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Product Name: Clindamycin Phosphate
Synonyms: Clindamycin hydrogen phosphate; (7S)-7-chloro-6,7,8-trideoxy-6-[ ( methylthio ) acetyloxy ]-1-methyl-4-propyl-1,2,3,4-tetrahydro-2-oxoquinoline phosphate
Chemical Formula: C18H34ClN2O8PS
CAS Number: 24729-96-2
Recommended Use: Antibacterial agent for topical, oral, and injectable medications
Manufacturer: Pharmaceutical production companies globally distribute clindamycin phosphate for clinical and laboratory applications
Emergency Contact: Refer to regional poison control or manufacturer's emergency number printed on packaging
Classification: Toxic if swallowed, irritating to eyes, skin, and respiratory tract
Label Elements: Skull and crossbones symbol, Exclamation mark for irritant
Hazard Statements: May cause allergic skin reactions, serious eye irritation, respiratory inflammation, and acute toxicity on exposure
Precautionary Statements: Use in well-ventilated spaces, wear protective gear when handling, keep away from food and drink
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms: Coughing, shortness of breath, skin rash, nausea, vomiting, abdominal cramps, red or watery eyes
Chemical: Clindamycin Phosphate
Concentration: Usually >98% purity in active pharmaceutical ingredients
Impurities: Trace possible—water, residual solvents, process impurities (each under 1%)
Other Ingredients: None listed for pure technical or pharmaceutical grade, avoid mixing with oxidizing agents
Inhalation: Remove patient to fresh air, monitor breathing, offer oxygen if labored, seek immediate medical care
Skin Contact: Wash exposed skin areas with running water for 15 minutes, remove contaminated clothing, get medical attention
Eye Contact: Rinse eyes with low-pressure water for 15 minutes, lift lids occasionally, seek specialist instruction from poison control or physician
Ingestion: Do not induce vomiting, rinse mouth, give 1-2 cups of water if conscious, quick transport to emergency service
Most Important Symptoms: Allergic rash, tightness in chest, difficulty breathing, gastrointestinal upset
Immediate Medical Attention: Required for inhalation, large exposures, or severe reactions
Suitable Extinguishing Media: CO2, dry chemical, alcohol-resistant foam, water spray
Specific Hazards: Emits toxic fumes of chlorine, nitrogen oxides, sulfur oxides, and phosphorus oxides on combustion
Protective Equipment: Wear full-body fire-resistant suit, self-contained breathing apparatus, eye protection
Special Precautions: Avoid inhaling combustion gases, shut off fuel source if possible without risk
Personal Precautions: Evacuate area, provide adequate ventilation, use personal protective gloves, goggles, respirators
Environmental Precautions: Block entry to waterways, sewers, soil, and drains—use absorbent materials
Cleanup Methods: Sweep up spilled material, avoid dust generation, place in sealed containers labeled for hazardous chemical disposal
Decontamination: Rinse area with detergent and water, ventilate until dry
Disposal: Follow local and federal hazardous material rules for discarding all contaminated items
Handling: Use with personal protective equipment, avoid dust, do not eat/drink/smoke during handling, store in tightly sealed containers
Storage Conditions: Store out of sunlight, in cool, well-ventilated area, away from heat, oxidizers, acids
Specific Storage: Dedicated chemical cabinets or segregated pharmaceutical storage zones recommended
Incompatibility: Strong oxidizing agents, mineral acids, moisture
Exposure Limits: No established OSHA PEL or ACGIH TLV for clindamycin phosphate; general workplace dust limits may apply
Engineering Controls: Use fume hood, local exhaust, and keep workplace well-ventilated
Respiratory Protection: NIOSH-approved respirators for powder forms or large scale use
Eye Protection: Tightly fitting chemical splash goggles
Skin Protection: Chemical-resistant gloves, lab coat or disposable gown, closed shoes
Hygiene Measures: Thorough handwash after handling, separate storage for protective clothing, no open skin
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: 3.0 to 5.5 (1% solution in water)
Melting Point: Decomposes above 180°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Freely soluble in water, sparingly in alcohol, insoluble in chloroform or ether
Density: Approximately 1.4 g/cm³
Vapor Pressure: Not significant at room temperature
Partition Coefficient (n-octanol/water): LogP -3.5 to -4.5
Other Data: Stable under recommended storage conditions; sensitive to light and moisture
Chemical Stability: Stable at room temperature in tightly closed containers
Reactivity: Reacts with strong oxidizers, acids, may decompose under high heat or exposure to UV light
Decomposition Products: Hazardous gases including chlorine, phosphorus oxides, sulfur compounds, and nitrogen oxides
Polymerization: Not expected to occur
Acute Toxicity: Oral LD50 (rat): >4,000 mg/kg; skin absorption LD50 (rat): >2,000 mg/kg
Chronic Toxicity: Long-term exposure linked with gastrointestinal symptoms, possible liver/kidney changes or blood abnormalities
Sensitization: May cause allergic skin reactions in predisposed individuals
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Mutagenicity: Negative in standard bacterial mutation and mammalian cell assays
Other Information: Prolonged or repeated skin contact may aggravate existing dermatitis, inhalation may impact respiratory tract
Ecotoxicity: Potentially toxic to aquatic organisms at high concentrations, may affect microorganisms
Persistence and Degradability: Moderately biodegradable under aerobic conditions
Bioaccumulation Potential: Low, based on logP and structure
Mobility in Soil: Fairly mobile in water, limited adsorption to soils due to solubility
Other Adverse Effects: Improper disposal could disrupt wastewater and natural bacterial ecosystems
Waste Treatment Methods: Incinerate in licensed facility or treat as hazardous chemical waste
Container Disposal: Empty containers should be triple-rinsed then rendered unusable
Local Disposal Rules: Comply with all national, regional, and local hazardous waste regulations
Special Cautions: Avoid release into the environment, consult with waste management authorities for best disposal practices
UN Number: Unregulated under most international transport standards as a non-bulk pharmaceutical (check for large-scale or concentrated shipment requirements)
Proper Shipping Name: Clindamycin Phosphate
Transport Hazard Class: Not classified as hazardous for the purpose of DOT, IATA, IMDG
Packaging Instructions: Use sealed primary and secondary containment, keep away from food, feed, oxidants
Environmental Hazards: Careful packaging to prevent dust generation or accidental release during transit
Safety, Health and Environmental Regulations: Regulated as an API (active pharmaceutical ingredient) under FDA and EMA guidelines
Inventory Status: Listed in TSCA (US), EINECS/ELINCS (Europe), DSL (Canada), AICS (Australia)
OSHA Hazards: Target organ effect, Toxic by ingestion, Irritant
Other Regulations: Subject to workplace chemical safety laws, transport codes, waste disposal protocols, environmental protection standards, and national pharmaceutical rules
Label Requirements: Hazard warnings, manufacturer identity, substance name, precautionary measures specified for all containers and workplaces storing the compound
