictions, not classified under major chemical regulations such as TSCA or REACH for industrial use
Label Requirements: Required labeling under OSHA Hazard Communication Standard (29 CFR 1910.1200), with appropriate pictograms and signal words
Inventory Status: Listed under pharmaceutical and health product inventories
GHS Classification: Acute toxicity (Oral) Category 4, Eye irritation Category 2A, Specific target organ toxicity-repeated exposure Category 2
Other Regulatory Info: Check with local agencies for reporting and handling of pharmaceutical active substances, special handling for disposal as controlled medical waste may apply
