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Product Name: Clobetasol Propionate
Synonyms: 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate
Recommended Use: Topical corticosteroid for dermatological use
Chemical Family: Corticosteroid
Molecular Formula: C25H32ClFO5
Molecular Weight: 466.97 g/mol
Manufacturer: Refer to product packaging or purchasing distributor for manufacturer and emergency contact information
CAS Number: 25122-46-7
Emergency Phone Number: Listed on supplier’s product label
Preparation/Revision Date: See current batch documentation
Emergency Overview: Off-white powder with no strong odor, not combustible as supplied but forms irritating and hazardous fumes if involved in fire
Classification: Not classified as hazardous under GHS, can produce adverse health effects on prolonged or repeated contact
Routes of Exposure: Eyes, skin, inhalation, ingestion
Potential Health Effects: Skin irritation, eye irritation; long-term or high-dose exposure may cause systemic corticosteroid effects such as suppression of the hypothalamic-pituitary-adrenal axis; may affect immune system over long exposure
Label Elements: Not for general consumer use except as directed by healthcare provider; avoid unnecessary skin and eye contact
Signal Word: Warning for occupational settings
Precautionary Statements: Avoid inhalation of dust, avoid contact with skin and eyes, use only with appropriate personal protection
Other Hazards: Not considered a flammable solid; as with most dusts, risk of dust explosion in very high concentrations and confined spaces
Ingredient: Clobetasol Propionate
Concentration: 98-100% (pharmaceutical grade)
Impurities: Trace amounts of related corticosteroid synthesis byproducts
Other Components: No intentionally added excipients in raw drug substance
CAS Registry Number: 25122-46-7
Inhalation: Move person to fresh air, seek medical attention if symptoms such as coughing, shortness of breath, or throat irritation develop
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, seek medical advice if redness, irritation, or sensitivity persist
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; lift eyelids occasionally; consult a healthcare professional if irritation continues
Ingestion: Rinse mouth with water; do not induce vomiting unless advised by medical personnel; seek immediate medical attention
Most Important Symptoms and Effects: Skin irritation, allergic reactions, steroid effects after significant or repeated exposure
Advice to Medical Personnel: Treat symptomatically; systemic absorption can cause adrenal suppression and immunosuppression in chronic occupational cases
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide (CO2)
Unsuitable Media: Strong water jets may spread contaminated material
Specific Hazards: May produce hazardous fumes such as hydrogen chloride, carbon oxides, and fluorinated organics
Firefighter Protection: Wear self-contained breathing apparatus and full protective gear; avoid inhaling combustion gases
Explosion Data: Clobetasol propionate dust rarely forms explosive mixtures with air; avoid generating dust clouds
Special Procedures: Cool containers with water if exposed to heat or flames; do not allow runoff from fire control to enter waterways
Personal Precautions: Minimize dust generation, provide adequate ventilation, wear protective gloves and eye protection
Environmental Precautions: Prevent entry to drains, surface waters, or soil; notify responsible authorities if spill contaminates environment
Cleanup Methods: Collect spilled material carefully using non-sparking hand tools and place in suitable labeled container; clean spill area with damp cloths, avoid dry sweeping; decontaminate area using soap and water
Decontamination: Dispose of cleanup materials and PPE as hazardous waste
Handling Precautions: Avoid breathing dust, avoid skin and eye contact, use local exhaust/ventilation during bulk handling
Hygiene Practices: Wash hands and exposed skin before eating, drinking, smoking, or leaving work area
Safe Storage Requirements: Store in tightly closed, light-resistant containers at room temperature (15–30°C); keep in dry, well-ventilated area, separate from incompatible substances (oxidizers, acids)
Specific Storage Conditions: Maintain in original labeled containers; protect from excessive moisture and direct sunlight; restrict access to authorized personnel
Engineering Controls: Use process enclosures and local exhaust ventilation to minimize airborne dust; maintain atmospheric levels below occupational exposure limits where established
Eye Protection: Chemical safety goggles
Hand Protection: Disposable nitrile gloves or similar chemical-resistant types
Skin and Body Protection: Wear protective lab coat or coveralls and closed-toed shoes
Respiratory Protection: Use approved NIOSH/OSHA respirators for dust if airborne concentrations may exceed limits or if ventilation is inadequate
Hygiene Measures: Change contaminated clothing promptly, avoid hand-to-mouth contact, wash after handling
Appearance: White to off-white crystalline powder
Odor: Odorless or faint medicinal
Melting Point: 196–200°C
Boiling Point: Not available
Vapor Pressure: Negligible at room temperature
Solubility: Practically insoluble in water; freely soluble in acetone, chloroform; sparingly soluble in alcohol
pH: Not applicable
Density: No data
Partition Coefficient (log Kow): Estimated >3 (lipophilic)
Evaporation Rate: Not applicable
Flash Point: Not applicable for solid
Flammability: Will burn under fire conditions
Autoignition Temperature: Not established
Chemical Stability: Stable under normal conditions for storage and use
Conditions to Avoid: Strong sunlight, moisture, extremes of temperature, sources of ignition
Materials to Avoid: Strong oxidizing agents, strong acids and bases, reactive metals
Hazardous Decomposition Products: May give off hydrogen chloride, carbon oxides, chlorine compounds, fluorinated organics on combustion or thermal breakdown
Polymerization: Will not occur under recommended handling conditions
Acute Toxicity: Oral LD50 in rats: >1000 mg/kg (literature); not acutely toxic, but corticosteroid effects present on repeated exposure
Chronic Toxicity: Prolonged or repeated exposure can cause adrenal suppression, skin thinning, immunosuppression, or systemic steroid effects
Skin/Eye Irritation: Mild to moderate irritant to skin and eyes
Sensitization: Can cause sensitization or allergic reactions in susceptible individuals
Mutagenicity/Carcinogenicity: No evidence for carcinogenic potential in animal studies; not classified as mutagenic or carcinogenic by IARC or NTP
Reproductive Effects: High doses may interfere with fetal development or fertility, based on corticosteroid class effects; use only as prescribed in pregnancy
Other Data: Not anticipated to pose significant health hazard when handled with appropriate safety precautions
Ecotoxicity: Toxic to aquatic life at high concentrations; may disrupt aquatic organism endocrine systems
Persistence and Degradability: Not rapidly biodegradable in soil or water; may persist and bioaccumulate
Bioaccumulation Potential: Lipophilic, with tendency to bioaccumulate (estimated log Kow >3)
Mobility in Soil: Likely to bind to organic matter and sediments, low water solubility, reduced mobility
Other Adverse Effects: Dispose carefully; avoid release to the environment, especially near water sources
Waste Treatment Methods: Dispose of as hazardous pharmaceutical waste per local, regional, and national regulations
Incineration: Suitable for high-temperature incineration by licensed contractor; do not dispose with regular trash
Contaminated Packaging: Triple rinse containers before disposal; handle rinsate as hazardous, puncture and dispose of via hazardous waste program
Precautions: Do not allow material to reach drains, surface or groundwater; prevent environmental release during disposal process
UN Number: Not regulated for transport in small quantities
UN Proper Shipping Name: Pharmaceutical intermediate or steroid, not otherwise specified
Transport Hazard Class: Not classed as hazardous for bulk transport by DOT, IATA, IMDG
Packing Group: Not assigned
Special Precautions: Package securely to prevent damage and dust release, accompany with SDS and transport documentation for shipments
US OSHA Status: Not specifically regulated as hazardous but handle with protection for potential pharmaceutical risks
TSCA Inventory: Not listed (pharmaceutical active ingredient)
SARA Title III: Not subject to SARA Section 313 reporting (not an extremely hazardous substance)
California Proposition 65: Not listed
WHMIS (Canada): Controlled product, classification based on health hazard criteria, not for general consumer sale
REACH (EU): Exempt as a medicinal product but requires risk management during manufacture
Other International Regulations: Follows specific national/local rules for use, handling, and pharmaceutical disposal
